|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Previous work has revealed a genetic association between Takayasu arteritis and a non-coding genetic variant in an enhancer region within <i>IL6</i> (rs2069837 A/G).
|
31315839 |
2019 |
|
rs2069837
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs12524487
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.
|
26996483 |
2016 |
|
rs12524487
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs12524487 in HLA-B/MICA was a genetic risk factor for TA in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
|
28261975 |
2018 |
|
rs10919543
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Among the four SNPs, rs10919543 was found to be significantly associated with TA in the studied population.
|
26996483 |
2016 |
|
rs10919543
|
|
Takayasu Arteritis
|
|
0.720 |
GeneticVariation
|
BEFREE |
In addition, we identified and confirmed a genetic association between Takayasu arteritis and the FCGR2A/FCGR3A locus on chromosome 1 (rs10919543, OR = 1.81, p = 5.89 × 10(-12)).
|
23830517 |
2013 |
|
rs2099684
|
|
Takayasu Arteritis
|
|
0.710 |
GeneticVariation
|
BEFREE |
The allele and genotype distributions for the other polymorphisms were not significantly associated with TA among the Han Chinese patients.The SNP rs2099684 in FCGR2A/FCGR3A can be considered a genetic risk factor for TA in the Chinese Han population.
|
27769046 |
2017 |
|
rs11666543
|
|
Takayasu Arteritis
|
|
0.710 |
GeneticVariation
|
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs6871626
|
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common component of IL-12p70 and IL-23.
|
28874185 |
2017 |
|
rs6871626
|
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Thus, our study points to potential diagnostic use of SNP rs6871626 for predicting disease severity of TAK, with the goal of genotyping-oriented therapy in the near future.
|
25783557 |
2016 |
|
rs6871626
|
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We also found that rs6871626 showed a significant association with clinical manifestations of TAK, including increased risk and severity of aortic regurgitation, a representative severe complication of TAK.
|
23830516 |
2013 |
|
rs6871626
|
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD.
|
28449344 |
2017 |
|
rs6871626
|
|
Takayasu Arteritis
|
|
0.050 |
GeneticVariation
|
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs665268
|
|
Takayasu Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
MLX-Q139R mutation plays a crucial role in the pathogenesis of TAK through promoting inflammasome formation.
|
30354298 |
2018 |
|
rs665268
|
|
Takayasu Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.
|
26996483 |
2016 |
|
rs56167332
|
|
Takayasu Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10(-8)).
|
23830517 |
2013 |
|
rs56167332
|
|
Takayasu Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.
|
26996483 |
2016 |
|
rs2476601
|
|
Takayasu Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene.
|
18375974 |
2008 |
|
rs2476601
|
|
Takayasu Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This is the first report documenting an association between PTPN22 R620W and TA.
|
30470857 |
2019 |
|
rs9366782
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs12524487 in HLA-B/MICA was a genetic risk factor for TA in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
|
28261975 |
2018 |
|
rs763780
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
G allele of rs763780 in IL-17F gene was protectively associated against susceptibility to TA.
|
28438554 |
2018 |
|
rs60689680
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs582054
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, a trend for IL12A rs582054 and IL23R rs1004819 in association with the TA phenotype was detected.
|
26987707 |
2016 |
|
rs4921493
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs4921492
|
|
Takayasu Arteritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |