Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. 23056499

2012
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation CLINVAR Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. 22025146

2012
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. 22025146

2012
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation CLINVAR AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. 23056499

2012
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells. 21470995

2011
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Targeted therapies for thyroid tumors. 21455200

2011
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation CLINVAR The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells. 21470995

2011
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. 20368568

2010
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. 20847059

2010
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation CLINVAR Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. 20065189

2010
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. 20065189

2010
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Phase II trial of sorafenib in metastatic thyroid cancer. 19255327

2009
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Phase II trial of sorafenib in advanced thyroid cancer. 18541894

2008
Entrez Id: 5979
Gene Symbol: RET
RET
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 CausalMutation CLINVAR Molecular biology of the MEN2 gene. 9681850

1998
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.680 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.680 CausalMutation CLINVAR Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. 23406027

2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.680 CausalMutation CLINVAR Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. 19773371

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.680 CausalMutation CLINVAR Phase II trial of sorafenib in metastatic thyroid cancer. 19255327

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.680 CausalMutation CLINVAR Hyperactive Ras in developmental disorders and cancer. 17384584

2007
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.480 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.460 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.460 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.460 CausalMutation CLINVAR Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. 23406027

2013
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.460 CausalMutation CLINVAR Phase II trial of sorafenib in metastatic thyroid cancer. 19255327

2009