|
rs2069705
|
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model.
|
19919944 |
2010 |
|
rs2069705
|
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model.
|
19919944 |
2010 |
|
rs2430561
|
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model.
|
19919944 |
2010 |
|
rs2069718
|
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model.
|
19919944 |
2010 |
|
rs2069718
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model.
|
19919944 |
2010 |
|
rs771694484
|
|
IMMUNODEFICIENCY 32B
|
|
0.010 |
GeneticVariation
|
BEFREE |
Autosomal recessive IRF8 deficiency is caused by mutation K108E and associated with severe disease with complete depletion of monocytes and dendritic cells.
|
23468103 |
2013 |
|
rs2430561
|
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs2430561 does not seem to have any role in ITP pathogenesis and treatment response.
|
30955035 |
2019 |
|
rs2430561
|
|
Tuberculosis, extrapulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
A trial sequential meta-analysis of IFN-γ +874 A>T (rs2430561) gene polymorphism and extrapulmonary tuberculosis risk.
|
30825502 |
2019 |
|
rs1861493
|
|
AURAL ATRESIA, CONGENITAL
|
|
0.010 |
GeneticVariation
|
BEFREE |
AA allele frequencies of rs1861493 were also associated with a significantly higher risk of CAA in KD patients.
|
27124053 |
2016 |
|
rs2069705
|
|
Mixed Connective Tissue Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the seven tested SNPs, four polymorphisms: IFN-A rs10757212, IFN-A rs3758236, IFN-G rs2069705, IFN-G rs2069718, as well as INF-G rs1861493A/rs2069705A/rs2069718G haplotype were significantly associated with a predisposition for MCTD.
|
31766529 |
2019 |
|
rs2069705
|
|
Buruli Ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
By typing a cohort of 96 Ghanaian BU patients and 384 endemic controls without BU, we show an association between BU and single nucleotide polymorphisms (SNPs) in <i>iNOS</i> (rs9282799) and <i>IFNG</i> (rs2069705).
|
29046669 |
2017 |
|
rs2069727
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |
|
rs2430561
|
|
Leukemia, Myelocytic, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia.
|
31373163 |
2019 |
|
rs2430561
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from previous studies about the association between interferon gamma (IFN-γ) +874 T/A (rs2430561) polymorphism and cervical cancer risk offer controversial results.
|
25649976 |
2015 |
|
rs2430561
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from previous studies about the association between interferon gamma (IFN-γ) +874 T/A (rs2430561) polymorphism and cervical cancer risk offer controversial results.
|
25649976 |
2015 |
|
rs2430561
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from previous studies about the association between interferon gamma (IFN-γ) +874 T/A (rs2430561) polymorphism and cervical cancer risk offer controversial results.
|
25649976 |
2015 |
|
rs1861494
|
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eighty-five patients with vitiligo and 90 controls were investigated for IFN-γ gene expression by quantitative real-time PCR and genotyped for IFN-γ +874T/A (rs2430561) and IFN-γ +2109A/G (rs1861494) gene polymorphisms by sequence-specific primer (SSP)-PCR and PCR-restriction fragment length polymorphism (RFLP), respectively.
|
28273427 |
2017 |
|
rs1861494
|
|
Vitiligo
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eighty-five patients with vitiligo and 90 controls were investigated for IFN-γ gene expression by quantitative real-time PCR and genotyped for IFN-γ +874T/A (rs2430561) and IFN-γ +2109A/G (rs1861494) gene polymorphisms by sequence-specific primer (SSP)-PCR and PCR-restriction fragment length polymorphism (RFLP), respectively.
|
28273427 |
2017 |
|
rs2069705
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, we verified higher IL-6 value in the RA patients than healthy control group (p = 0.007) and an association between high IL-6 levels and increased CDAI (r = 0.4648, p = 0.0015); DAS 28 (r = 0.3933, p= 0.0091), presence of bone erosions (r = 0.3170, p = 0.0361), ESR levels(r = 0.3041, p = 0.0448) and IFN-γ levels (r = 0.3049, p = 0.0468).Altogether, we suggest that IL10 -1082 (T>C, rs1800896) and INFG -1616(A>G, rs2069705) polymorphisms as well as IL-6 levels alterations may play a role for prognostic and disease follow-up.
|
31494241 |
2020 |
|
rs2069705
|
|
Refractory anemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, we verified higher IL-6 value in the RA patients than healthy control group (p = 0.007) and an association between high IL-6 levels and increased CDAI (r = 0.4648, p = 0.0015); DAS 28 (r = 0.3933, p= 0.0091), presence of bone erosions (r = 0.3170, p = 0.0361), ESR levels(r = 0.3041, p = 0.0448) and IFN-γ levels (r = 0.3049, p = 0.0468).Altogether, we suggest that IL10 -1082 (T>C, rs1800896) and INFG -1616(A>G, rs2069705) polymorphisms as well as IL-6 levels alterations may play a role for prognostic and disease follow-up.
|
31494241 |
2020 |
|
rs2069705
|
|
Superficial ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, we verified higher IL-6 value in the RA patients than healthy control group (p = 0.007) and an association between high IL-6 levels and increased CDAI (r = 0.4648, p = 0.0015); DAS 28 (r = 0.3933, p= 0.0091), presence of bone erosions (r = 0.3170, p = 0.0361), ESR levels(r = 0.3041, p = 0.0448) and IFN-γ levels (r = 0.3049, p = 0.0468).Altogether, we suggest that IL10 -1082 (T>C, rs1800896) and INFG -1616(A>G, rs2069705) polymorphisms as well as IL-6 levels alterations may play a role for prognostic and disease follow-up.
|
31494241 |
2020 |
|
rs2069705
|
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Further pooled analysis with Korean populations involving 10498 subjects showed a more significant association between rs2069705 and SLE (T vs. C: OR = 1.11, 95%CI = 1.04-1.19, P = 0.002; TT + TC vs. CC: OR = 1.11, 95%CI = 1.02-1.21, P = 0.012; TT vs. TC + CC: OR = 1.28, 95%CI = 1.07-1.54, P = 0.008; TT vs. CC: OR = .33, 95%CI = 1.10-1.60, P = 0.003).
|
26916970 |
2016 |
|
rs2430561
|
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Further studies with larger sample sizes and consideration of gene-environment interactions should be conducted to elucidate the role of <i>IFNG</i> +874 T/A(rs2430561) polymorphism in tuberculosis susceptibility.
|
28881572 |
2017 |
|
rs2430561
|
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the <i>IFNG</i> +874 T/A(rs2430561)polymorphism played an important role in protecting individuals from both pulmonary tuberculosis and extra-pulmonary tuberculosis.
|
28881572 |
2017 |
|
rs2430561
|
|
Tuberculosis
|
|
0.060 |
GeneticVariation
|
BEFREE |
Given its key role in the control of tuberculosis (TB), in the present article we have investigated a possible association between IFN-γ gene single-nucleotide polymorphism linked to high and low producer phenotypes (IFN-γ [+874T(high) → A(low)]) (rs2430561) and risk development of active TB in Tunisian patients.
|
21332391 |
2011 |