|
rs1001179
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
CAT rs1001179 polymorphism could be used to identify children that have a higher susceptibility to cerebral palsy after perinatal HIE.
|
27302388 |
2016 |
|
rs1005573
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotype CTTG for rs6517135-rs1005573-rs6517137-rs9653711 in OLIG2 was also significantly associated with the occurrence of CP in infants with HIE (p = 0.01, OR = 0.521).
|
30178266 |
2019 |
|
rs1042714
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In white non-Hispanic children, beta-2 adrenergic receptor gln27glu was associated with CP risk; in Hispanic children, plasminogen activator inhibitor-1 (PAI-1) 4G(-675)5G and G11053T were associated with risk of CP.
|
15718364 |
2005 |
|
rs10431386
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of in vitro studies suggest that C alleles of rs10431386 and rs7964786 on MLEC promotes CP by inhibiting M1 to M2 macrophage polarization.
|
28972276 |
2018 |
|
rs1057519583
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Free energy landscape analysis revealed the presence of multiple energy minima, suggesting that R135T and D157Y mutations destabilize and alter the conformational dynamics of STN1 and thus may be associated with the CP syndrome.
|
31245382 |
2019 |
|
rs1060499939
|
|
Cerebral Palsy
|
C |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs1060499939
|
|
Cerebral Palsy
|
T |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs10774909
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis revealed differences in genotype frequencies between the CP with neonatal encephalopathy group (CP + NE) and control group for rs10774909, rs3741475, and rs2682826 (after SNPSpD correction, p = 0.004, 0.012, and 0.002, respectively).
|
29940959 |
2018 |
|
rs1126616
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found an association between rs1126616 and global CP (corrected allelic P = 0.0006 and genotypic P = 0.0011 after Bonferroni correction).
|
27114095 |
2016 |
|
rs1131692230
|
|
Cerebral Palsy
|
G |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs11728697
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
To explore the genetic association between OPN gene single nucleotide polymorphisms (SNPs) and CP in the Chinese Han population, five SNPs (rs2853744, rs2853749, rs11728697, rs4754, and rs1126616) were genotyped among 715 CP patients and 658 healthy controls using the MassArray platform.
|
27114095 |
2016 |
|
rs1191926239
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigates associations between selected inflammatory mediator and cytokine gene polymorphisms (Toll-like receptor-4 (TLR-4) Asp299Gly, interleukin-6 G-174C and interleukin-4 C-589T) and CP from 443 CP infants and 883 control infants.
|
19566553 |
2009 |
|
rs1217401
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis showed that rs1217401 of AP4B1 was significantly associated with CP as a sequela of hypoxic-ischemic encephalopathy (HIE) (CP + HIE) (allele: p = 0.042151; genotype: p = 4.46 × 10(-6)).
|
24065543 |
2013 |
|
rs1217691063
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
MTHFR C677T approximately doubles the risk of CP in preterm infants.
|
16202738 |
2005 |
|
rs121918399
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
A haplotype consisting of the five SNPs rs769446(C), rs405509(C), rs121918399(C), rs429358(T), and rs190853081(G) was associated with a decreased risk of CP (P = 0.002 after Bonferroni correction).
|
24522486 |
2014 |
|
rs121918455
|
|
Cerebral Palsy
|
G |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs1345176461
|
|
Cerebral Palsy
|
A |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|
|
rs1411040
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant association was found for an association between CP and rs1961495 (allele: p = 0.008, odds ratio (OR) = 1.387, 95% confidence interval (CI) = 1.088-1.767) and rs1411040 (allele: p = 0.009, OR = 1.746, 95% CI = 1.148-2.656) SNPs of the COL4A1 gene.
|
26748532 |
2016 |
|
rs1476413
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analysis found statistically significant difference in allele and genotype frequencies between cases with both CP and MR (CP + MR) compared with both CP-only cases and controls at rs4846049, rs1476413 and rs1801131.
|
20962791 |
2011 |
|
rs1476413
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study aims to examine whether the presence of polymorphisms in TNF-α (rs361525 and rs1799724) and MTHFR (rs1476413 and rs9651118) genes is associated with the pathogenesis of cerebral palsy (CP).
|
26646537 |
2016 |
|
rs1477816966
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) showing evidence of association with development of CP were endothelial nitric oxide synthase (eNOS) A(-922)G, factor 7 (F7) arg353gln and del(-323)10bp-ins, and lymphotoxin A (LTA) thr26asn.
|
15718364 |
2005 |
|
rs1553630279
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
Clinical features associated with CTNNB1 de novo loss of function mutations in ten individuals.
|
27915094 |
2017 |
|
rs1553630279
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
[Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass].
|
2614104 |
1989 |
|
rs1553630279
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
A new intellectual disability syndrome caused by CTNNB1 haploinsufficiency.
|
24668549 |
2014 |
|
rs1554208945
|
|
Cerebral Palsy
|
C |
0.700 |
GeneticVariation
|
CLINVAR |
|
|
|