|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
|
23180817 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Interestingly, HLA-DRB1*09:01 has been shown to be associated with multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus, suggesting that either HLA-DRB1*09:01 itself or other genes in tight linkage disequilibrium may play a role in a molecular pathway shared by various autoimmune diseases in Japanese and possibly in other Asian populations.
|
23180035 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*11 had a significant risk for association with a family history of autoimmunity in autistic children (odds ratio: 5.67; 95% CI: 2.07-16.3).
|
23110937 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Conversely, native CII autoimmunity was not associated with any specific DRB1 allele.
|
23160643 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1*15 is a relevant MS susceptibility locus in the Italian population, possibly with little influence on the occurrence of concomitant autoimmune disorders.
|
23279712 |
2013 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
While genome studies map a strong MS susceptibility effect to the region of DRB1*1501, our findings offer a rationale for potential involvement of pathogenic DQ6-associated autoimmunity in MS.
|
22316121 |
2012 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Both generalized and localized vitiligo have the same predisposing major histocompatibility complex alleles, i.e., B*44:03 and DRB1*07:01, in both the populations studied, beside the differences in the frequencies of other alleles, suggesting that localized vitiligo too may be an autoimmune disorder.
|
21833019 |
2012 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Moreover, stratified analyses indicated statistically significant associations between HLA-DRB1*04 allele and anti-cyclic peptides antibodies positivity (ACPA(+)) and rheumatoid factor positivity (RF(+); p(c)=0.03, for both subgroups), HLA-DRBI*10 and ACPA(+) and the presence of another autoimmune disease (p(c)=0.05 and p(c)=0.007, respectively), and HLA-DRB1*04:05 and RF(+) and erosion (p(c)=0.005 and p(c)=0.049; respectively).
|
22349877 |
2012 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
The increased frequency of DRB1*07:01 in North Indian and Gujarat populations with generalized and localized vitiligo and in several vitiligo populations studied previously suggests that it contributes to autoimmunity and destruction of melanocytes.
|
22158608 |
2012 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
In Caucasians, we highlighted the definite protective role of HLA-DRB1*14 and DRB1*07 for MS. DRB1*03 is probably the only risk factor for MS besides DRB1*15 and a common genetic foundation for autoimmune disease.
|
21440682 |
2011 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.
|
20797713 |
2011 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the DRB1*0901 haplotype and the risk alleles of ERBB3, CLEC16A and CTLA4 were positively associated with the co-occurrence of thyroid autoimmunity.
|
22069271 |
2011 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of HLA-DRB1 or HLA-DQB1 are related to production of AAs in autoimmune diseases.
|
21557256 |
2011 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DRB1 and PTPN22 1858T gene variants are risk factors of RA, clinical manifestations and rate of progression of joint destruction in this autoimmune disease.
|
20629510 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Antibodies to citrullinated proteins are associated with HLA 'shared epitope' alleles, and autoimmunity to at least one antigenic sequence, the CEP-1 peptide from citrullinated alpha-enolase (KIHAcitEIFDScitGNPTVE), shows a specific association with HLA-DRB1*0401, *0404, 620W PTPN22, and smoking.
|
20192991 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
Multiple autoimmune disorders (e.g.Addison's disease, type 1 diabetes, celiac disease) are associated with HLA-DR3, but it is likely that alleles of additional genes in linkage disequilibrium with HLA-DRB1 contribute to disease.
|
20631027 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
In our population, over 50% of AG patients carry the HLA-DRB1*03 or *04 alleles associated with autoimmune diseases, suggesting that this subset of AG patients has a genetic predisposition to autoimmunity.
|
20627832 |
2010 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
PTPN22 appears to be primarily associated with anticitrulline autoimmunity, whereas HLA-DRB1 SE is independently associated with RF.
|
19714585 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Rheumatoid arthritis (RA) is an autoimmune disease that affects mostly women and is associated with HLA-DRB1 genes having in common a shared epitope sequence.
|
19117368 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
LHGDN |
Rheumatoid arthritis (RA) is an autoimmune disease that affects mostly women and is associated with HLA-DRB1 genes having in common a shared epitope sequence.
|
19117368 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
Biomarker |
BEFREE |
Our study points to a gene-dose-dependent, protective role for LILRA3, the deletion of which synergizes with HLA-DRB1(*)1501 to increase the risk of R-MS. We also investigated whether the risk of suffering R-MS might be influenced by the genotypic diversity of killer-cell Ig-like receptors (KIRs), located only approximately 400 kb telomeric to LILRA3, and implicated in autoimmunity and defence against viruses.
|
19421224 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele.
|
19675171 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
AlteredExpression |
BEFREE |
These data suggest that the interaction between VDR and HLA alleles is mediated by VDRE present in the promoter region of HLA-DRB1 0301 allele, which may be detrimental for the manifestation of T1D in the absence of 1,25-(OH)(2)D(3) in early childhood due to poor expression of DRB1 0301 in the thymus resulting in autoimmunity.
|
19956544 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens.
|
18954286 |
2009 |
|
HLA-DRB1
|
Autoimmune Diseases
|
0.100 |
GeneticVariation |
BEFREE |
The monomodular-short haplotype with a single C4B gene and the absence of C4A, which is in linkage-disequilibrium with HLA DRB1*0301 in Europeans and a strong risk factor for autoimmune diseases, has a frequency of 0.012 in AIA but 0.106 among healthy European Americans (p=6.6x10(-8)).
|
19135723 |
2009 |