|
rs564185858
|
|
Cerebral Palsy
|
A |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs1042714
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In white non-Hispanic children, beta-2 adrenergic receptor gln27glu was associated with CP risk; in Hispanic children, plasminogen activator inhibitor-1 (PAI-1) 4G(-675)5G and G11053T were associated with risk of CP.
|
15718364 |
2005 |
|
rs1217401
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analysis showed that rs1217401 of AP4B1 was significantly associated with CP as a sequela of hypoxic-ischemic encephalopathy (HIE) (CP + HIE) (allele: p = 0.042151; genotype: p = 4.46 × 10(-6)).
|
24065543 |
2013 |
|
rs769446
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association was detected between the e4 identified by the C allele of rs429358 and CP, but there were significant differences in allelic frequencies between the CP patients and controls at rs769446 (P = 0.005, P = 0.025 after Bonferroni correction), as well as between the CP patients with preterm birth (<34 gestational weeks) and controls at rs769446 (P = 0.001, P = 0.005 after Bonferroni correction).
|
24522486 |
2014 |
|
rs429358
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant association was detected between the e4 identified by the C allele of rs429</span>358 and CP, but there were significant differences in allelic frequencies between the CP patients and controls at rs769446 (P = 0.005, P = 0.025 after Bonferroni correction), as well as between the CP patients with preterm birth (<34 gestational weeks) and controls at rs769446 (P = 0.001, P = 0.005 after Bonferroni correction).
|
24522486 |
2014 |
|
rs405509
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
A haplotype consisting of the five SNPs rs769446(C), rs405509(C), rs121918399(C), rs429358(T), and rs190853081(G) was associated with a decreased risk of CP (P = 0.002 after Bonferroni correction).
|
24522486 |
2014 |
|
rs190853081
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
A haplotype consisting of the five SNPs rs769446(C), rs405509(C), rs121918399(C), rs429358(T), and rs190853081(G) was associated with a decreased risk of CP (P = 0.002 after Bonferroni correction).
|
24522486 |
2014 |
|
rs121918399
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
A haplotype consisting of the five SNPs rs769446(C), rs405509(C), rs121918399(C), rs429358(T), and rs190853081(G) was associated with a decreased risk of CP (P = 0.002 after Bonferroni correction).
|
24522486 |
2014 |
|
rs6568431
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, mean plasma ATG5 levels were lower in CP patients than in controls, and individuals carrying the AA genotype of rs6568431 that was positively associated with CP had lower plasma ATG5 levels (<i>P</i> < 0.05).
|
29326554 |
2017 |
|
rs606231435
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs1001179
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
CAT rs1001179 polymorphism could be used to identify children that have a higher susceptibility to cerebral palsy after perinatal HIE.
|
27302388 |
2016 |
|
rs2735835
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the original population, SNP rs2735835 was associated with CP; the minor allele A was underrepresented in cases compared to controls (OR = 0.42, 95% CI: 0.21-0.83, p = 0.01).
|
26113374 |
2015 |
|
rs1555303073
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
rs1961495
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant association was found for an association between CP and rs1961495 (allele: p = 0.008, odds ratio (OR) = 1.387, 95% confidence interval (CI) = 1.088-1.767) and rs1411040 (allele: p = 0.009, OR = 1.746, 95% CI = 1.148-2.656) SNPs of the COL4A1 gene.
|
26748532 |
2016 |
|
rs1411040
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant association was found for an association between CP and rs1961495 (allele: p = 0.008, odds ratio (OR) = 1.387, 95% confidence interval (CI) = 1.088-1.767) and rs1411040 (allele: p = 0.009, OR = 1.746, 95% CI = 1.148-2.656) SNPs of the COL4A1 gene.
|
26748532 |
2016 |
|
rs1553630279
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
Clinical features associated with CTNNB1 de novo loss of function mutations in ten individuals.
|
27915094 |
2017 |
|
rs1553630279
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
[Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass].
|
2614104 |
1989 |
|
rs1553630279
|
|
Cerebral Palsy
|
T |
0.700 |
CausalMutation
|
CLINVAR |
A new intellectual disability syndrome caused by CTNNB1 haploinsufficiency.
|
24668549 |
2014 |
|
rs3024490
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-10 polymorphisms and protein association analysis showed that the TT genotype had higher plasma IL-10 protein levels compared to the GG + GT genotype at rs3024490 (11.14 ± 7.27 vs. 7.44 ± 6.95 pg/ml, <i>p</i> = 0.045, respectively) in CP cases.
|
29623066 |
2018 |
|
rs1800871
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The differences in the rs3024490 (<i>p</i> = 0.033) and rs1800871 (<i>p</i> = 0.033) allele frequencies of <i>IL-10</i> were determined between CP patients and controls.
|
29623066 |
2018 |
|
rs16944
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association Between rs3833912/rs16944 SNPs and Risk for Cerebral Palsy in Mexican Children.
|
29931509 |
2019 |
|
rs2069837
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Differences were found between spastic CP and controls in males for rs2069837; between CP with periventricular leukomalacia and controls in males for rs1800796 and rs2066992; and between term CP and controls in males for rs2069837.
|
24903966 |
2014 |
|
rs2066992
|
|
Cerebral Palsy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Differences were found between spastic CP and controls in males for rs2069837; between CP with periventricular leukomalacia and controls in males for rs1800796 and rs2066992; and between term CP and controls in males for rs2069837.
|
24903966 |
2014 |
|
rs1800795
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis demonstrated that CP is associated with the genetic polymorphism IL-6 (rs1800795).
|
21291465 |
2011 |
|
rs1800795
|
|
Cerebral Palsy
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), rs1800795, in the promoter region of the interleukin-6 (IL6) gene has been implicated in the pathogenesis of CP by mediating IL-6 protein levels in amniotic fluid and cord plasma and within brain lesions.
|
24314052 |
2013 |