×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
22885922
2012
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
The aim of this study was to investigate association of WFS1 genes polymorphisms (rs734312 and rs10010131 ) with T2D by conducting a meta-analysis.
23257691
2013
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Nine variants in FTO rs8050136 , WFS1 rs10010131 , CDKN2A/B rs10811661 , KCNJ11 rs5219 , CDC123/CAMK1D rs12779790 , JAZF1 rs864745 , SLC30A8 rs13266634 , CDKAL1 rs10946398 , and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05).
23298195
2013
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASDB
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
23300278
2013
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
At six loci with genome-wide evidence for T2D association (AP3S2, KCNK16, NOTCH2, SCL30A8, VPS26A, and WFS1 ) predicted mRNA target sites for islet-expressed miRNAs overlapped potentially causal variants.
23372846
2013
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
While FTO rs8050136 and rs17817449 , ADAMTS9 rs4607103 , and WFS1 rs10010131 were initially associated with T2DM , this was lost upon multiple testing correction.
24145053
2013
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASDB
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
24509480
2014
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
24509480
2014
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Differential promoter activity by nucleotide substitution at a type 2 diabetes genome-wide association study signal upstream of the wolframin gene.
25800097
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Although the connection between loss of function mutations of the WFS1 gene and DIDMOAD-syndrome including diabetes mellitus underpins the significance of wolframin in the pathogenesis, exact role of WFS1 polymorphic variants in the development of type 1 and type 2 diabetes has not been discovered yet.
26426397
2015
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Genetic variants of WFS1 , CDKAL1, CDKN2BAS, TCF7L2, HHEX, KCNQ1, TSPAN8/LGR5, FTO, and TCF2 were associated with the risk for T2D with MetS, as well as the risk for development of T2D with at least one of the MetS components (P < 0.05).
26599349
2015
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
GENOMICS_ENGLAND
A three-step programmed method for the identification of causative gene mutations of maturity onset diabetes of the young (MODY).
27185633
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
We examined the effect of interactions between seven incretin-related genetic variants in GIPR, KCNQ1, TCF7L2 and WFS1 and dietary components (whey-containing dairy, cereal fibre, coffee and olive oil) on the risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study.
27623947
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
AlteredExpression
BEFREE
Altered expression of WFS1 and NOTCH2 genes may play a role in pathogenesis and development of DN in patients with T2DM .
29626590
2018
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
29632382
2018
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Identification of a missense variant in the WFS1 gene that causes a mild form of Wolfram syndrome and is associated with risk for type 2 diabetes in Ashkenazi Jewish individuals.
30014265
2018
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
30054458
2018
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
30595370
2019
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
HHEX, HMGA2, GLIS3, MTNR1B and PARK2) and some overlap with SNPs associated with T2D (e.g. rs3821943 near WFS1 and rs508419 near ANK1).
31123324
2019
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
This study revealed an association of SIRT1 and WFS1 with T2D risk.
31759989
2020