Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. 15541308

2004

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. 16272257

2005

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance. 16533964

2006

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. 16321986

2006

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. 29125462

2017

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Analysis of LRRK2 functional domains in nondominant Parkinson disease. 16247070

2005

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations. 16157909

2005

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. 30398148

2018

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease. 16298482

2006

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. 18213618

2008

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. 25201882

2014

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT LRRK2 gene in Parkinson disease: mutation analysis and case control association study. 16157901

2005

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. 29127255

2018

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD. 16102999

2005

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. 26824392

2016

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation. 15929036

2005

Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder)
0.930 GeneticVariation UNIPROT Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. 15726496

2005