|
rs1017621656
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We now show that stable expression of oncogenic Ki-ras(G12V) c</span>onverts the HD6-4 colon cancer cell line from insensitive to TGF-beta1 to growth-promoted by TGF-beta1.
|
11029459 |
2001 |
|
rs10222633
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1039659576
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither MTR D919G nor RFC 80G>A polymorphisms were associated with altered colon cancer risk.
|
16284371 |
2005 |
|
rs10411210
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs1042522
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs1042636
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96).
|
28765616 |
2017 |
|
rs1044129
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among seven target variants, rs1044129 at the miR-367 binding site of calcium channel ryanodine receptor gene 3 (RYR3) was associated with relapse-free survival (RFS) for colon cancer patients as a recessive model in a univariate analysis.
|
23393343 |
2013 |
|
rs10450310
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four SNPs in the 3'-untranslated region (UTR) of the gene (rs10082466, rs2120132, rs2099902, and rs10450310) were associated with an increased risk of colon cancer in African Americans.
|
22282660 |
2012 |
|
rs1045485
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs1051753269
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Through biochemical and cellular pharmacologic studies, we have determined that cells harboring the colon cancer-derived G719S and G724S mutants are responsive to cetuximab therapy in vitro and found that the requirement for asymmetric dimerization of these mutant EGFR to promote cellular transformation may explain their greater inhibition by cetuximab than small-molecule kinase inhibitors.
|
24894453 |
2014 |
|
rs1057519725
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, we characterized KRAS A146V biologically using colon cancer cells.
|
30448735 |
2019 |
|
rs1057519822
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.
|
31227518 |
2019 |
|
rs1060503118
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
From the Colon Cancer Family Registry, we identified 10 carriers who had both a MUTYH mutation (6 with c.1187G>A p.(Gly396Asp), 3 with c.821G>A p.(Arg274Gln), and 1 with c.536A>G p.(Tyr179Cys)) and a MMR gene mutation (3 in MLH1, 6 in MSH2, and 1 in PMS2), 375 carriers of a single (monoallelic) MUTYH mutation alone, and 469 carriers of a MMR gene mutation alone.
|
26202870 |
2015 |
|
rs10741657
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we investigated the association of three functional gene variants in GC (rs2282679 T>G), DHCR7 (rs12785878 G>T) and CYP2R1 (rs10741657 A>G) with time to recurrence (TTR) in patients with stages II and III colon cancer.
|
23793229 |
2013 |
|
rs10759932
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |
|
rs10958713
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three IκBKβ SNPs were associated with a statistically significant lower colorectal or colon cancer risk: rs9694958 (A>G intron 5) (colorectal: OR(hzv) = 0.26(0.07-0.99), P(trend) = 0.048, P(adj) = 0.25), rs10958713 (A>C intron 19) (colon: OR(hzv) = 0.62(0.42-0.92), P(trend) = 0.005, P(adj) = 0.03) and rs5029748 (C>A intron 2) (colon: OR(het) = 0.72(0.56-0.91), P(trend) = 0.01, P(adj) = 0.08).
|
23002237 |
2013 |
|
rs1130409
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the MUTYH Gln324His and the APEX1 Asp148Glu constitutes an increased risk of colorectal cancer, especially colon cancer.
|
18823566 |
2008 |
|
rs1131691014
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
PIA identified SNPs that may interact with the GSTT1 polymorphism, including coding polymorphisms in TP53 (Arg72Pro in p53) and CASP8 (Asp302His in caspase 8), which may modify the association between this polymorphism and colon cancer.
|
16217767 |
2006 |
|
rs1131691029
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was a significant interaction between the -200A>C IGFBP3 polymorphism and the Pro12Ala PPARgamma polymorphism and risk of colon cancer (p for interaction = 0.02) with individuals being at significantly lower risk if they had both the CC IGFBP3 genotype and the PA/AA PPARgamma genotype.
|
16489531 |
2006 |
|
rs1136410
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed that the PARP Val762Ala SNP modified the association between marine n-3 PUFA and rectal cancer risk, with no evidence of interaction among colon cancer (heterogeneity test p=0.003).
|
20559012 |
2009 |
|
rs11536898
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs11721827 was associated with rectal cancer (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.02, 1.58 for AC/CC vs. AA genotype, Wald p = 0.035; adjusted p = 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68, 95% CI 0.49, 0.95 for GG vs. CC/CG and OR 0.50.
|
21792899 |
2012 |
|
rs11539752
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest that GZMB Q55R, P94A, and Y247H polymorphisms are not significantly associated with colon cancer incidence, or metastasis to lymph node and distant organ.
|
25313744 |
2015 |
|
rs11615
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In women, the rs11615 CC genotype worsened TTN (co-dominant model p = 0.008, recessive model p = 0.003) and rs13181 G allele improved the TTG (p = 0.039).
|
31395900 |
2019 |
|
rs11625206
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
MAP2K1 rs8039880 [odds ratio (OR) = 0.57, 95% confidence interval (CI) = 0.38, 0.83; GG versus AA genotype] and MAP3K9 rs11625206 (OR = 1.41, 95% CI = 1.14, 1.76; recessive model) were associated with colon cancer (P (adj) value < 0.05).
|
23027623 |
2012 |
|
rs11721827
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 rs11721827 was associated with rectal cancer (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.02, 1.58 for AC/CC vs. AA genotype, Wald p = 0.035; adjusted p = 0.126); TLR3 rs3775292 and TLR4 rs11536898 were associated with colon cancer (OR 0.68, 95% CI 0.49, 0.95 for GG vs. CC/CG and OR 0.50.
|
21792899 |
2012 |