|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While MTHFR C677T and A1298C polymorphisms were not previously studied in an Arab population with respect to the susceptibility for developing schizophrenia, the MTRR A66G was not previously investigated in any population around the world.
|
22813657 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this study found no support that maternal/child MTHFR C677T genotype and maternal folate intake during pregnancy contribute to common aetiological pathways that are shared between schizophrenia and non-clinical psychotic symptoms in adolescents, assuming that decreased folate-status increases schizophrenia risk.
|
20418067 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia.
|
25101272 |
2014 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T genotype contributes to certain executive function deficits in schizophrenia.
|
17344026 |
2007 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences.
|
22690662 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased risk, OR 1.48 (1.18-1.86).
|
15729744 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects.All subjects were of Dutch ancestry.
|
17716874 |
2008 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis showed that MTHFR C677T was significantly associated with SZ, the highest OR was found for the recessive model (for TT vs. CT + CC: OR = 1.34, 95% CI: 1.18-1.53); a marginal association of MTHFR C677T with increased risk of BPD has also been found for the recessive model (OR = 1.26, 95% CI: 1.00-1.59).
|
24938371 |
2015 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Transmission Disequilibrium Test (TDT) analysis showed no preferential transmission of the 677T allele from parents heterozygous for the MTHFR 677C > T polymorphism to schizophrenia offspring (P = 0.27).
|
17503473 |
2007 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group.
|
23586533 |
2014 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.
|
16172608 |
2006 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism may play a role as a modifying factor for age of onset in schizophrenia.
|
19746410 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (P<0.01), which was mainly driven by the male group.
|
16076517 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia.
|
29202425 |
2018 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
While C677T is known to play major roles in the risk of adult schizophrenia, our finding for the first time suggests an age-specific association between MTHFR polymorphisms and schizophrenia.
|
31302825 |
2019 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, neither the MTHFR C677T nor the A1298C polymorphisms are associated with schizophrenia in women.
|
16084002 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals.
|
21980405 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated a possible interaction between MTHFR 677C>T polymorphism and winter birth in the development of schizophrenia in a group of 742 schizophrenia patients and 884 control subjects.All subjects were of Dutch ancestry.
|
21093223 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T-allele of the C677T polymorphism has recently been associated with earlier age at onset of schizophrenia.
|
21302350 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, both elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia and are risk factors for schizophrenia.
|
19564051 |
2009 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Elevated Hcy levels and, in line with this finding, homozygosity for the 677C-->T mutation in the MTHFR gene were not associated with an increased risk for schizophrenia.
|
14572619 |
2003 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results do not support a role for the C677T MTHFR variant in schizophrenia.
|
16969279 |
2006 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a ris</span>k factor for schizophrenia</span>.
|
27025471 |
2016 |