|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence.
|
21226922 |
2011 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
In a BSL3+ laboratory, viruses were generated that possessed either the 1918 NS1 gene alone or the entire 1918 NS segment in a background of influenza A/WSN/33 (H1N1), a mouse-adapted virus derived from a human influenza strain first isolated in 1933.
|
11226311 |
2001 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.
|
19726611 |
2009 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Characterization of a novel mutation in NS1 protein of influenza A virus induced by a chemical substance for the attenuation of pathogenicity.
|
25793397 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Routine surveillance specimens obtained from 70 patients with pH1N1 infection were evaluated for mutations associated with increased virulence (PB1-F2, PB2 and NS1 genes) or antiviral resistance (neuraminidase gene, NA) using MSCSA and Sanger sequencing.
|
24699508 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30.
|
23886034 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Strains of the 2009 H1N1 pandemic influenza A virus could be divided into two categories based on the V123I mutation in the NS1 gene: G1 (characterized as 123 Val) and G2 (characterized as 123 Ile).
|
23418535 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.
|
20809948 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Previously we have developed a prototype for conditionally replicating oncolytic influenza A virus which is based on deletions in the non-structural (NS1) protein.
|
20647775 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
|
21918006 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Since viruses are known to induce memory T cells, an attenuated influenza A/PR8/34 virus with a truncated nonstructural (NS1) gene was generated containing the HER-2 CTL E75 epitope in its neuraminidase protein (KIF-NS virus).
|
15868901 |
2005 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
This review focuses on the influenza A virus NS1 protein and outlines current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.
|
31154753 |
2019 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
A naturally truncated NS1 protein of influenza A virus impairs its interferon-antagonizing activity and thereby confers attenuation in vitro.
|
27400993 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
|
23209422 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
It is known that the influenza A virus NS1 protein (NS1-A) interacts with RIG-I and TRIM25 to suppress the activation of RIG-I-mediated signaling.
|
27122586 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Since hemagglutinin (HA) and non-structural 1 (NS1) proteins are relevant in respect of adaptive and innate immune responses, the present study was aimed at establishing the intra-host genetic heterogeneity of HA and NS1 genes, applying ultra-deep pyrosequencing (UDPS) to nasopharyngeal swabs (NPS) from patients with confirmed influenza A(H1N1)pdm09 infection.
|
27186639 |
2016 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells.
|
22866982 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Our results showed that non-conservative mutations slightly stabilized or destabilized structural domains of NS1 or NS1-dsRNA complex, hence slightly increased or decreased the function of NS1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus.
|
20970747 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.
|
20686040 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Here, we demonstrate that UAP56 also co-localizes with the influenza A viral NS1 protein, which counteracts host cell innate immune responses stimulated by virus infection.
|
30258431 |
2018 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Pathogenicity and host range are determined to a large extent by the polymerase, the haemagglutinin and the NS1 protein of influenza A viruses.
|
21319184 |
2011 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
These influenza A viruses encode mCherry fused to the viral non-structural 1 (NS1) protein and display comparable growth kinetics to wild-type viruses in vitro.
|
25553516 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Our data further suggest that NS1 also posttranscriptionally alters RIG-I pre-mRNA processing by binding to the RIG-I pre-mRNA.<b>IMPORTANCE</b> A key virulence factor of influenza A virus is the NS1 protein, which inhibits various cellular processes to facilitate viral gene expression.
|
30258002 |
2018 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The multifunctional NS1 protein of influenza A viruses.
|
18796704 |
2008 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/ strains may be a common event during co-infection.
|
22744180 |
2012 |