|
rs1800797
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele.
|
19585495 |
2009 |
|
rs1800797
|
|
Allergic rhinitis (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
AA genotype in rs1800797 of IL-6 was associated with the increased risk of developing AR.
|
24974143 |
2014 |
|
rs1800797
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
|
Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800797
|
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation
|
BEFREE |
Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively).
|
17416766 |
2007 |
|
rs1800797
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Among postmenopausal women not recently exposed to hormones, the AG/GG genotypes of rs1800797 (-596A>G) and the GC/CC genotypes of rs1800795 (-174G>C) significantly reduced risk of breast cancer among non-Hispanic white women [odds ratio (OR), 0.69; 95% confidence interval (95% CI), 0.48-1.00 and OR, 0.68; 95% CI, 0.47-0.99, respectively] and Hispanic/Native American women (OR, 0.48; 95% CI, 0.28-0.83 and OR, 0.44; 95% CI, 0.26-0.99, respectively).
|
17416766 |
2007 |
|
rs1800797
|
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of IL-6 rs1800796 G/G genotype, IL-6 rs1474358 C-allele, and IL-6 rs1800797 A-allele was more frequent in chronic HCV-infected patients than in HCC patients.
|
28340949 |
2017 |
|
rs1800797
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of IL-6 rs1800796 G/G genotype, IL-6 rs1474358 C-allele, and IL-6 rs1800797 A-allele was more frequent in chronic HCV-infected patients than in HCC patients.
|
28340949 |
2017 |
|
rs1800797
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797</span> may be a tumor marker for cancer therapy.
|
29552316 |
2018 |
|
rs1800797
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797</span> may be a tumor marker for cancer therapy.
|
29552316 |
2018 |
|
rs1800797
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Considering these promising results, IL-6 promoter including rs1800795, rs1800796 and rs1800797 may be a tumor marker for cancer therapy.
|
29552316 |
2018 |
|
rs1800797
|
|
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression.
|
25962811 |
2015 |
|
rs1800797
|
|
Degenerative polyarthritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
For knee OA the smallest P-value was seen for rs1800797 OR(Aallele)=1.055 (95%CI 0.98-1.12) P<0.18, no significant heterogeneity was observed (I(2)=0%, P<0.68).
|
20175976 |
2010 |
|
rs1800797
|
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1800797 was also associated with lung cancer among never smokers in the GENEVA dataset.
|
26372664 |
2016 |
|
rs1800797
|
|
Adult onset asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09-1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12-1.90).
|
26938664 |
2016 |
|
rs1800797
|
|
Stomach Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms.
|
30525242 |
2019 |
|
rs1800797
|
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of this, the current study aimed to investigate the possible association of 5' promoter polymorphisms G-597A (rs1800797), G-572C (rs1800796) and G-174C (rs1800795) with the risk of SLE.
|
28530463 |
2017 |
|
rs1800797
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes.
|
25222779 |
2014 |
|
rs1800797
|
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Minor alleles of rs1800795 raised and rs1800797 reduced the risk of obesity, while rs1800796 and rs2069845 may not be associated.
|
31472475 |
2019 |