|
rs731236
|
|
Leprosy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Some polymorphisms of the <i>VDR</i> gene, such as <i>Bsm</i>I (G>A rs1544410)<i>, Apa</i>I (G>T rs7975232), and <i>Taq</i>I (T>C rs731236) could affect its stability and mRNA transcription activity, while <i>Fok</i>I T>C (rs2228570) gives a truncated protein with three fewer amino acids and more efficiency in binding vitamin D. This study evaluated these four polymorphisms in the immunopathogenesis of leprosy in 404 patients and 432 control individuals without chronic or infectious disease in southern Brazil.
|
31636627 |
2019 |
|
rs731236
|
|
Osteopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The presence of the TT allele of the SNP rs2228570 of the VDR gene and the SNP rs731236 of the CC genotype was associated with the presence of osteopenia and decreased bone mineral density alongside malfunctions of vitamin D.
|
30963970 |
2019 |
|
rs731236
|
|
Lumbar disc disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
TaqI (rs731236) polymorphism was associated with a predisposition to LDD.
|
31127184 |
2019 |
|
rs731236
|
|
Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs10735810, rs1544410, rs7975232, and rs731236 were associated with the onset of arthritis at both allelic and genotypic level (p < 0.01).
|
31011579 |
2019 |
|
rs731236
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that VDR rs731236 & rs2228570 or VDBP rs7041 polymorphisms were not risk factors for the development of gastric cancer individually, however, lower serum levels of vitamin D may be a contributory risk for both predisposition and development of gastric cancer.
|
31549372 |
2019 |
|
rs731236
|
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, VDR gene <i>ApaI</i> (rs7975232), <i>BsmI</i> (rs 1544410) and <i>TaqI</i> (rs731236) genotypes were compared in men with osteoporosis and male controls.
|
31448632 |
2019 |
|
rs731236
|
|
Chronic Periodontitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no significant association between genotype/phenotype of VDBP's SNPs (rs7041 and rs4588) and occurrence of chronic periodontitis (p value = 0.401) Moreover, no statistically significant association was found between chronic periodontitis and Taq1 (rs731236) (p value = 0.401) and Apa1 (rs7975232) (p value = 0.248).
|
30083974 |
2019 |
|
rs731236
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results indicate that VDR rs731236 & rs2228570 or VDBP rs7041 polymorphisms were not risk factors for the development of gastric cancer individually, however, lower serum levels of vitamin D may be a contributory risk for both predisposition and development of gastric cancer.
|
31549372 |
2019 |
|
rs731236
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Vitamin D receptor ApaI (rs7975232), BsmI (rs1544410), Fok1 (rs2228570), and TaqI (rs731236) gene polymorphisms and susceptibility to pulmonary tuberculosis in an Iranian population: A systematic review and meta-analysis.
|
31740220 |
2019 |
|
rs731236
|
|
Thromboangiitis Obliterans
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study aimed to evaluate the association of selected <i>VDR</i> polymorphisms (rs2228570, rs1544410, rs7975232, rs731236, and rs11568820) with susceptibility to TAO.
|
31424978 |
2019 |
|
rs731236
|
|
Lhermitte-Duclos disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
TaqI (rs731236) polymorphism was associated with a predisposition to LDD.
|
31127184 |
2019 |
|
rs731236
|
|
Myopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC-genotype of the VDR polymorphism TaqI rs731236 has previously been associated with a higher risk of developing myopathy compared to TT-carriers.
|
31252402 |
2019 |
|
rs731236
|
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The currently available data fails to support a robust association between VDR rs7975232, rs1544410, rs2228570 and rs731236 polymorphisms and psoriasis susceptibility, which still required the support of more case-control studies.
|
31623568 |
2019 |
|
rs731236
|
|
Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis was conducted to assess the association of VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphisms with RCC risk.
|
29970659 |
2018 |
|
rs731236
|
|
Osteoporosis, Postmenopausal
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the bearers of C-G-C haplotype (consisting of rs7975232, rs1544410, and rs731236 unfavorable alleles), the risk of PMO was significantly higher (OR = 4.7, 95% CI 2.8-8.1, <i>p</i> < 0.0001) compared to controls.
|
29922235 |
2018 |
|
rs731236
|
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The overall results indicated that <i>VDR</i> rs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD.
|
29765404 |
2018 |
|
rs731236
|
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The synonymous single nucleotide polymorphism (SNP) rs731236, located in the VDR gene, has been associated with a higher risk of Crohn's disease (CD).
|
29788141 |
2018 |
|
rs731236
|
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs731236 polymorphism is associated with the risk of primary OA of the knee in Mexican Mestizo population.
|
30657057 |
2018 |
|
rs731236
|
|
Sepsis of the newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis.
|
29530503 |
2018 |
|
rs731236
|
|
Hypercholesterolemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs731236 variant was shown to be associated with high cholesterol and LDL-cholesterol levels in T2DM patients, while rs1544410 was associated with lower BMI and lower LDL cholesterol levels.
|
28323045 |
2018 |
|
rs731236
|
|
Arteriovenous fistula
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the influence of the vitamin D receptor gene TaqI (rs731236), ApaI (rs7975232), and FokI (rs2228570) polymorphisms in arteriovenous fistula failure in hemodialysis patients.
|
29544394 |
2018 |
|
rs731236
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis was conducted to assess the association of VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphisms with RCC risk.
|
29970659 |
2018 |
|
rs731236
|
|
Bacterial sepsis of newborn
|
|
0.010 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association of VDR polymorphism at FokI, rs2228570 T/C, and TaqI, rs731236 C/T gene with serum 25-hydroxyvitamin D level and risk of neonatal sepsis.
|
29530503 |
2018 |
|
rs731236
|
|
Primary sclerosing cholangitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the incidence of VDR polymorphisms (rs1544410-BsmI; rs7975232-ApaI; rs731236-TaqI) in a group of patients with primary sclerosing cholangitis (PSC, n = 275) and in healthy controls (n = 376).
|
28426778 |
2017 |
|
rs731236
|
|
Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The effect of vitamin D3 supplementation on advanced adenomas, but not on adenoma risk overall, significantly varied according to genotype at 2 VDR SNPs (rs7968585 and rs731236) in linkage disequilibrium (D' = 0.98; r2 = 0.6).
|
27978548 |
2017 |