|
rs786205155
|
|
Acute lymphocytic leukemia
|
|
0.710 |
GeneticVariation
|
BEFREE |
Here we identify a novel germline ETV6 p. L349P mutation in a kindred affected by thrombocytopenia and ALL.
|
26102509 |
2015 |
|
rs786205155
|
|
Acute lymphocytic leukemia
|
C |
0.710 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs869312821
|
|
Acute lymphocytic leukemia
|
C |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs786205154
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs767454740
|
|
Acute lymphocytic leukemia
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs767215758
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs752746786
|
|
Acute lymphocytic leukemia
|
T |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs730881864
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs63750250
|
|
Acute lymphocytic leukemia
|
AT |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs587782545
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs587776834
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121913488
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121909646
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, 677T allele was linked to a decrease risk of ALL [odds ratio (OR), 0.43; 95% confidence interval (CI), 0.22-0.86], whereas the 1298A>C polymorphism presents an elevated risk factor [OR, 2.01; 95% CI, 1.01-3.99] in non-White children.
|
16182363 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We retrospectively evaluated the association of the MTHFR 677C>T and 1298A>C polymorphisms with pediatric ALL by genotyping a study sample of 443 ALL patients consecutively enrolled onto the German multicenter trial ALL-BFM 2000 and 379 healthy controls.
|
15921520 |
2005 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn.
|
25342508 |
2014 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL.
|
25115513 |
2015 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014).
|
29390492 |
2017 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.
|
11736945 |
2001 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results.
|
22094326 |
2012 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A meta-analysis of case-control studies that investigated the association between the C677T and/or A1298C polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and acute lymphoblastic leukemia (ALL) was carried out.
|
16897583 |
2006 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated a possible association of MTHFR polymorphisms (677C>T and 1298A>C) and increased risk for acute lymphoblastic leukemia in 78 affected children.
|
20445408 |
2010 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant relation was found between MTHFR A1298C polymorphism and the risks of therapy induced complications or relapse rate in the studied ALL patients.
|
19923983 |
2010 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
It has been suggested that two MTHFR polymorphisms, 677C>T and 1298A>C, influence risk of acute lymphoblastic leukemia (ALL).
|
20374270 |
2010 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seventy-two children with ALL and 109 age- and sex-matched healthy children from Western Iran were screened for MTHFR C677T and A1298C variants by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
|
22017305 |
2012 |