|
rs17859821
|
|
Congenital infectious disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed that mutations in rs11244787 and rs1871054 (in ADAM12) and rs243866, rs17859821, and rs2285053 (in MMP2) were associated with susceptibility to congenital infection.
|
26597259 |
2016 |
|
rs2285053
|
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined.
|
31243109 |
2019 |
|
rs2285053
|
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed significantly increased susceptibility to NPC for the MMP2 -1306CC (rs243865:C>T) (odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.30-3.10) and -735CC (rs2285053:C>T) (OR = 1.56, 95% CI = 1.17-2.09) genotype carriers compared with noncarriers in the Guangxi population.
|
17607721 |
2007 |
|
rs2285053
|
|
Congenital infectious disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Logistic regression analysis showed that mutations in rs11244787 and rs1871054 (in ADAM12) and rs243866, rs17859821, and rs2285053 (in MMP2) were associated with susceptibility to congenital infection.
|
26597259 |
2016 |
|
rs2285053
|
|
Resistant hypertensive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in matrix metalloproteinase 2 (MMP-2) gene [-1575G/A (rs243866); -1306C/T (rs243865); and -735C/T (rs2285053)] are associated with several CV conditions, however the relationship between MMP-2 polymorphisms and resistant hypertension (RH) is unknown.
|
28390988 |
2017 |
|
rs2285053
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs2285053 was negatively associated with triple negativity, tumor size, distance metastasis, molecular type, and chemotherapy.
|
31014197 |
2019 |
|
rs2285053
|
|
Childhood Leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aimed to determine the role of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes in childhood leukemia risk.
|
30842148 |
2019 |
|
rs2285053
|
|
Pediatric Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether traditional MRFs and two MMP-2 gene polymorphisms (C(-1306)T; rs243865, and C(-735)T; rs2285053) affect circulating MMP-2 levels in children and adolescents, and whether MMP-2 polymorphisms and/or haplotype are associated with susceptibility to childhood obesity.
|
23242659 |
2013 |
|
rs2285053
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele frequency of rs2285053 was significantly lower in women with breast cancer cases as compared to control women; minor allele frequencies of the remaining single-nucleotide polymorphisms were similar between cases and control women.
|
31014197 |
2019 |
|
rs2285053
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The minor allele frequency of rs2285053 was significantly lower in women with breast cancer cases as compared to control women; minor allele frequencies of the remaining single-nucleotide polymorphisms were similar between cases and control women.
|
31014197 |
2019 |
|
rs2285053
|
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We explored the association of MMP2 (C-735T, rs2285053), MMP7 (A-181G, rs11568818) and MMP9 (R279Q, rs17576), (P574R, rs2250889), (R668Q, rs17577) genetic variants with LVD in coronary artery disease (CAD) patients.
|
22664146 |
2012 |
|
rs2285053
|
|
Rheumatic disease of mitral valve
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, rs3918242 MMP-9 and rs2285053 MMP-2 SNPs were significantly represented in cases than two control groups and were associated with a higher MVD risk, as demonstrated using dominant/recessive models.
|
27288746 |
2017 |
|
rs2285053
|
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study, MMP2 promoter 1306 (rs243865) and -735 (rs2285053) genotypes and their interaction with consumption of areca, cigarettes, and alcohol in determining oral cancer risk were investigated among 788 patients with oral cancer and 956 gender-matched healthy controls.
|
30504396 |
2018 |
|
rs2285053
|
|
Diseases of mitral valve
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, rs3918242 MMP-9 and rs2285053 MMP-2 SNPs were significantly represented in cases than two control groups and were associated with a higher MVD risk, as demonstrated using dominant/recessive models.
|
27288746 |
2017 |
|
rs2285053
|
|
Neoplasm Metastasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, rs2285053 was negatively associated with triple negativity, tumor size, distance metastasis, molecular type, and chemotherapy.
|
31014197 |
2019 |
|
rs2285053
|
|
Anthracosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association of three functional polymorphisms in MMP gene promoters (MMP1 rs1799750, MMP2 rs2285053 and MMP3 rs522616) with the risk of CWP.
|
26528997 |
2015 |
|
rs2285053
|
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this case-control study, MMP2 promoter 1306 (rs243865) and -735 (rs2285053) genotypes and their interaction with consumption of areca, cigarettes, and alcohol in determining oral cancer risk were investigated among 788 patients with oral cancer and 956 gender-matched healthy controls.
|
30504396 |
2018 |
|
rs2287074
|
|
Dental caries
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyse MMP2 (rs2287074) and MMP3 (rs679620) single nucleotide polymorphisms (SNPs) and their role in caries susceptibility.
|
27043485 |
2016 |
|
rs2287074
|
|
Caries (morphologic abnormality)
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to analyse MMP2 (rs2287074) and MMP3 (rs679620) single nucleotide polymorphisms (SNPs) and their role in caries susceptibility.
|
27043485 |
2016 |
|
rs2287074
|
|
Dental Fluorosis, Acquired
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant correlation was also found between the genotype of MMP2 rs2287074 and skeletal fluorosis severity.
|
28079131 |
2017 |
|
rs2287074
|
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
The role of MMP2 r</span>s2287074 in ARM should be further elucidated.
|
18359774 |
2008 |
|
rs243832
|
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
We did not found any strong linkage between the six SNPs (rs1132896, rs1053605, rs243849, rs243847, rs243832, rs7201)The results presented strongly indicate that MMP-2 genetic variants are an important mediator of stroke risk.
|
30278505 |
2018 |
|
rs243847
|
|
Intracranial Aneurysm
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, two SNPs, rs243847 (P = 0.00086) and rs243865 (P = 0.00090), on matrix metallopeptidase 2 (MMP2) gene and one SNP rs1799724 (P = 0.0026) on tumor necrosis factor-α (TNF-α) gene, are marginally associated with IA in male- and female-specific manner, respectively.
|
21228795 |
2011 |
|
rs243864
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).
|
19295411 |
2009 |
|
rs243864
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
MMP-2 rs243866, rs243864 had no association with systolic HF prognosis.
|
19332048 |
2009 |