|
rs1800797
|
|
Diabetic Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that IL-6 rs1800795, rs1800796 and rs1800797 played important roles in DN development while IL-6 rs2069837 and rs2069840 might not be related to DN.
|
31451183 |
2019 |
|
rs1800797
|
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor alleles of rs1800795 raised and rs1800797 reduced the risk of obesity, while rs1800796 and rs2069845 may not be associated.
|
31472475 |
2019 |
|
rs1800797
|
|
Stomach Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms.
|
30525242 |
2019 |
|
rs1800797
|
|
Malignant neoplasm of liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800797
|
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800797
|
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy.
|
29552316 |
2018 |
|
rs1800797
|
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800797
|
|
Trichohepatoenteric Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome.
|
28829905 |
2017 |
|
rs1800797
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of this, the current study aimed to investigate the possible association of 5' promoter polymorphisms G-597A (rs1800797), G-572C (rs1800796) and G-174C (rs1800795) with the risk of SLE.
|
28530463 |
2017 |
|
rs1800797
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of IL-6 rs1800796 G/G genotype, IL-6 rs1474358 C-allele, and IL-6 rs1800797 A-allele was more frequent in chronic HCV-infected patients than in HCC patients.
|
28340949 |
2017 |
|
rs1800797
|
|
Complete Trisomy 21 Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome.
|
28829905 |
2017 |
|
rs1800797
|
|
Down Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the frequency of interleukin 6 polymorphisms (rs1800795, rs1800796, and rs1800797) in individuals with DS and individuals without the syndrome.
|
28829905 |
2017 |
|
rs1800797
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of IL-6 rs1800796 G/G genotype, IL-6 rs1474358 C-allele, and IL-6 rs1800797 A-allele was more frequent in chronic HCV-infected patients than in HCC patients.
|
28340949 |
2017 |
|
rs1800797
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Rheumatic Heart Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The IL-6 promoter rs1800797 (-597G/A) SNP may influence susceptibility to RHD of people of Māori and Pacific ancestry living in NZ.
|
27400406 |
2016 |
|
rs1800797
|
|
Adult onset asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09-1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12-1.90).
|
26938664 |
2016 |
|
rs1800797
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our preliminary findings are suggestive of an association between rs1800797 and the risk of MDD.
|
27502736 |
2016 |
|
rs1800797
|
|
CATARACT, ANTERIOR POLAR
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CRP +1846C/T (rs1205), IL-6 -597G/A (rs1800797), and IL-10 -592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.
|
27705004 |
2016 |
|
rs1800797
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.
|
25774595 |
2015 |
|
rs1800797
|
|
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression.
|
25962811 |
2015 |
|
rs1800797
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes.
|
25222779 |
2014 |