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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration.
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20530057 |
2010 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease.
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15648053 |
2006 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
A common mutation (nucleotide 677 C-->T) has been described recently in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which results in a valine for alanine substitution, a thermolabile enzyme, and a tendency to elevate plasma homocysteine levels and which has been proposed to contribute importantly to coronary artery disease.
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8994411 |
1997 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
A common point mutation (C677T) in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with hyperhomocysteinemia, an independent risk factor and a strong predictor of mortality in patients with coronary artery disease (CAD).
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15301885 |
2004 |
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rs1217691063
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.
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12049191 |
2002 |
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rs1217691063
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
After adjustment for other risk factors for C</span>AD, plasma homocysteine (p = 0.89), MTHFR gene C677T (p = 0.38), or A1298C polymorphisms (p = 0.13) were not independent correlates of CAD.
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15135689 |
2004 |
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rs1217691063
|
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
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16077191 |
2005 |
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rs1217691063
|
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although three common MTHFR polymorphisms (C677T, A1298C, T1317C) have been reported, only polymorphism C677T has been investigated intensively as a risk factor for coronary artery disease (CAD).
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11257266 |
2001 |
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rs1217691063
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Circulating homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, renal function, presence of coronary artery disease (CAD) diagnosed by coronary angiography, and circulating folate and vitamin B12 status were assessed.
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17027242 |
2008 |
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rs1217691063
|
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Correlation between the 677C>T polymorphism in the methylene tetrahydrofolate reductase gene and serum homocysteine levels in coronary heart disease.
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27051002 |
2016 |
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rs1217691063
|
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Coronary Artery Disease
|
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0.100 |
GeneticVariation
|
BEFREE |
Detection of C677T mutation of MTHFR in subject with coronary heart disease by hairpin probe with enzymatic color on microarray.
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21802936 |
2011 |
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rs1217691063
|
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
Dynamic regulation of MTHFR mRNA expression and C677T genotype modulate mortality in coronary artery disease patients after revascularization.
|
17604826 |
2007 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
Gene-gene interactions within one-carbon metabolic pathway were observed in CAD (GCPII 1561 C>T, SHMT 1420 C>T and MTHFR 677 C>T) and PD (cSHMT 1420 C>T, MTRR 66 A>G and RFC1 80 G>A).
|
25648260 |
2015 |
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rs1217691063
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Coronary Artery Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
High plasma homocysteine concentration had a direct effect on the risk of CAD independent of MTHFR 677C-->T genotypes.
|
18586656 |
2008 |
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rs1217691063
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the 677C-->T mutation of MTHFR is common and is associated with an increased risk of premature CAD in this population.
|
10595952 |
1999 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
In addition, the coexistence of MTHFR C677T with FV-Leiden was seen in 10.4% of CAD patients compared 6.9% of controls (p = 0.001).
|
15353918 |
2004 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
In conclusion, while the C allele of the 677C/T MTHFR polymorphism is associated with type II diabetes mellitus in women, the T allele is associated with CAD only in normotensive subjects of Czech origin.
|
11386855 |
2001 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
In spite of the clear effect of C677T mutation on elevated homocysteine levels we only found an association between 1298AA genotype and CAD in this population.
|
18384842 |
2008 |
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rs1217691063
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Coronary Artery Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
In the analysis of the 12 studies, the odds ratio of CAD associated with the TT genotype (homozygous C677T polymorphism) was 1.18.
|
14728017 |
2001 |
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rs1217691063
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Coronary Artery Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
In the Chinese Han population, the TT genotype for the MTHFR C677T gene appeared to be associated with increased CAD risk.
|
22146089 |
2012 |
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rs1217691063
|
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Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD).
|
9622772 |
1998 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
In this case-control association study, we examine the association of single nucleotide polymorphisms (SNPs) in paraoxonase 573 A/G genes, methylene tetrahydrofolate reductase (MTHFR) 677 C/T and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with CAD independently, as well as synergistically, in a north Indian population.
|
21769819 |
2011 |
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rs1217691063
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Coronary Artery Disease
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0.100 |
GeneticVariation
|
BEFREE |
In this generally well-nourished population, men with the +/+ genotype for the C677T mutation in the methylenetetrahydrofolate reductase gene have no increase in risk of coronary heart disease, even when intake of folate or other B vitamins is low.
|
9708460 |
1998 |
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rs1217691063
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Coronary Artery Disease
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|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we have investigated whether DNA damage is related to the C677T variant in the MTHFR gene and to plasma levels of Hcy, B12, and folate in patients with CAD.
|
12522558 |
2003 |
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rs1217691063
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
|
12801615 |
2003 |