|
rs1022088103
|
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mutational analysis of Nm23-H1 revealed that substitution mutants P96S and S120G did not inhibit motility and invasion.
|
17671192 |
2007 |
|
rs1132896
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPStats, Haploview was used to analyze genetic data.Two SNPs in the MMP-2 gene were significantly associated with stroke risk.For rs1132896 (C versus G allele), the C allele was significantly reduced stroke risk (OR = 0.56, 95% confidence intervals [95% CI] = 0.39-0.81, P = .002).
|
30278505 |
2018 |
|
rs11639960
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, two of these SNPs (rs17301608 and rs11639960) were examined and were not associated with prostate cancer</span> in a recent genome-wide association study using prostate cancer cases and controls from the Prostate, Lung, Colorectal, and Ovary study cohort.
|
18398039 |
2008 |
|
rs11639960
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, two of these SNPs (rs17301608 and rs11639960) were examined and were not associated with prostate cancer</span> in a recent genome-wide association study using prostate cancer cases and controls from the Prostate, Lung, Colorectal, and Ovary study cohort.
|
18398039 |
2008 |
|
rs11643630
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele homozygotes for rs11644561 (G/A) were found to have a decreased risk of breast cancer [odds ratio (OR), 0.6; 95% confidence interval (CI), 0.3-1.0] compared with major allele homozygotes, as were minor allele homozygotes for rs11643630 (T/G) compared with major allele homozygotes (OR, 0.8; 95% CI, 0.7-1.0).
|
19454611 |
2009 |
|
rs11643630
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele homozygotes for rs11644561 (G/A) were found to have a decreased risk of breast cancer [odds ratio (OR), 0.6; 95% confidence interval (CI), 0.3-1.0] compared with major allele homozygotes, as were minor allele homozygotes for rs11643630 (T/G) compared with major allele homozygotes (OR, 0.8; 95% CI, 0.7-1.0).
|
19454611 |
2009 |
|
rs11644561
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele homozygotes for rs11644561 (G/A) were found to have a decreased risk of breast cancer [odds ratio (OR), 0.6; 95% confidence interval (CI), 0.3-1.0] compared with major allele homozygotes, as were minor allele homozygotes for rs11643630 (T/G) compared with major allele homozygotes (OR, 0.8; 95% CI, 0.7-1.0).
|
19454611 |
2009 |
|
rs11644561
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor allele homozygotes for rs11644561 (G/A) were found to have a decreased risk of breast cancer [odds ratio (OR), 0.6; 95% confidence interval (CI), 0.3-1.0] compared with major allele homozygotes, as were minor allele homozygotes for rs11643630 (T/G) compared with major allele homozygotes (OR, 0.8; 95% CI, 0.7-1.0).
|
19454611 |
2009 |
|
rs11646643
|
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs243864 (OR: 7.44; 95% CI: 3.62-15.26) and rs11646643 (OR: 1.58; 95% CI: 1.07-2.34) of the MMP-2 gene and rs3918253 (OR: 1.72; 95% CI: 1.08-2.71) of the MMP-9 gene, were associated with the risk of COPD.
|
26439471 |
2015 |
|
rs121912955
|
|
Winchester syndrome (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
We report a homozygous missense mutation (E404K) in the active site of MMP2 in a 21-year-old woman with a severe form of osteolysis best compatible with a diagnosis of Winchester syndrome.
|
15691365 |
2005 |
|
rs1231584616
|
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Mutational analysis of Nm23-H1 revealed that substitution mutants P96S and S120G did not inhibit motility and invasion.
|
17671192 |
2007 |
|
rs1238968510
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Decreases in the MMP-2 (-735) polymorphism GG genotype and increases in the MMP-13 (A77G) polymorphism AG and GG genotypes increase the risk for lung cancer.
|
23465389 |
2013 |
|
rs1238968510
|
|
Lung Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
When we compared polymorphisms pertaining to MMP genes in healthy controls and lung tumor DNA, we observed a decrease in the MMP-2 (-735) polymorphism GG genotype and increases in the MMP-13 (A77G) polymorphism AG and GG genotypes (P = 0.008, P = 0.047, and P = 0.047, respectively).
|
23465389 |
2013 |
|
rs1238968510
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Decreases in the MMP-2 (-735) polymorphism GG genotype and increases in the MMP-13 (A77G) polymorphism AG and GG genotypes increase the risk for lung cancer.
|
23465389 |
2013 |
|
rs1238968510
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Decreases in the MMP-2 (-735) polymorphism GG genotype and increases in the MMP-13 (A77G) polymorphism AG and GG genotypes increase the risk for lung cancer.
|
23465389 |
2013 |
|
rs12934241
|
|
Leukopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The variant homozygotes of reference SNP rs12934241 exhibited the most significant effect on the risk of neutropenia, leading to an incidence rate that increased from 12.3% (for the C/C genotype) to 50% (for the T/T genotype; odds ratio, 8.33; P = 8.8 × 10(-5)).
|
22072145 |
2012 |
|
rs12934241
|
|
Neutropenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The variant homozygotes of reference SNP rs12934241 exhibited the most significant effect on the risk of neutropenia, leading to an incidence rate that increased from 12.3% (for the C/C genotype) to 50% (for the T/T genotype; odds ratio, 8.33; P = 8.8 × 10(-5)).
|
22072145 |
2012 |
|
rs14070
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Increasing urinary cadmium concentrations were positively associated with hypertension risk in a Chinese population, and the associations were modified by polymorphism of rs14070 and rs7201 in gene MMP-2.
|
30684802 |
2019 |
|
rs142319636
|
|
Colorectal Carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
We discovered 17 variants across 4 independent regions that merit further investigation due to suggestive CRC associations (P < 1×10(-6)) at 1p34.3 (rs7528276; Odds Ratio (OR) = 1.86 [95% confidence interval (CI): 1.47-2.36); P = 2.5×10(-7)], 2q23.3 (rs1367374; OR = 1.37 (95% CI: 1.21-1.55); P = 4.0×10(-7)), 14q24.2 (rs143046984; OR = 1.65 (95% CI: 1.36-2.01); P = 4.1×10(-7)) and 16q12.2 [rs142319636; OR = 1.69 (95% CI: 1.37-2.08); P=7.8×10(-7)].
|
27207650 |
2016 |
|
rs1477017
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the MMP2 gene, three intronic SNPs, all in linkage disequilibrium, were associated with overall and advanced prostate cancer (for overall prostate cancer, P(trend) = 0.01 for rs1477017, P(trend) = 0.01 for rs17301608, P(trend) = 0.02 for rs11639960).
|
18398039 |
2008 |
|
rs1477017
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the MMP2 gene, three intronic SNPs, all in linkage disequilibrium, were associated with overall and advanced prostate cancer (for overall prostate cancer, P(trend) = 0.01 for rs1477017, P(trend) = 0.01 for rs17301608, P(trend) = 0.02 for rs11639960).
|
18398039 |
2008 |
|
rs17301608
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, two of these SNPs (rs17301608 and rs11639960) were examined and were not associated with prostate cancer</span> in a recent genome-wide association study using prostate cancer cases and controls from the Prostate, Lung, Colorectal, and Ovary study cohort.
|
18398039 |
2008 |
|
rs17301608
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, two of these SNPs (rs17301608 and rs11639960) were examined and were not associated with prostate cancer</span> in a recent genome-wide association study using prostate cancer cases and controls from the Prostate, Lung, Colorectal, and Ovary study cohort.
|
18398039 |
2008 |
|
rs17859821
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).
|
19295411 |
2009 |
|
rs17859821
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
The findings of the present study suggest that MMP-2 rs17859821 A allele was associated with better prognosis of systolic HF in the northern Han Chinese population.
|
19332048 |
2009 |