|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The fact that influenza A and influenza B virus NS1 proteins bind to NS1-I suggests that this cellular protein plays a role in the influenza virus life cycle.
|
8764047 |
1996 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
In a BSL3+ laboratory, viruses were generated that possessed either the 1918 NS1 gene alone or the entire 1918 NS segment in a background of influenza A/WSN/33 (H1N1), a mouse-adapted virus derived from a human influenza strain first isolated in 1933.
|
11226311 |
2001 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells.
|
11719449 |
2001 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Taken together, these data indicate that the IFN antagonistic NS1 protein of influenza A viruses has IFN-dependent antiapoptotic potential.
|
11799156 |
2002 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
AlteredExpression |
BEFREE |
Most significantly, a virus containing the 1918 pandemic NS1 gene was more efficient at blocking the expression of IFN-regulated genes than its parental influenza A/WSN/33 virus.
|
12149435 |
2002 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Since viruses are known to induce memory T cells, an attenuated influenza A/PR8/34 virus with a truncated nonstructural (NS1) gene was generated containing the HER-2 CTL E75 epitope in its neuraminidase protein (KIF-NS virus).
|
15868901 |
2005 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
As deletion of the complete NS1 gene has to date been reported only in the human H1N1 strain A/PR/8/34, it remained unclear whether NS1 is a non-essential virulence factor in other influenza A virus strains as well.
|
17412966 |
2007 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
|
17053203 |
2007 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The multifunctional NS1 protein of influenza A viruses.
|
18796704 |
2008 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.
|
19726611 |
2009 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
|
19454348 |
2009 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Our results showed that non-conservative mutations slightly stabilized or destabilized structural domains of NS1 or NS1-dsRNA complex, hence slightly increased or decreased the function of NS1 protein and consequently enhanced or reduced the pathogenicity of the H1N1 virus.
|
20970747 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.
|
20686040 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway can support the replication of influenza A virus through binding of viral NS1 protein to the Src homology 3 (SH3) domain of p85beta regulatory subunit of PI3K.
|
20653952 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence.
|
20410267 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.
|
20444891 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.
|
20809948 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Previously we have developed a prototype for conditionally replicating oncolytic influenza A virus which is based on deletions in the non-structural (NS1) protein.
|
20647775 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence.
|
21226922 |
2011 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Pathogenicity and host range are determined to a large extent by the polymerase, the haemagglutinin and the NS1 protein of influenza A viruses.
|
21319184 |
2011 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
|
21918006 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
|
23209422 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
We propose that NS1 protein of both H5N1 and H11N1 subtypes of influenza viruses are capable of influencing host immune responses and possess necessary functionality to support apoptosis in host cells.
|
22866982 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
This indicates that the heterologous interactions between NS1 proteins from different influenza A virus subtypes/ strains may be a common event during co-infection.
|
22744180 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
The role of the NS1 protein in modulating influenza A virulence and host range was assessed by adapting A/Hong Kong/1/1968 (H3N2) (HK-wt) to increased virulence in the mouse.
|
22363747 |
2012 |