|
rs731236
|
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four single-nucleotide polymorphisms (SNPs; rs10735810/FokI, rs1544410/BsmI, rs7975232/ApaI, and rs731236/TaqI) in the VDR gene were genotyped in 179 individuals with schizophrenia and 189 healthy controls.
|
16634022 |
2006 |
|
rs731236
|
|
Postsurgical menopause
|
|
0.010 |
GeneticVariation
|
BEFREE |
For rs731236, the CC subjects had a greater chance of surgical menopause than the TT subjects (odds ratio = 2.01, 95% CI 1.07-3.78).
|
17135034 |
2006 |
|
rs731236
|
|
Carcinoma, Ovarian Epithelial
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of ovarian cancer risk with polymorphisms in the vitamin D receptor (VDR) gene, including rs10735810 (FokI), rs11568820 (Cdx-2), rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), and BsmI-ApaI-TaqI combined genotypes, was examined among 313 women with epithelial ovarian carcinoma and 574 controls.
|
18086759 |
2007 |
|
rs731236
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis.
|
18361940 |
2008 |
|
rs731236
|
|
Sporadic Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The synonymous variant rs731236 (TaqI) appeared to be associated with protection from BC (OR = 0.80, 95%CI = 0.64-0.99; p = 0.047).
|
19105801 |
2008 |
|
rs731236
|
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We study the association between three Vitamin D receptor gene polymorphisms (rs10735810, rs1544410, rs731236) and susceptibility to thyroid autoimmune diseases.
|
17943423 |
2008 |
|
rs731236
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
No significant univariate associations between the polymorphisms, rs11574010 (Cdx-2A > G), rs10735810 (Fok1T > C), or rs731236 (Taq1C > T) and MS risk were observed.
|
19383647 |
2009 |
|
rs731236
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
An association of two single-nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, Apal (rs7975232) and Taql (rs731236), with multiple sclerosis (MS) has been reported in a Caucasian population.
|
19758194 |
2009 |
|
rs731236
|
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of the study was to determine whether four VDR gene single nucleotide polymorphisms (SNPs: rs1544410, rs731236, rs10735810 and rs4516035) are associated with breast cancer risk in Polish population.
|
18587672 |
2009 |
|
rs731236
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of the study was to determine whether four VDR gene single nucleotide polymorphisms (SNPs: rs1544410, rs731236, rs10735810 and rs4516035) are associated with breast cancer risk in Polish population.
|
18587672 |
2009 |
|
rs731236
|
|
Malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232), were studied using PCR-RFLP in 137 patients with lung cancer and 156 controls.
|
19644412 |
2009 |
|
rs731236
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232), were studied using PCR-RFLP in 137 patients with lung cancer and 156 controls.
|
19644412 |
2009 |
|
rs731236
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped 100 patients with T1D and 96 controls for the FokI (rs10735810), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis.
|
19734102 |
2009 |
|
rs731236
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232), were studied using PCR-RFLP in 137 patients with lung cancer and 156 controls.
|
19644412 |
2009 |
|
rs731236
|
|
Thyroid carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with thyroid carcinoma (n = 172) (n = 132 for papillary and n = 40 for follicular) and HC (n = 321) were genotyped for the ApaI (rs7975232), TaqI (rs731236), BsmI (rs1544410), and FokI (rs10735810) polymorphisms within the VDR gene and correlated with 25(OH)D(3) and 1,25(OH)(2)D(3) plasma levels.
|
19499989 |
2009 |
|
rs731236
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this study, we investigated whether there was an association of VDR: g.59979G>T or c.1025-49G>T (ApaIG>T) and g.60058T>C or c.1056T>C (TaqIT>C) polymorphisms in the 3' untranslated region of VDR with T2DM in a Turkish population.
|
19186074 |
2010 |
|
rs731236
|
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, rs731236 TT VDR genotype modulates VDR expression and confers protection against MS in HLA-DRB1*15-positive individuals.
|
21664963 |
2011 |
|
rs731236
|
|
Malignant neoplasm of prostate
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also examined vitamin D related genes, VDR and CYP27B1, and found a significant association of PCa with the TaqI polymorphism (rs731236) in the former.
|
21358824 |
2011 |
|
rs731236
|
|
Prostate carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We also examined vitamin D related genes, VDR and CYP27B1, and found a significant association of PCa with the TaqI polymorphism (rs731236) in the former.
|
21358824 |
2011 |
|
rs731236
|
|
Inflammatory Bowel Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Frequencies of the common VDR gene polymorphisms rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case-control analysis of 660 patients with IBD and 699 controls.
|
21818054 |
2011 |
|
rs731236
|
|
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a post-hoc analysis of our previous prospective cohort study, VDR polymorphisms including Cdx2 G/A (rs11568820), FokI C/T (rs10735810), BsmI A/G (rs1544410), ApaI G/T (rs7976091), and TaqI T/C (rs731236) were genotyped by sequencing in 204 consecutive patients with HNSCC who underwent tumor resection.
|
22242137 |
2011 |
|
rs731236
|
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
Most VDR variants (e.g., rs731236/TaqI, rs15444410/BsmI) were not associated with overall risk of NHL, but there was some evidence of a positive association between rs4760655 and follicular lymphoma risk (nominal P(trend) = 0.004, corrected P(trend) = 0.24).
|
21076051 |
2011 |
|
rs731236
|
|
T-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Possible heterogeneity in effects of UVR exposure on T-cell lymphoma risk by VDR rs731236 genotype merits further investigation.
|
21076051 |
2011 |
|
rs731236
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a post-hoc analysis of our previous prospective cohort study, VDR polymorphisms including Cdx2 G/A (rs11568820), FokI C/T (rs10735810), BsmI A/G (rs1544410), ApaI G/T (rs7976091), and TaqI T/C (rs731236) were genotyped by sequencing in 204 consecutive patients with HNSCC who underwent tumor resection.
|
22242137 |
2011 |
|
rs731236
|
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there was some evidence that rs731236 altered associations between UVR and T-cell NHL risk; while increasing UVR frequency lowered T-cell NHL risk among rs731236 TT carriers, an elevated risk was observed among rs731236 CC carriers (nominal P(interaction) ≤ 0.008, corrected P(interaction) ≥ 0.12).
|
21076051 |
2011 |