|
rs786205155
|
|
Acute lymphocytic leukemia
|
C |
0.710 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs869312821
|
|
Acute lymphocytic leukemia
|
C |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs786205154
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs767454740
|
|
Acute lymphocytic leukemia
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs767215758
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs752746786
|
|
Acute lymphocytic leukemia
|
T |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs730881864
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs63750250
|
|
Acute lymphocytic leukemia
|
AT |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs587782545
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs587776834
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121913488
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs121909646
|
|
Acute lymphocytic leukemia
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs899127658
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study was designed to prospectively evaluate the role of the TT677 methylenetetrahydrofolate reductase (MTHFR) genotype, the prothrombin G20210A mutation, the factor V G1691A mutation, deficiencies of protein C, protein S, antithrombin, and increased lipoprotein (a) concentrations in leukemic children treated according to the ALL-Berlin-Frankfurt-Muenster (BFM) 90/95 study protocols with respect to the onset of vascular events.
|
10029588 |
1999 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.
|
11736945 |
2001 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.
|
11736945 |
2001 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C to T transition (C677T) in the MTHFR gene is reported to reduce the risk for colorectal cancer and acute lymphocytic leukemia in homozygotes (TTs).
|
11408344 |
2001 |
|
rs57725551
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs569954362
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
A high-abundance C/T696 polymorphism was detected with nearly identical frequencies for both alleles, and a heterozygous C/A1242 sequence variant was identified in two ALL specimens.
|
11705857 |
2001 |
|
rs1800562
|
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Contrary to some expectations, however, the frequency of the C282Y allele in acute lymphoblastic leukemia turned out to be normal (7.0%, n=43).
|
11836162 |
2002 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study we describe the genotyping of the MTHFR C677T polymorphism by melting curve analysis with the LightCycler in a case-controlled study of patients with acute lymphocytic leukemia (ALL), myelogenous leukemia (AML), and chronic myelogenous leukemia (CML), and assess the effect of this common polymorphism on the leukemia risk in adult patients in Turkey.
|
15068389 |
2003 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
rs762613037
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, 2/126 with AML (1.6%), 2/57 with CML (5.1%), and 2/91 with ALL (2.1%) were heterozygous 4349G/A.No patients were homozygous 4349A.
|
12693719 |
2003 |
|
rs397507444
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy.
|
15003888 |
2004 |
|
rs1217691063
|
|
Acute lymphocytic leukemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy.
|
15003888 |
2004 |
|
rs72481843
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Towards this aim we analyzed the CYP3A4-290A/G substitution and three NR3C1 polymorphisms (200G/A, 1220A/G and BclI RFLP) in 222 children with acute lymphoblastic leukemia (ALL) whose treatment protocols, among other components, contained corticosteroid drugs.
|
15462611 |
2004 |