rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significantly, of the 12 individuals who possessed the I1307K mutation, none was diagnosed with colorectal cancer and none had a known first-, second-, or third-degree relative diagnosed with colon cancer.
|
9407954 |
1997 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significantly, of the 12 individuals who possessed the I1307K mutation, none was diagnosed with colorectal cancer and none had a known first-, second-, or third-degree relative diagnosed with colon cancer.
|
9407954 |
1997 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K sequence variant was not found in 67 patients with esophageal cancer, 53 patients with gastric carcinoma (13 MSI-H and 44 MSI-negative), or ten patients with sporadic MSI-H colon cancer.
|
10445854 |
1999 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon cancer in Ashkenazi breast-ovarian cancer families, and a role of mismatch repair deficiency was suggested.
|
9869603 |
1999 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have shown that the family's phenotype does not result from APC mutations (including the I1307K variant) or from genetic changes in the other known genes that predispose to colon cancer.
|
10092300 |
1999 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K sequence variant was not found in 67 patients with esophageal cancer, 53 patients with gastric carcinoma (13 MSI-H and 44 MSI-negative), or ten patients with sporadic MSI-H colon cancer.
|
10445854 |
1999 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a second study indicated that the I1307K mutation did not contribute greatly to the risk of colon cancer in Ashkenazi breast-ovarian cancer families, and a role of mismatch repair deficiency was suggested.
|
9869603 |
1999 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have shown that the family's phenotype does not result from APC mutations (including the I1307K variant) or from genetic changes in the other known genes that predispose to colon cancer.
|
10092300 |
1999 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation.
|
10756345 |
2000 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation.
|
10756345 |
2000 |
rs121913314
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A recent report suggested that the risk of colon cancer is higher for those who carry a C-->T transition mutation on codon 531 (Gln-531-->Amber-531) of src gene.
|
10704743 |
2000 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies such as those on APC I1307K and CHEK2 1100delC may suggest the way forward for the identification of 'breast-colon cancer' genes.
|
14574178 |
2001 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K polymorphism, therefore, exists in all ethnic Jewish populations: Ashkenazi and non-Ashkenazi, with or without colon cancer.
|
11551102 |
2001 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K variant was analyzed in 242 eligible respondents who were selected because they had a personal or family history of colon cancer.
|
11159880 |
2001 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K variant was analyzed in 242 eligible respondents who were selected because they had a personal or family history of colon cancer.
|
11159880 |
2001 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The I1307K polymorphism, therefore, exists in all ethnic Jewish populations: Ashkenazi and non-Ashkenazi, with or without colon cancer.
|
11551102 |
2001 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies such as those on APC I1307K and CHEK2 1100delC may suggest the way forward for the identification of 'breast-colon cancer' genes.
|
14574178 |
2001 |
rs4994
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis of a subgroup with a higher body mass index showed that the Trp64Arg variant increased the OR (2.63; 95% confidence interval, 1.13-6.11) for colon cancer, but not for rectal cancer, compared with the Trp64 genotype.
|
11706779 |
2001 |
rs459552
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used data collected as part of a multicenter study of 1,585 incident cases of colon cancer and 1,945 age- and sex-matched population-based controls to evaluate genetic, dietary, and environmental associations with the D1822V [corrected] variant of the APC gene.
|
11221825 |
2001 |
rs35187787
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the fact that this alteration (Ala592Thr) segregated with colon cancer and diffuse gastric cancer in one big family, suggests that this E-cadherin missense alteration, beside predisposing to diffuse gastric cancer, also may play a role in colorectal carcinogenesis.
|
11562785 |
2001 |
rs1205454520
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We now show that stable expression of oncogenic Ki-ras(G12V) c</span>onverts the HD6-4 colon cancer cell line from insensitive to TGF-beta1 to growth-promoted by TGF-beta1.
|
11029459 |
2001 |
rs1017621656
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We now show that stable expression of oncogenic Ki-ras(G12V) c</span>onverts the HD6-4 colon cancer cell line from insensitive to TGF-beta1 to growth-promoted by TGF-beta1.
|
11029459 |
2001 |
rs1801155
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers.
|
12822869 |
2003 |
rs1463038513
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers.
|
12822869 |
2003 |
rs1217691063
|
|
Colon Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and risk of proximal colon cancer in north Italy.
|
12576444 |
2003 |