|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to mild hyperhomocysteinemia and, therefore, to the incidence of coronary artery disease.
|
11319193 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Detection of C677T mutation of MTHFR in subject with coronary heart disease by hairpin probe with enzymatic color on microarray.
|
21802936 |
2011 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, while the C allele of the 677C/T MTHFR polymorphism is associated with type II diabetes mellitus in women, the T allele is associated with CAD only in normotensive subjects of Czech origin.
|
11386855 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
|
12387655 |
2002 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that, in our population, the MTHFR C677T mutation is rather common, but it does not appear to be associated per se to CAD.
|
9596662 |
1998 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study sample included 492 patients with early-onset CAD who were genotyped for the C677T mutation in the methylenetetrahydrofolate reductase gene or screened for elevated homocysteine from January 1997 to December 2002.
|
19733705 |
2009 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) is an established determinant of homocysteine plasma level (t-Hcys) while its association with coronary artery disease (CAD) seems to be more limited.
|
16268464 |
2005 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease.
|
27051002 |
2016 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism, and GpIIIa and PAI-1 genes are risk factors for CAD.
|
27805237 |
2017 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
High plasma homocysteine concentration had a direct effect on the risk of CAD independent of MTHFR 677C-->T genotypes.
|
18586656 |
2008 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Patients with angiographic evidence of CAD or clinical MI do not show an increased frequency of the C677T transition in the MTHFR gene.
|
9350916 |
1997 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase 677 C-->T mutation and coronary heart disease risk in UK Indian Asians.
|
11073851 |
2000 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we have investigated whether DNA damage is related to the C677T variant in the MTHFR gene and to plasma levels of Hcy, B12, and folate in patients with CAD.
|
12522558 |
2003 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
After adjustment for other risk factors for C</span>AD, plasma homocysteine (p = 0.89), MTHFR gene C677T (p = 0.38), or A1298C polymorphisms (p = 0.13) were not independent correlates of CAD.
|
15135689 |
2004 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study therefore investigated the MTHFR C677T SNP in young SA Indian males with CAD compared to young Indian and Black male controls.
|
26095803 |
2015 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease.
|
16274479 |
2005 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the analysis of the 12 studies, the odds ratio of CAD associated with the TT genotype (homozygous C677T polymorphism) was 1.18.
|
14728017 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T polymorphism of 5,10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20637366 |
2010 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common point mutation (C677T) in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with hyperhomocysteinemia, an independent risk factor and a strong predictor of mortality in patients with coronary artery disease (CAD).
|
15301885 |
2004 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of the 677 C-->T and 1298 A-->C compound heterozygosity was 9.6% for the BD group and 12.3% for the CAD group.
|
14521457 |
2003 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the present study show that there is no statistically significant association between the two polymorphisms in Factor VII gene, MTHFR C677T polymorphism, PT G20210A polymorphism, 4G/5G polymorphism of PAI-1 and CAD in Turkish population.
|
16472842 |
2007 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the incidence of methylene tetrahydrofolate reductase (MTHFR) gene 677C-->T polymorphism and plasma homocysteine (Hcy) levels in a group of subjects who underwent coronary angiography, in an attempt to establish a correlation between these parameters and the severity of coronary artery disease (CAD) and to investigate the correlation between hyperhomocysteinemia (HHcy) and the presence of 677C-->T polymorphism.
|
18074111 |
2008 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although three common MTHFR polymorphisms (C677T, A1298C, T1317C) have been reported, only polymorphism C677T has been investigated intensively as a risk factor for coronary artery disease (CAD).
|
11257266 |
2001 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this generally well-nourished population, men with the +/+ genotype for the C677T mutation in the methylenetetrahydrofolate reductase gene have no increase in risk of coronary heart disease, even when intake of folate or other B vitamins is low.
|
9708460 |
1998 |
|
rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease.
|
14560345 |
2003 |