|
rs1800795
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that CP is associated with the genetic polymorphism IL-6 (rs1800795).
|
21291465 |
2011 |
|
rs1800795
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions.
|
24314052 |
2013 |
|
rs1476413
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analysis found statistically significant difference in allele and genotype frequencies between cases with both CP and MR (CP + MR) compared with both CP-only cases and controls at rs4846049, rs1476413 and rs1801131.
|
20962791 |
2011 |
|
rs1476413
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study aims to examine whether the presence of polymorphisms in TNF-α (rs361525 and rs1799724) and MTHFR (rs1476413 and rs9651118) genes is associated with the pathogenesis of cerebral palsy (CP).
|
26646537 |
2016 |
|
rs9653711
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotype CTTG for rs6517135-rs1005573-rs6517137-rs9653711 in OLIG2 was also significantly associated with the occurrence of CP in infants with HIE (p = 0.01, OR = 0.521).
|
30178266 |
2019 |
|
rs9651118
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, a significant increase in the risk of CP was observed to be associated with the interactions of TNF-α rs1799724 and MTHFR rs9651118 (OR 2.75, 95 % CI 1.23-6.13).
|
26646537 |
2016 |
|
rs7964786
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of in vitro studies suggest that C alleles of rs10431386 and rs7964786 on MLEC promotes CP by inhibiting M1 to M2 macrophage polarization.
|
28972276 |
2018 |
|
rs769446
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association was detected between the e4 identified by the C allele of rs429358 and CP, but there were significant differences in allelic frequencies between the CP patients and controls at rs769446 (P = 0.005, P = 0.025 after Bonferroni correction), as well as between the CP patients with preterm birth (<34 gestational weeks) and controls at rs769446 (P = 0.001, P = 0.005 after Bonferroni correction).
|
24522486 |
2014 |
|
rs765462548
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Free energy landscape analysis revealed the presence of multiple energy minima, suggesting that R135T and D157Y mutations destabilize and alter the conformational dynamics of STN1 and thus may be associated with the CP syndrome.
|
31245382 |
2019 |
|
rs6568431
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, mean plasma ATG5 levels were lower in CP patients than in controls, and individuals carrying the AA genotype of rs6568431 that was positively associated with CP had lower plasma ATG5 levels (<i>P</i> < 0.05).
|
29326554 |
2017 |
|
rs6517137
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotype CTTG for rs6517135-rs1005573-rs6517137-rs9653711 in OLIG2 was also significantly associated with the occurrence of CP in infants with HIE (p = 0.01, OR = 0.521).
|
30178266 |
2019 |
|
rs6517135
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found marginal association of the SNP rs6517135 with CP (p = 0.044) at the genotype level, and the association was greatly strengthened when we focused on the subgroup of CP infants who suffered from hypoxic-ischemic encephalopathy (HIE) after birth, with p = 0.003 (OR = 0.558) at the allele level and p = 0.007 at the genotype level, indicating a risk-associated role of the T allele of the SNP rs6517135 under HIE conditions.
|
30178266 |
2019 |
|
rs59007384
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Children with CP were more likely than expected to carry the APOEε3 allele (RR 7.5; CI: 0.99-53.7 for heterozygotes and 10.3; CI: 1.4-79.6 for homozygotes), and to have the haplotype of APOEε3 and rs59007384 G (RR 2.4; CI: 1-5.7 for heterozygotes, RR 3.7; CI: 1.4-9.5 for homozygotes) whereas the distribution was as expected for rs59007384 alone.
|
25596901 |
2015 |
|
rs4986790
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigates associations between selected inflammatory mediator and cytokine gene polymorphisms (Toll-like receptor-4 (TLR-4) Asp299Gly, interleukin-6 G-174C and interleukin-4 C-589T) and CP from 443 CP infants and 883 control infants.
|
19566553 |
2009 |
|
rs4846049
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis found statistically significant difference in allele and genotype frequencies between cases with both CP and MR (CP + MR) compared with both CP-only cases and controls at rs4846049, rs1476413 and rs1801131.
|
20962791 |
2011 |
|
rs4754
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform.
|
27114095 |
2016 |
|
rs429358
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association was detected between the e4 identified by the C allele of rs429</span>358 and CP, but there were significant differences in allelic frequencies between the CP patients and controls at rs769446 (P = 0.005, P = 0.025 after Bonferroni correction), as well as between the CP patients with preterm birth (<34 gestational weeks) and controls at rs769446 (P = 0.001, P = 0.005 after Bonferroni correction).
|
24522486 |
2014 |
|
rs405509
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
A haplotype consisting of the five SNPs rs769446(C), rs405509(C), rs121918399(C), rs429358(T), and rs190853081(G) was associated with a decreased risk of CP (P = 0.002 after Bonferroni correction).
|
24522486 |
2014 |
|
rs3802169
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We revealed that the rare alleles T of rs3802169 and G of rs191727850 were found to be associated with an increased risk of cerebral palsy (OR=3.71, 95% CI 1.74-7.92 and OR=2.18, 95% CI 1.36-3.49, respectively).
|
29770797 |
2018 |
|
rs3741475
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis revealed differences in genotype frequencies between the CP with neonatal encephalopathy group (CP + NE) and control group for rs10774909, rs3741475, and rs2682826 (after SNPSpD correction, p = 0.004, 0.012, and 0.002, respectively).
|
29940959 |
2018 |
|
rs361525
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis based on gestational age indicated a significant association between rs361525 and rs9651118 and CP with or without premature.
|
26646537 |
2016 |
|
rs3024490
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-10 polymorphisms and protein association analysis showed that the TT genotype had higher plasma IL-10 protein levels compared to the GG + GT genotype at rs3024490 (11.14 ± 7.27 vs. 7.44 ± 6.95 pg/ml, <i>p</i> = 0.045, respectively) in CP cases.
|
29623066 |
2018 |
|
rs2853749
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform.
|
27114095 |
2016 |
|
rs2853744
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform.
|
27114095 |
2016 |
|
rs2735835
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the original population, SNP rs2735835 was associated with CP; the minor allele A was underrepresented in cases compared to controls (OR = 0.42, 95% CI: 0.21-0.83, p = 0.01).
|
26113374 |
2015 |