Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0263009
Disease: Sclerosis of the skin
Sclerosis of the skin 		0.020 Biomarker BEFREE The reduced progression of skin sclerosis in PGRN-deficient mice was associated with down-regulation of transforming growth factor (TGF)-β receptor I (TβR I) and decreased level of phosphorylated Smad3, with correspondingly impaired expression of its downstream target gene connective tissue growth factor (CTGF) in skin lesion. 31108104

2019
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0263009
Disease: Sclerosis of the skin
Sclerosis of the skin 		0.020 Biomarker BEFREE Progranulin may also be involved in the inflammatory process associated with progressive skin sclerosis in early dcSSc. 26245842

2015