|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
|
19454348 |
2009 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence.
|
21226922 |
2011 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus NS1 protein has multiple functions in the infected cell during the virus life cycle.
|
22171255 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30.
|
23886034 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A viruses circulating in humans from ∼1950 to ∼1987 featured a nonstructural (NS1) protein with a C-terminal extension of seven amino acids.
|
23926347 |
2013 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus genomic segments eight codes for non-structural 1 (NS1) protein that is involved in evasion of innate antiviral response, and nuclear export protein (NEP) that participates in the export of viral ribonucleoprotein (RNP) complexes, transcription and replication.
|
24657783 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response.
|
27914808 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked.
|
28076660 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Influenza A virus non-structural-1A binding protein (named as Ns1abp) was originally identified as a host protein from human that bound to the viral NS-1 protein.
|
29510164 |
2018 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
|
17053203 |
2007 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
NS1 proteins of influenza A and B viruses share limited sequence homology, yet both are potent manipulators of host cell processes, particularly interferon (IFN) induction.
|
28869005 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus.
|
31754723 |
2020 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
A naturally truncated NS1 protein of influenza A virus impairs its interferon-antagonizing activity and thereby confers attenuation in vitro.
|
27400993 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Allele B NS1 proteins from corresponding subtypes of influenza A viruses are weak in this inhibition, despite significant levels of expression of each NS1 protein in human A549 cells.
|
22239235 |
2012 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
As a consequence, influenza NS1 gene knockout virus delNS1 (an influenza A virus lacking the NS1 open reading frame) fails to replicate in normal cells but produces infectious particles in PKR-deficient cells.
|
11719449 |
2001 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
As deletion of the complete NS1 gene has to date been reported only in the human H1N1 strain A/PR/8/34, it remained unclear whether NS1 is a non-essential virulence factor in other influenza A virus strains as well.
|
17412966 |
2007 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Characterization of a novel mutation in NS1 protein of influenza A virus induced by a chemical substance for the attenuation of pathogenicity.
|
25793397 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Conclusively, subtype-specific sequence variations in the IAV NS1 protein result in subtype-specific differences in JNK signaling upon IAV infection.
|
24872593 |
2014 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Functions of the influenza A virus NS1 protein in antiviral defense.
|
25638592 |
2015 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
Genetic divergence of influenza A NS1 gene in pandemic 2009 H1N1 isolates with respect to H1N1 and H3N2 isolates from previous seasonal epidemics.
|
20809948 |
2010 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Here we show that the interaction between NS1 protein of influenza A/Shantou/602/06 (H3N2) and nucleolin, a ubiquitous protein of nucleolus repressed RNA Pol I-dependent transcription via establishing hyper-methylation in the UCE of rRNA gene promoter.
|
29259342 |
2017 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Here, we demonstrate that UAP56 also co-localizes with the influenza A viral NS1 protein, which counteracts host cell innate immune responses stimulated by virus infection.
|
30258431 |
2018 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
Here, we showed that influenza A virus NS1 protein inhibits the formation of autophagosomes.
|
30619194 |
2018 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
GeneticVariation |
BEFREE |
In a BSL3+ laboratory, viruses were generated that possessed either the 1918 NS1 gene alone or the entire 1918 NS segment in a background of influenza A/WSN/33 (H1N1), a mouse-adapted virus derived from a human influenza strain first isolated in 1933.
|
11226311 |
2001 |
|
IVNS1ABP
|
Influenza A
|
0.100 |
Biomarker |
BEFREE |
In addition, intranasal instillation of AAV8-3xIRF-ISRE-Luc showed a rapid and transient IFN-I response in the respiratory tract of mice infected with the influenza A/PR8/34 virus lacking the NS1 protein.
|
27007218 |
2016 |