|
rs1861493
|
|
Mucocutaneous Lymph Node Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele of rs1861493 conferred a better response to IVIG treatment in KD patients.
|
27124053 |
2016 |
|
rs1861493
|
|
AURAL ATRESIA, CONGENITAL
|
|
0.010 |
GeneticVariation
|
BEFREE |
AA allele frequencies of rs1861493 were also associated with a significantly higher risk of CAA in KD patients.
|
27124053 |
2016 |
|
rs1861493
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyze the association of a (CA)n repeat in intron 1 and six single nucleotide polymorphisms (((rs2069705, T/C) (promoter)), ((rs1861494, A/G), (rs1861493, T/C), (rs2069718, C/T) (intron 3)), ((rs2069727, A/G) and (rs2069728, G/A) (3' untranslated region))) spanning the whole gene with asthma.
|
18385742 |
2008 |
|
rs1861493
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using multiple corrections, significant overall risk against PTB was observed at seven loci which included variants in IFNG at rs1861493 and rs1861494; IL1RA at rs4252019, IL4 variant rs2070874, IL12 variants rs3212220, rs2853694 and TNFB variant rs1041981.
|
22771610 |
2012 |
|
rs1861494
|
|
Tuberculosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Three IFN-γ polymorphisms in intron 3, rs1861494 and rs2069718, and rs2430561 in interon 1 were strongly associated with TB.
|
24529854 |
2015 |
|
rs1861494
|
|
Tuberculosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population.
|
29361774 |
2018 |
|
rs1861494
|
|
Tuberculosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
IFNG rs1861494 polymorphism was associated with TB, particularly in the younger and male subgroups.
|
31310896 |
2019 |
|
rs1861494
|
|
Latent Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>IFNG</i> rs1861494 was significantly associated with LTBI in recessive model, and the CC+CT genotype decreased risk of LTBI by 50% (<i>P</i> = 0.046, OR = 0.50, 95%CI: 0.25-0.99).
|
31687049 |
2019 |
|
rs1861494
|
|
Stress, Psychological
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicate that firstly the genetic variant of IFNγ (rs1861494) is involved with the regulation of amygdala reactivity to emotional stimuli and secondly, that this genetic variant moderates effects of early life stress on emotion processing.
|
26313134 |
2015 |
|
rs1861494
|
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we report for the first time association of rs1861494 A/G polymorphism with asthma, which may regulate the IFNgamma levels and, hence, modulate asthma pathogenesis.
|
18385742 |
2008 |
|
rs1861494
|
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study reports the first association of IFNG rs1861494 T allele with enhanced IFN-γ secretion and known IBD clinical parameters indicative of more aggressive disease and serological markers associated with treatment resistance to anti-tumor necrosis factor therapy in patients with IBD.
|
25171510 |
2014 |
|
rs1861494
|
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.
|
25171510 |
2014 |
|
rs1861494
|
|
Allergic asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report here the association of rs1861494 A/G with atopic asthma in a case-control cohort (n=189 and n=270 cases and controls, respectively) (P=0.0006), which was replicated (P=0.006) in a family study (n=137) as well.
|
18385742 |
2008 |
|
rs1861494
|
|
Hamartoma Syndrome, Multiple
|
|
0.010 |
GeneticVariation
|
BEFREE |
Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.
|
25171510 |
2014 |
|
rs1861494
|
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Peripheral T cells of UC and Crohn's disease (CD) patients were genotyped for rs1861494 and analyzed for allele-specific and IFNG promoter methylation.
|
25171510 |
2014 |
|
rs1861494
|
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eighty-five patients with vitiligo and 90 controls were investigated for IFN-γ gene expression by quantitative real-time PCR and genotyped for IFN-γ +874T/A (rs2430561) and IFN-γ +2109A/G (rs1861494) gene polymorphisms by sequence-specific primer (SSP)-PCR and PCR-restriction fragment length polymorphism (RFLP), respectively.
|
28273427 |
2017 |
|
rs1861494
|
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters.
|
28391282 |
2017 |
|
rs1861494
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using multiple corrections, significant overall risk against PTB was observed at seven loci which included variants in IFNG at rs1861493 and rs1861494; IL1RA at rs4252019, IL4 variant rs2070874, IL12 variants rs3212220, rs2853694 and TNFB variant rs1041981.
|
22771610 |
2012 |
|
rs1861494
|
|
Vitiligo
|
|
0.010 |
GeneticVariation
|
BEFREE |
Eighty-five patients with vitiligo and 90 controls were investigated for IFN-γ gene expression by quantitative real-time PCR and genotyped for IFN-γ +874T/A (rs2430561) and IFN-γ +2109A/G (rs1861494) gene polymorphisms by sequence-specific primer (SSP)-PCR and PCR-restriction fragment length polymorphism (RFLP), respectively.
|
28273427 |
2017 |
|
rs1861494
|
|
IgE-mediated allergic asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report here the association of rs1861494 A/G with atopic asthma in a case-control cohort (n=189 and n=270 cases and controls, respectively) (P=0.0006), which was replicated (P=0.006) in a family study (n=137) as well.
|
18385742 |
2008 |
|
rs1861494
|
|
Irritable Bowel Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion.
|
25171510 |
2014 |
|
rs2069705
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The association of IFN-γ rs2069705 with the risk of breast cancer was not significant among all participants, while the CT/TT genotypes were significantly related to an elevated risk of breast cancer [1.32 (1.03-1.70)] among the women with <1 fever per year and to a reduced risk of breast cancer [0.63 (0.40-0.99)] among women with ≥1 fever per year compared to the CC genotype.
|
22624006 |
2012 |
|
rs2069705
|
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model.
|
19919944 |
2010 |
|
rs2069705
|
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
IFN-γ rs2069705 was not directly associated with BC risk but interacted with EBNA-1 IgA on BC risk.
|
22095765 |
2012 |
|
rs2069705
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
IFN-γ rs2069705 was not directly associated with BC risk but interacted with EBNA-1 IgA on BC risk.
|
22095765 |
2012 |