|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the prevalence of MTHFR C677T and prothrombin G20210A genotypes by polymerase chain reaction (PCR) followed by restriction enzyme digestion in 420 Chinese subjects: 53 with deep venous thrombosis (DVT); 145 with cerebrovascular disease [115 cerebral infarction, 30 cerebral haemorrhage (CH)]; 100 with coronary artery disease (CAD); and 122 control subjects.
|
10929044 |
2000 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In spite of the clear effect of C677T mutation on elevated homocysteine levels we only found an association between 1298AA genotype and CAD in this population.
|
18384842 |
2008 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
|
24218123 |
2013 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy).
|
15447919 |
2004 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study suggests that the C677T MTHFR mutation is associated with increased CAD risk in a sex-dependent manner in Brazilians.
|
18075008 |
2007 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gene-gene interactions within one-carbon metabolic pathway were observed in CAD (GCPII 1561 C>T, SHMT 1420 C>T and MTHFR 677 C>T) and PD (cSHMT 1420 C>T, MTRR 66 A>G and RFC1 80 G>A).
|
25648260 |
2015 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalences of the C677T and A1298C genotypes did not differ significantly in 772 individuals with documented coronary artery disease (CAD), 137 individuals with deep-vein thrombosis (DVT), and 329 individuals without documented vascular disease.
|
11274015 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine plasma homocysteine levels and the incidence of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in a group of subjects who underwent coronary angiography, in an attempt to establish a correlation between these parameters and the severity of coronary artery disease (CAD), as well as investigate the correlation between hyperhomocysteinemia and the presence of polymorphism.
|
17384833 |
2007 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and 1298A/C, of the methylenetetrahydrofolate reductase (MTHFR) gene on the risk of restenosis after stenting in patients with symptomatic coronary artery disease.
|
14604831 |
2003 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.
|
12049191 |
2002 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.
|
15648053 |
2006 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the Chinese Han population, the TT genotype for the MTHFR C677T gene appeared to be associated with increased CAD risk.
|
22146089 |
2012 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
|
16077191 |
2005 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest that there is no association between the C677T mutation of the human MTHFR gene and the risk of CAD or VT among Chinese in Taiwan.
|
11096270 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To test whether the T variant of the C677T polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) would associate with three distinct forms of vascular disease, abdominal aortic aneurysm (AAA), coronary artery disease (CAD) and peripheral vascular disease (PVD).
|
15996600 |
2005 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T polymorphism of the MTHFR gene is associated with hyperhomocysteinaemia, lipid dysregulation and the presence of CAD in this Tunisian Arab population.
|
16704755 |
2006 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the 677C-->T mutation of MTHFR is common and is associated with an increased risk of premature CAD in this population.
|
10595952 |
1999 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this work was to analyze the frequency of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in patients with CAD and its association with plasma homocysteine levels.
|
17505678 |
2007 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the coexistence of MTHFR C677T with FV-Leiden was seen in 10.4% of CAD patients compared 6.9% of controls (p = 0.001).
|
15353918 |
2004 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
|
18403793 |
2008 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with early onset of coronary artery disease in some populations with certain ethnic backgrounds.
|
18751630 |
2008 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
|
12801615 |
2003 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians.
|
22664498 |
2012 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration.
|
20530057 |
2010 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control association study, we examine the association of single nucleotide polymorphisms (SNPs) in paraoxonase 573 A/G genes, methylene tetrahydrofolate reductase (MTHFR) 677 C/T and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with CAD independently, as well as synergistically, in a north Indian population.
|
21769819 |
2011 |