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rs1217691063
|
|
Abnormal behavior
|
|
0.030 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphism 677C>T has been shown to be a risk factor for psychiatric disorders.
|
16545905 |
2006 |
|
rs1217691063
|
|
Abnormal behavior
|
|
0.030 |
GeneticVariation
|
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) gene variant C677T is suspected to be a risk factor for psychiatric disorders, but it remains uncertain whether the MTHFR C677T variant is associated with bipolar disorders.
|
18983889 |
2009 |
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rs1217691063
|
|
Abnormal behavior
|
|
0.030 |
GeneticVariation
|
BEFREE |
MTHFR C677T was significantly associated with all of the combined psychiatric disorders (SZ, BPD and UDD); random effects odds ratio (OR)=1.26 for TT versus CC genotype carriers; confidence interval (CI) 1.09-1.46); meta-regression did not suggest moderating effects of psychiatric diagnosis, sex, ethnic group or year of publication.
|
21185933 |
2011 |
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rs1217691063
|
|
Acquired thrombophilia
|
|
0.020 |
GeneticVariation
|
BEFREE |
A total of 808 white patients who developed preeclampsia (cases) and 808 women with previous uneventful pregnancies (controls) matched for age and parity were evaluated for inherited and acquired thrombophilia (factor V Leiden; factor II G20210A; methylenetetrahydrofolate reductase C677T; protein S, protein C, and antithrombin III deficiency; anticardiolipin antibodies; lupus anticoagulant; and hyperhomocysteinemia).
|
16246971 |
2005 |
|
rs1217691063
|
|
Acquired thrombophilia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Fasting total homocysteine (tHcy) and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation were evaluated in 91 patients with venous thromboembolism and without acquired thrombophilia, and in 91 age-matched and sex-matched controls.
|
11943942 |
2002 |
|
rs1217691063
|
|
Acrocyanosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The risk of acrocyanosis was significantly higher in patients homozygous for the mutation c.677C>T compared to those with no mutation (OR = 4.8 (95%CI 1.5-14.9)).
|
23816603 |
2015 |
|
rs1217691063
|
|
Acromegaly
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the influence of MTHFR C677T polymorphism, folate status and other lifestyle, nutritional and disease-specific variables on CRT risk in acromegaly.
|
23807201 |
2014 |
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rs1217691063
|
|
Activated Protein C Resistance
|
|
0.060 |
GeneticVariation
|
BEFREE |
We detected methylenetetrahydrofolate reductase (MTHFR) A1298C, MTHFR C677T, factor V Leiden, PAI-1, mutant prothrombin G20210A, plasma homocysteine, antithrombin III, protein S and activated protein C resistance.
|
20868443 |
2010 |
|
rs1217691063
|
|
Activated Protein C Resistance
|
|
0.060 |
GeneticVariation
|
BEFREE |
The difference of homocysteine, folate, vitamin B12, antithrombin III activity, protein C activity, free protein S activity, and activated protein C resistance were not statistically significant; and the number of subjects with MTHFR C677T, prothrombin G20210A, and factor V Leiden mutations were similar between the study groups.
|
25264994 |
2016 |
|
rs1217691063
|
|
Activated Protein C Resistance
|
|
0.060 |
GeneticVariation
|
BEFREE |
In addition, abnormal activated protein C resistance (or Factor V Leiden), Factor II G20219A variant, and the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR C677T) need to be considered.
|
19432826 |
2009 |
|
rs1217691063
|
|
Activated Protein C Resistance
|
|
0.060 |
GeneticVariation
|
BEFREE |
The pooled OR (and 95% CI) were: protein C deficiency, 6.49 (2.96 to 14.27); protein S deficiency, 1.14 (0.34 to 3.80); AT deficiency, 1.02 (0.28 to 3.67); APCr, 1.34 (0.16 to 11.52); FV1691 GA, 1.22 (0.80 to 1.87); PT20210GA, 1.10 (0.51 to 2.34); MTHFR C677T, 1.70 (1.23 to 2.34); and total plasma homocysteine >95th centile, 1.36 (0.53 to 3.51).
|
15781933 |
2005 |
|
rs1217691063
|
|
Activated Protein C Resistance
|
|
0.060 |
GeneticVariation
|
BEFREE |
Fasting total homocysteine, protein C (PC), protein S (PS), antithrombin (AT), activated protein C resistance (APCR) and lupus anticoagulant (LA) were assessed.MTHFR C677T mutation was determined.
|
19940469 |
2010 |
|
rs1217691063
|
|
Activated Protein C Resistance
|
|
0.060 |
GeneticVariation
|
BEFREE |
Determinations in blood samples of homocysteine concentrations; the occurrence of 677 C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene; protein C activities; activated protein C resistance ratios; concentrations of free protein S antigen; antithrombin III activities; and the occurrence of factor V Leiden mutation.
|
10847236 |
2000 |
|
rs1217691063
|
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
On multivariate logistic regression analysis, presence of a T allele in MTHFR C677T was found to be independently associated with higher circulating Hcy (odds ratio [OR] = 1.06, 95% confidence interval [CI]: 1.01-1.12, P = .024), and higher Gensini scores (OR: 1.01, 95% CI: 1.00-1.02, P = .046).MTHFR C677T TT polymorphism was associated with higher Hcy levels and more severe coronary lesions in patients with ACS.
|
29245302 |
2017 |
|
rs1217691063
|
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Plaque image characteristics, hyperhomocysteinemia, and gene polymorphism of homocysteine metabolism-related enzyme (MTHFR C677T) in acute coronary syndrome.
|
23314883 |
2013 |
|
rs1217691063
|
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome.
|
29245302 |
2017 |
|
rs1217691063
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recipient MTHFR polymorphisms (C677T) were associated with acute GvHD (P=0.03), and recipient VDR TaqI with TRM and overall survival (P=0.006 and P=0.04, respectively).Genetic factors that interfere with drug metabolisms are associated with treatment-related toxicities, GvHD and survival after HLA-identical HSCT in patients with leukemia and should be investigated prospectively.
|
19005482 |
2009 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism.
|
22706675 |
2012 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
We retrospectively analyzed the incidence of MTHFR C677T and the influence of genotype on methotrexate (MTX) toxicity in patients with acute leukemia undergoing maintenance chemotherapy.
|
12453860 |
2002 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
MTHFR gene polymorphisms, the c. 677C>T and c. 1298A>C have been implicated as risk factors for several types of cancers as the acute leukemia.
|
28374953 |
2018 |
|
rs1217691063
|
|
Acute leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C polymorphisms are not significant risk factors in adult acute leukemia in the Korean population.
|
17970089 |
2007 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population.
|
24476575 |
2014 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children.
|
21495160 |
2012 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant difference was detected between responder and non-responders according to MTHFR T677C polymorphism, but the patients who had TT genotype respond 1.75-fold worse than CC (OR, 0.57; 95% CI, 0.07-4.64) in ALL patients (p=0.59), and in DLBCL, CT genotype revealed a 1.8-fold worse response than CC genotype (OR, 0.54; 95% CI, 0.17-1.7), but TT genotype revealed 2.6-fold better response rates than patients with CC genotype (OR, 2.6; 95% CI, 0.26-26.8).
|
16944145 |
2006 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |