|
rs243865
|
|
Lip and Oral Cavity Carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this case-control study, MMP2 promoter 1306 (rs243865) and -735 (rs2285053) genotypes and their interaction with consumption of areca, cigarettes, and alcohol in determining oral cancer risk were investigated among 788 patients with oral cancer and 956 gender-matched healthy controls.
|
30504396 |
2018 |
|
rs243865
|
|
Lip and Oral Cavity Carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Our data indicated genotypes and alleles in specific SNPs rs9849237, rs243865 and rs10090787 with increased/decreased risk to oral cancer.
|
28595731 |
2017 |
|
rs142319636
|
|
Colorectal Carcinoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
We discovered 17 variants across 4 independent regions that merit further investigation due to suggestive CRC associations (P < 1×10(-6)) at 1p34.3 (rs7528276; Odds Ratio (OR) = 1.86 [95% confidence interval (CI): 1.47-2.36); P = 2.5×10(-7)], 2q23.3 (rs1367374; OR = 1.37 (95% CI: 1.21-1.55); P = 4.0×10(-7)), 14q24.2 (rs143046984; OR = 1.65 (95% CI: 1.36-2.01); P = 4.1×10(-7)) and 16q12.2 [rs142319636; OR = 1.69 (95% CI: 1.37-2.08); P=7.8×10(-7)].
|
27207650 |
2016 |
|
rs243865
|
|
Prostate carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Meta-analysis showed no associations between MMP1 rs1799750, MMP2 rs243865, or MMP7 rs11568818 and prostate cancer risk overall.
|
30464622 |
2018 |
|
rs243865
|
|
Malignant neoplasm of prostate
|
|
0.030 |
GeneticVariation
|
BEFREE |
Meta-analysis showed no associations between MMP1 rs1799750, MMP2 rs243865, or MMP7 rs11568818 and prostate cancer risk overall.
|
30464622 |
2018 |
|
rs243865
|
|
Prostate carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
MMP2 -1306 C > T (rs243865) polymorphism was not significantly related with prostate cancer susceptibility in Iranian men.
|
27541146 |
2017 |
|
rs243865
|
|
Malignant neoplasm of prostate
|
|
0.030 |
GeneticVariation
|
BEFREE |
MMP2 -1306 C > T (rs243865) polymorphism was not significantly related with prostate cancer susceptibility in Iranian men.
|
27541146 |
2017 |
|
rs243865
|
|
Prostate carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis results suggest that <i>MMP2</i> rs243865 polymorphisms are significantly associated with higher risk of prostate cancer.
|
29069837 |
2017 |
|
rs243865
|
|
Malignant neoplasm of prostate
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our meta-analysis results suggest that <i>MMP2</i> rs243865 polymorphisms are significantly associated with higher risk of prostate cancer.
|
29069837 |
2017 |
|
rs17859821
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).
|
19295411 |
2009 |
|
rs17859821
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
The findings of the present study suggest that MMP-2 rs17859821 A allele was associated with better prognosis of systolic HF in the northern Han Chinese population.
|
19332048 |
2009 |
|
rs2285053
|
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined.
|
31243109 |
2019 |
|
rs2285053
|
|
Nasopharyngeal carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We observed significantly increased susceptibility to NPC for the MMP2 -1306CC (rs243865:C>T) (odds ratio [OR] = 2.01, 95% confidence interval [CI] = 1.30-3.10) and -735CC (rs2285053:C>T) (OR = 1.56, 95% CI = 1.17-2.09) genotype carriers compared with noncarriers in the Guangxi population.
|
17607721 |
2007 |
|
rs243864
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).
|
19295411 |
2009 |
|
rs243864
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
MMP-2 rs243866, rs243864 had no association with systolic HF prognosis.
|
19332048 |
2009 |
|
rs243865
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs243865 MMP-2 polymorphism was not associated with an increased risk of developing AMD.
|
30845235 |
2019 |
|
rs243865
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Carriers of rs243865 T allele and rs243866 A allele in MMP-2 were suggested to have increased risks of hypertension.
|
30684802 |
2019 |
|
rs243865
|
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this case-control study, MMP2 promoter 1306 (rs243865) and -735 (rs2285053) genotypes and their interaction with consumption of areca, cigarettes, and alcohol in determining oral cancer risk were investigated among 788 patients with oral cancer and 956 gender-matched healthy controls.
|
30504396 |
2018 |
|
rs243865
|
|
Intracranial Aneurysm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study demonstrated an association between the functional MMP-2 rs243865 variant and IAs.
|
29334797 |
2018 |
|
rs243865
|
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs243865 T allele was associated with IA presence in univariate (OR 1.18 [95% CI 1.04-1.33], p = .01) and in multi-variable analyses adjusted for smoking and hypertension status (OR 1.16 [95% CI 1.01-1.35], p = .042).
|
29334797 |
2018 |
|
rs243865
|
|
Age related macular degeneration
|
|
0.020 |
GeneticVariation
|
BEFREE |
GA + AA genotypes of rs243866 SNP may associate with a decreased risk of AMD in the age≤65 years subgroup (P = .028, OR = 0.399, 95% CI = 0.174-0.915).MMP-2 gene rs243865 and rs243866 SNPs associated with the risk of AMD.
|
29381911 |
2017 |
|
rs243865
|
|
Malignant neoplasm of mouth
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data indicated genotypes and alleles in specific SNPs rs9849237, rs243865 and rs10090787 with increased/decreased risk to oral cancer.
|
28595731 |
2017 |
|
rs243865
|
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The MMP-2 C1306T (rs243865) promoter polymorphism dominant model (CC v/s CT + CT + TT) revealed that the CC genotype had a 4.33-fold significant increased risk for development of cervical cancer (OR = 4.33; 95 % CI = 2.36-4.02, p = 0.0001) compared to those with variant genotypes (-1306 CT + TT).
|
26561467 |
2016 |
|
rs243865
|
|
Cervix carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results showed that the MMP2 rs24</span>3865 and MMP7 rs11568818 genotypes e were associated with increased susceptibility and development of cervical cancer in Chinese Han population.
|
26526578 |
2016 |
|
rs243865
|
|
cervical cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results showed that the MMP2 rs24</span>3865 and MMP7 rs11568818 genotypes e were associated with increased susceptibility and development of cervical cancer in Chinese Han population.
|
26526578 |
2016 |