Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.030 AlteredExpression BEFREE Mothers of children with ECC showed higher mean of salivary IL-6 levels compared to those of children without ECC (p = .03). 29246654

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.030 AlteredExpression BEFREE After adjustment, the highest tertiles of IL-6 levels (MR = 1.54, IC = 1.13-2.10, p = 0.005), and NGAL (MR = 1.71, CI = 1.04-2.80, p = 0.032) remained associated to ECC; while TNF-α was no longer associated to ECC (MR = 1.31, CI = 0.98-1.75, p = 0.066). 29895395

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.030 Biomarker BEFREE Significant elevation of IL-6, IL-8 and TNF-α with optimum sensitivity and specificity might imply their involvement as potential non-invasive diagnostic/prognostic markers in ECC. 28579141

2017

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.020 GeneticVariation BEFREE In the crude analyses, the highest tertiles of IL-6 (MR = 1.47, IC = 1.09-2.00, p = 0.012), TNF-α (MR = 1.33, CI = 1.00-1.78, p = 0.040) and NGAL (MR = 2.20, CI = 1.39-3.49, p = 0.001) were associated to ECC. 29895395

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.020 Biomarker BEFREE Significant elevation of IL-6, IL-8 and TNF-α with optimum sensitivity and specificity might imply their involvement as potential non-invasive diagnostic/prognostic markers in ECC. 28579141

2017

Entrez Id: 132320
Gene Symbol: SCLT1
SCLT1
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE Moreover, secreted aspartic protease (Sap) activity and SAP1-5 transcriptional levels were compared in the ECC and caries-free (CF) groups of Uygur children. 30518349

2018

Entrez Id: 1673
Gene Symbol: DEFB4A
DEFB4A
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE Moreover, secreted aspartic protease (Sap) activity and SAP1-5 transcriptional levels were compared in the ECC and caries-free (CF) groups of Uygur children. 30518349

2018

Entrez Id: 2004
Gene Symbol: ELK3
ELK3
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE The strong acidogenicity and aciduricity, Sap activity, and high SAP2 and SAP5 expression might be closely associated with ECC. 30518349

2018

Entrez Id: 5794
Gene Symbol: PTPRH
PTPRH
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE Moreover, secreted aspartic protease (Sap) activity and SAP1-5 transcriptional levels were compared in the ECC and caries-free (CF) groups of Uygur children. 30518349

2018

Entrez Id: 3934
Gene Symbol: LCN2
LCN2
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE After adjustment, the highest tertiles of IL-6 levels (MR = 1.54, IC = 1.13-2.10, p = 0.005), and NGAL (MR = 1.71, CI = 1.04-2.80, p = 0.032) remained associated to ECC; while TNF-α was no longer associated to ECC (MR = 1.31, CI = 0.98-1.75, p = 0.066). 29895395

2018

Entrez Id: 100289462
Gene Symbol: DEFB4B
DEFB4B
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE Moreover, secreted aspartic protease (Sap) activity and SAP1-5 transcriptional levels were compared in the ECC and caries-free (CF) groups of Uygur children. 30518349

2018

Entrez Id: 5660
Gene Symbol: PSAP
PSAP
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE The strong acidogenicity and aciduricity, Sap activity, and high SAP2 and SAP5 expression might be closely associated with ECC. 30518349

2018

Entrez Id: 85444
Gene Symbol: LRRCC1
LRRCC1
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE The strong acidogenicity and aciduricity, Sap activity, and high SAP2 and SAP5 expression might be closely associated with ECC. 30518349

2018

Entrez Id: 2005
Gene Symbol: ELK4
ELK4
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 AlteredExpression BEFREE Moreover, secreted aspartic protease (Sap) activity and SAP1-5 transcriptional levels were compared in the ECC and caries-free (CF) groups of Uygur children. 30518349

2018

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE Significant elevation of IL-6, IL-8 and TNF-α with optimum sensitivity and specificity might imply their involvement as potential non-invasive diagnostic/prognostic markers in ECC. 28579141

2017

Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 GeneticVariation BEFREE Twenty-two children with severe early childhood caries aged 3-6 years were treated with toluoidine blue O (TBO) for 1min and irradiated by a Light Emitting Diode (LED; FotoSan, CMS Dental, Denmark) with the exposure time of 150s. 28359938

2017

Entrez Id: 765
Gene Symbol: CA6
CA6
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE Relationship among α amylase and carbonic anhydrase VI in saliva, visible biofilm, and early childhood caries: a longitudinal study. 27430359

2017

Entrez Id: 54443
Gene Symbol: ANLN
ANLN
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 GeneticVariation BEFREE Genetic polymorphism of scrA gene of Streptococcus mutans isolates is not associated with biofilm formation in severe early childhood caries. 28705197

2017

Entrez Id: 4552
Gene Symbol: MTRR
MTRR
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 GeneticVariation BEFREE The present study aimed to evaluate the association of polymorphisms in genes MTR (rs1805087) and MTRR (rs1801394) with susceptibility of early childhood caries (ECC) and with body mass index alterations. 28118645

2017

Entrez Id: 9048
Gene Symbol: ARTN
ARTN
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE This study assessed cost-effectiveness of the atraumatic restorative treatment-based (ART-based) approach against the standard care (SC) approach to managing early childhood caries in a primary care setting based on a 1-year pragmatic randomized controlled trial. 27859533

2017

Entrez Id: 4548
Gene Symbol: MTR
MTR
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 GeneticVariation BEFREE The present study aimed to evaluate the association of polymorphisms in genes MTR (rs1805087) and MTRR (rs1801394) with susceptibility of early childhood caries (ECC) and with body mass index alterations. 28118645

2017

Entrez Id: 181
Gene Symbol: AGRP
AGRP
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE This study assessed cost-effectiveness of the atraumatic restorative treatment-based (ART-based) approach against the standard care (SC) approach to managing early childhood caries in a primary care setting based on a 1-year pragmatic randomized controlled trial. 27859533

2017

Entrez Id: 1605
Gene Symbol: DAG1
DAG1
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE Model 1 based on DAG 1, showed EBF to be a protective factor against ECC, with an IRR and 95% CI of 0.62 (0.43-0.91). 28631283

2017

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE MMP9 and MMP20 are involved in WSL and ECC development. 26371789

2016

Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
CUI: C3714731
Disease: Early childhood caries
Early childhood caries
0.010 Biomarker BEFREE This study aimed to evaluate the association between polymorphisms in MMP2, MMP3, MMP9, MMP20, TIMP1, and TIMP2 with white spot lesions (WSL) and early childhood caries (ECC). 26371789

2016