|
rs10106
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
These findings suggested that common genetic polymorphisms in the FPGS coding region including rs7039789, rs1544105, and rs10106 are significantly associated with increased ALL risk in Thai children.
|
26107232 |
2015 |
|
rs10235796
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IKZF1 SNPs, rs10235796 and rs6964969, and the CDKN2A SNP rs3731246 (previously unreported) could serve as risk markers for ALL susceptibility in Yemeni children.
|
28768142 |
2017 |
|
rs10272724
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children.
|
30806315 |
2019 |
|
rs1039659576
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
For the first time, we associate the RFC1 80G>A and NNMT IVS -151C>T variants to an increased ALL susceptibility.
|
19020309 |
2009 |
|
rs1039659576
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Children with ALL (n = 96) were screened for GCPII C1561T, RFC1 G80A, cSHMT C1420T, TYMS 5´-UTR 2R3R, TYMS 3´-UTR ins6/del6, MTHFR C677T, MTR A2756G polymorphisms using PCR-RFLP and PCR-amplified fragment length polymorphism techniques.
|
22838948 |
2012 |
|
rs1042522
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML.
|
27053289 |
2016 |
|
rs1042522
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis regulation and tumor suppression.
|
23653000 |
2013 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests there was no association between MDR1 C3435T polymorphism and children ALL risk in overall populations, but significant association with an increased risk in Asians.
|
25661341 |
2015 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy individuals.
|
19317599 |
2008 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
In terms of infection incidence, polymorphism C3435T may contribute to potential life-threatening infections during paediatric ALL therapy, through glucocorticoid usage.
|
30508724 |
2019 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
There were no association in distribution of genotypes of MDR-1 C3435T polymorphism and the risk of ALL.
|
23244145 |
2012 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
To investigate their possible roles in disease susceptibility and some disease characteristics we genotyped C3435T and G2677T/A polymorphisms in multidrug resistance-1 (MDR1) gene with a single base extension method and the G34A and C421A polymorphisms of the breast cancer resistance protein gene with an allelic discrimination system in 396 children with acute lymphoblastic leukaemia (ALL) and 192 control patients.
|
18243305 |
2008 |
|
rs1045642
|
|
Acute lymphocytic leukemia
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, we do not have reason to assume that the C3435T SNP contributes to drug resistance of ALL and prognosis of ALL patients.
|
12851703 |
2003 |
|
rs104893636
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The p.Glu81Val mutation of HOXD4 thus results in a partial loss-of-function, which might be involved in childhood ALL.
|
15776434 |
2005 |
|
rs1051296
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotyping for SLC19A1 rs1051296 G>T in 131 children with ALL was performed using the Sequenom MassArray system.
|
24927955 |
2014 |
|
rs10519612
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a higher risk of developing ALL for rs10519612 CC, rs17007695 TC and rs17007695 CC genotype carriers.
|
24689757 |
2015 |
|
rs1057519695
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia.
|
27145535 |
2016 |
|
rs1057519743
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
|
rs1057519753
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This mutation was identical to the JAK1 V658F mutation previously found in human APL and acute lymphoblastic leukemia samples.
|
21436584 |
2011 |
|
rs1057519773
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
At the first relapse, an examination of the bone marrow revealed a transformation into acute lymphoblastic leukemia and an F317L mutation in BCR-ABL1 gene, which responded preferentially to nilotinib over dasatinib.
|
24532437 |
2014 |
|
rs1057519834
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Early T-Cell Precursor Acute Lymphoblastic Leukemia in an Infant With an NRAS Q61R Mutation and Clinical Features of Juvenile Myelomonocytic Leukemia.
|
27145535 |
2016 |
|
rs1057519866
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here, we present kinetic and structural properties of cN-II variants that represent 75 % of mutated alleles in patients who experience relapsed ALL (R367Q, R238W and L375F).
|
27756303 |
2016 |
|
rs1057519866
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Here we use a conditional-and-inducible leukaemia model to demonstrate that expression of NT5C2(R367Q), a highly prevalent relapsed-ALL NT5C2 mutation, induces resistance to chemotherapy with 6-mercaptopurine at the cost of impaired leukaemia cell growth and leukaemia-initiating cell activity.
|
29342136 |
2018 |
|
rs10740055
|
|
Acute lymphocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the recessive models revealed that six SNPs were risk factors for acute lymphoblastic leukemia: rs10740055, rs7089424, rs10994982, rs7896246, rs10821938, and rs7923074.
|
28381164 |
2017 |
|
rs10821936
|
|
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SNPs (IKZF1 rs11978267, ARID5B rs10821936 and rs10994982, CEBPE rs2239633) were genotyped in 265 cases [169 acute lymphoblastic leukemia (ALL) and 96 acute myeloid leukaemia (AML)] and 505 controls by Taqman allelic discrimination assay.
|
24564228 |
2014 |