|
rs4689388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.820 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs4689388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
BEFREE |
A recent T2D GWAS revealed an association signal (rs4689388) upstream of the gene encoding Wolfram syndrome 1 (WFS1) whose intrinsic nucleotide variants had been previously associated with T2D in several candidate gene analyses.
|
25800097 |
2016 |
|
rs4689388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
BEFREE |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897).
|
23144361 |
2012 |
|
rs4689388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation
|
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
rs4689388
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.820 |
GeneticVariation
|
GWASCAT |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
0.810 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.810 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation
|
BEFREE |
Seven of the 29 single nucleotide polymorphisms (SNPs) examined were found to be associated with T2D risk at P ≤ 0.05, including rs6769511 (IGF2BP2), 2 SNPs in the WFS1 gene (rs4689388 and rs1801214), rs7903146 (TCF7L2), and 3 SNPs in the KCNQ1 gene (rs231362, rs2237892, and rs2237897).
|
23144361 |
2012 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.810 |
GeneticVariation
|
GWASCAT |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
rs1801214
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
0.810 |
GeneticVariation
|
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
rs4458523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.800 |
GeneticVariation
|
GWASDB |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs4458523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
24509480 |
2014 |
|
rs4458523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.800 |
GeneticVariation
|
GWASCAT |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs4458523
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs1553876668
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs1801212
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1801212
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.700 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
rs4416547
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs4688985
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
|
22325160 |
2012 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our results suggested that the G allele of rs734312 polymorphism [dominant: FEM OR 0.873, 95%CI (0.810 - 0.940), recessive: FEM OR 0.876, 95% CI (0.800 - 0.959)] and A allele of rs10010131 polymorphism [dominant:FEM OR 0.853, 95% CI (0.817 - 0.892), recessive:REM OR 0.833, 95% CI (0.756 - 0.917)] in WFS1 gene had significant protective effects on risk of T2D.
|
23257691 |
2013 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
While FTO rs8050136 and rs17817449, ADAMTS9 rs4607103, and WFS1 rs10010131 were initially associated with T2DM, this was lost upon multiple testing correction.
|
24145053 |
2013 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05).
|
23298195 |
2013 |
|
rs10010131
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Cox analyses showed an association between the G-allele of rs10010131 and incident type 2 diabetes (HR 1.34, 95% CI 1.08-1.70, p = 0.007).
|
21127832 |
2011 |