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rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL).
|
20374270 |
2010 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Based on several studies, it is plausible that polymorphisms in the MTHFR gene, 677C>T and 1298A>C, are associated with a decreased susceptibility to childhood ALL in non-Asian populations.
|
19775302 |
2010 |
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rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated a possible association of MTHFR polymorphisms (677C>T and 1298A>C) and increased risk for acute lymphoblastic leukemia in 78 affected children.
|
20445408 |
2010 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL).
|
22943282 |
2012 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility.
|
28062297 |
2017 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the adult subgroup, there was no significant association between the C677T variant and ALL risk (Dominant model: OR(RE)=0.88, 95% CI: 0.45-1.72, p=0.72).
|
23061880 |
2012 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seventy-two children with ALL and 109 age- and sex-matched healthy children from Western Iran were screened for MTHFR C677T and A1298C variants by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
|
22017305 |
2012 |
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rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models.
|
31188929 |
2019 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this case-control study was to evaluate the association of the C677T MTHFR gene polymorphism with acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myeloid leukaemia (CML) and chronic lymphocytic leukaemia (CLL).
|
22441130 |
2012 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors describe the case of a 12-year-old male with acute lymphoblastic leukemia and a homozygous methylenetetrahydrofolate reductase C677T mutation, who developed subacute methotrexate-induced toxicity and cerebral venous thrombosis after receiving intrathecal methotrexate.
|
20121554 |
2010 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians.
|
24377532 |
2013 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two polymorphisms of the gene encoding MTHFR, C677T and A1298C, alter MTHFR enzyme activity and may be associated with ALL relapse.
|
24637499 |
2014 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings support the proposal that the common genetic C677T polymorphism in the MTHFR contributes to the risk of adult ALL, but not to the childhood ALL susceptibility.
|
17035405 |
2006 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms.
|
24237708 |
2014 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Associations found in these studies were significant with respect to gender bias; hence, it is possible that MTHFR C677T and A1298C can be good markers for ALL.
|
16923565 |
2006 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene on MTX-induced toxicity during treatment of children with ALL.
|
26528799 |
2015 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy.
|
15003888 |
2004 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Accumulated evidence has demonstrated that C677T and A1298C polymorphisms of the MTHFR gene are associated with acute lymphoblastic leukemia (ALL) risk, but the results have been inconclusive.
|
21702646 |
2011 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia.
|
31499477 |
2019 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping of MTHFR polymorphism, C677T particularly, prior to treatment for ALL is likely to be useful with the aim of tailoring MTX therapy and thus reducing the MTX-related toxicities.
|
22528943 |
2012 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have analyzed the MTHFR C677T polymorphism in 52 patients and 88 control individuals, all ethnic Greek residents of northern Greece, and examined the association of this polymorphism with (a) susceptibility to childhood ALL and (b) the distribution of average plasma alanine aminotransferase (ALT) levels, white blood cell counts (WBC), and hemoglobin levels (Hb) during the induction and consolidation phases of treatment.
|
16123993 |
2006 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.
|
29911750 |
2018 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C to T transition (C677T) in the MTHFR gene is reported to reduce the risk for colorectal cancer and acute lymphocytic leukemia in homozygotes (TTs).
|
11408344 |
2001 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conducted a case-control study in 95 north Indian children with acute lymphoblastic leukemia (ALL) and 255 controls, to investigate the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of ALL.
|
20367562 |
2010 |