|
rs1217691063
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no difference in the distribution of the <i>MTHFR</i> 677C>T polymorphism between individuals with NW and overweight/obesity; neither when they were divided by overweight vs NW, nor when we contrasted obese vs NW.
|
31496910 |
2019 |
|
rs1217691063
|
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Elevated Hcy levels in the presence of the T allele in the C677T gene and of the A allele in the A1298C gene are associated with AMI and massive and submassive PE.
|
29916259 |
2019 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, it has been shown in patients with breast cancer a risk of presenting with an aggressive biophenotype about twice or three times higher in the presence of the C677T and A1298C polymorphisms, respectively.
|
31523170 |
2019 |
|
rs1217691063
|
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Comprehensive analysis of Methylenetetrahydrofolate reductase C677T in younger acute lymphoblastic leukemia patients: A single-center experience.
|
30545275 |
2019 |
|
rs1217691063
|
|
Impaired cognition
|
|
0.100 |
GeneticVariation
|
BEFREE |
Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer's disease.
|
30288696 |
2019 |
|
rs1217691063
|
|
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thrombophilic profile (factor V G1691A (Leiden), factor V H1299R (R2), prothrombin G20210A, MTHFR C677T, MTHFR A1298C, factor XIII V34L, β-fibrinogen-455 G-A and plasminogen activator inhibitor (PAI)-1 4G/5G) was evaluated using the cardiovascular diseases (CVD) StripAssay based on DNA isolation, PCR and reverse hybridisation.
|
31300468 |
2019 |
|
rs1217691063
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Via MTHFR C677T polymorphism, the findings in the present study demonstrated that there exists evidence on causal link between Hcy concentration and the risk of hypertension.
|
31769183 |
2019 |
|
rs1217691063
|
|
Parkinson Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We discovered the existence of no substantial link between the C677T and A1298C polymorphism and PD risk in any genetic framework comparisons.
|
31428686 |
2019 |
|
rs1217691063
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicated that, for Latinos, the C677T polymorphism is associated with a significant risk for developing breast cancer, whereas the A1289C polymorphism does not.
|
30877449 |
2019 |
|
rs1217691063
|
|
cervical cancer
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis.
|
31554347 |
2019 |
|
rs1217691063
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes.
|
30397262 |
2019 |
|
rs1217691063
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL.
|
30545275 |
2019 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
He was found as having MTHFR C677T homozygote and plasminogen activator inhibitor-1 4G/5G heterozygote gene mutation with high homocysteine level of 22.90 µmol/L, and he was diagnosed as hyperhomocysteinemia.
|
31409160 |
2019 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While C677T is known to play major roles in the risk of adult schizophrenia, our finding for the first time suggests an age-specific association between MTHFR polymorphisms and schizophrenia.
|
31302825 |
2019 |
|
rs1217691063
|
|
Myeloid Leukemia, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate Reductase Gene C677T and A1298C Polymorphic Sequence Variations Influences the Susceptibility to Chronic Myeloid Leukemia in Kashmiri Population.
|
31396477 |
2019 |
|
rs1217691063
|
|
Malignant tumor of cervix
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism was not associated with cervical cancer and HPV infection.
|
31170928 |
2019 |
|
rs1217691063
|
|
Migraine Disorders
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expert opinion: Determination of MTHFR C677T polymorphisms as well as measurement of homocysteine concentrations may be useful to migraine patients, particularly those suffering from migraine with aura.
|
30451038 |
2019 |
|
rs1217691063
|
|
Deep Vein Thrombosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis.
|
30303041 |
2019 |
|
rs1217691063
|
|
Cervix carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism was not associated with cervical cancer and HPV infection.
|
31170928 |
2019 |
|
rs1217691063
|
|
Myeloid Leukemia, Chronic
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos.
|
31188929 |
2019 |
|
rs1217691063
|
|
Squamous cell carcinoma of esophagus
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T genotype and serum vitamin B<sub>2</sub> or B<sub>12</sub> levels may interact in ways which associated with the EPL and ESCC risks.
|
31754346 |
2019 |
|
rs1217691063
|
|
Diabetic Nephropathy
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we first adopted methylenetetrahytrofolate reductase (MTHFR) gene C677T polymorphism as an instrument to infer the possible causal relevance between circulating homocysteine and DKD risk in a Chinese population and next attempted to build a risk prediction model for DKD.
|
30729677 |
2019 |
|
rs1217691063
|
|
Thrombophilia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The laboratory tests revealed high D-dimers, and positive IgG anti-cardiolipin and anti-beta2 glycoproteins I antibodies, whereas the genetic profile for thrombophilia revealed heterozygote mutation in MTHFR C677T and A1298C genes.
|
31725629 |
2019 |
|
rs1217691063
|
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |