|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma homocysteine and the methylenetetrahydrofolate reductase C677T gene variant: lack of association with schizophrenia.
|
10424670 |
1999 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association between the methylenetetrahydrofolate reductase 677C-->T missense mutation and schizophrenia.
|
10889537 |
2000 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Elevated Hcy levels and, in line with this finding, homozygosity for the 677C-->T mutation in the MTHFR gene were not associated with an increased risk for schizophrenia.
|
14572619 |
2003 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We carried out a meta-analysis of MTHFR C677T genotype and schizophrenia risk, and found that TT homozygotes had a significantly increased risk, OR 1.48 (1.18-1.86).
|
15729744 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (P<0.01), which was mainly driven by the male group.
|
16076517 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, neither the MTHFR C677T nor the A1298C polymorphisms are associated with schizophrenia in women.
|
16084002 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study was performed to quantify the risk of schizophrenia in the presence of elevated homocysteine concentrations or homozygosity for the 677C --> T polymorphism (677TT) in the methylenetetrahydrofolate reductase (MTHFR) gene in subjects of Dutch ancestry.
|
15806605 |
2005 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.
|
16172608 |
2006 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results do not support a role for the C677T MTHFR variant in schizophrenia.
|
16969279 |
2006 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the genotype and allelic frequencies of MTHFR 677C>T polymorphism in the group of patients with bipolar disorder type I (BDI) (n=200) and schizophrenia (n=200), and in the control group (n=300).
|
16545905 |
2006 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T genotype contributes to certain executive function deficits in schizophrenia.
|
17344026 |
2007 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Transmission Disequilibrium Test (TDT) analysis showed no preferential transmission of the 677T allele from parents heterozygous for the MTHFR 677C > T polymorphism to schizophrenia offspring (P = 0.27).
|
17503473 |
2007 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
For schizophrenia and MTHFR C677T, the fixed-effects odds ratio for TT versus CC was 1.44 (95% CI: 1.21, 1.70), with low heterogeneity (I(2) = 42%)--based on 2,762 cases and 3,363 controls.
|
17074966 |
2007 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects.All subjects were of Dutch ancestry.
|
17716874 |
2008 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia.
|
18165967 |
2008 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.
|
17976958 |
2008 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia.
|
18186041 |
2008 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, both elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia and are risk factors for schizophrenia.
|
19564051 |
2009 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, this study found no support that maternal/child MTHFR C677T genotype and maternal folate intake during pregnancy contribute to common aetiological pathways that are shared between schizophrenia and non-clinical psychotic symptoms in adolescents, assuming that decreased folate-status increases schizophrenia risk.
|
20418067 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism may play a role as a modifying factor for age of onset in schizophrenia.
|
19746410 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T polymorphism, are risk factors for schizophrenia.
|
19939410 |
2010 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals.
|
21980405 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated a possible interaction between MTHFR 677C>T polymorphism and winter birth in the development of schizophrenia in a group of 742 schizophrenia patients and 884 control subjects.All subjects were of Dutch ancestry.
|
21093223 |
2011 |
|
rs1217691063
|
|
Schizophrenia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T-allele of the C677T polymorphism has recently been associated with earlier age at onset of schizophrenia.
|
21302350 |
2011 |