|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies such as those on APC I1307K and CHEK2 1100delC may suggest the way forward for the identification of 'breast-colon cancer' genes.
|
14574178 |
2001 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K sequence variant was not found in 67 patients with esophageal cancer, 53 patients with gastric carcinoma (13 MSI-H and 44 MSI-negative), or ten patients with sporadic MSI-H colon cancer.
|
10445854 |
1999 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significantly, of the 12 individuals who possessed the I1307K mutation, none was diagnosed with colorectal cancer and none had a known first-, second-, or third-degree relative diagnosed with colon cancer.
|
9407954 |
1997 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K polymorphism, therefore, exists in all ethnic Jewish populations: Ashkenazi and non-Ashkenazi, with or without colon cancer.
|
11551102 |
2001 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon cancer in Ashkenazi breast-ovarian cancer families, and a role of mismatch repair deficiency was suggested.
|
9869603 |
1999 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia.
|
15507235 |
2004 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers.
|
12822869 |
2003 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have shown that the family's phenotype does not result from APC mutations (including the I1307K variant) or from genetic changes in the other known genes that predispose to colon cancer.
|
10092300 |
1999 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation.
|
10756345 |
2000 |
|
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K variant was analyzed in 242 eligible respondents who were selected because they had a personal or family history of colon cancer.
|
11159880 |
2001 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K variant was analyzed in 242 eligible respondents who were selected because they had a personal or family history of colon cancer.
|
11159880 |
2001 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significantly, of the 12 individuals who possessed the I1307K mutation, none was diagnosed with colorectal cancer and none had a known first-, second-, or third-degree relative diagnosed with colon cancer.
|
9407954 |
1997 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation.
|
10756345 |
2000 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia.
|
15507235 |
2004 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K sequence variant was not found in 67 patients with esophageal cancer, 53 patients with gastric carcinoma (13 MSI-H and 44 MSI-negative), or ten patients with sporadic MSI-H colon cancer.
|
10445854 |
1999 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers.
|
12822869 |
2003 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon cancer in Ashkenazi breast-ovarian cancer families, and a role of mismatch repair deficiency was suggested.
|
9869603 |
1999 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K polymorphism, therefore, exists in all ethnic Jewish populations: Ashkenazi and non-Ashkenazi, with or without colon cancer.
|
11551102 |
2001 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have shown that the family's phenotype does not result from APC mutations (including the I1307K variant) or from genetic changes in the other known genes that predispose to colon cancer.
|
10092300 |
1999 |
|
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies such as those on APC I1307K and CHEK2 1100delC may suggest the way forward for the identification of 'breast-colon cancer' genes.
|
14574178 |
2001 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
|
22281684 |
2012 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Immunohistochemistry with Anti-BRAF V600E (VE1) Mouse Monoclonal Antibody is a Sensitive Method for Detection of the BRAF V600E Mutation in Colon Cancer: Evaluation of 120 Cases with and without KRAS Mutation and Literature Review.
|
29127628 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A colon cancer cell line with RNF43-G659Vfs*41 and BRAF-V600E mutations was sensitive to activation of Wnt/β-catenin signaling.
|
31811196 |
2019 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, our findings suggest that targeting ErbB-3 receptors could represent an effective therapeutic approach in BRAF-V600E mutant colon cancer.
|
26160848 |
2015 |
|
rs121913377
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Herein, we present the case of a patient with bulky V600E-mutant BRAF hepatic flexure colon carcinoma, treated initially with FOLFOX plus bevacizumab neoadjuvant therapy and surgery.
|
23792567 |
2013 |