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rs1800470
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Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
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18827819 |
2008 |
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rs1800470
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|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our analysis suggested that 29T/C</span> has no association with a trend of breast cancer</span> risk when using both dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI) 0.96-1.07] and recessive models (OR = 0.98, 95% CI 0.89-1.08) to analyze the data.
|
20845106 |
2010 |
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rs1800470
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conclusively, this meta-analysis strongly suggests that TGFB1 L10P polymorphism may play a low penetrance role in breast cancer susceptibility in Caucasian.
|
20349130 |
2010 |
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rs1800470
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Consecutive patients (n = 660) with breast cancer from the Memorial Sloan-Kettering Cancer Center (New York, NY) and healthy females (n = 880) from New York City were genotyped for the hypomorphic TGFBR1*6A allele and for the TGFB1 T29C variant that results in increased TGF-beta circulating levels.
|
15833881 |
2005 |
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rs1800470
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects.
|
20143152 |
2010 |
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rs1800470
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers.
|
18523885 |
2009 |
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rs1800470
|
|
Carcinoma of bladder
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|
0.010 |
GeneticVariation
|
BEFREE |
We found that c.29C>T substitution increased the risk of bladder cancer significantly and recessive model of analysis was the best fitted model (p=0.004; OR=1.72 95% CI 1.18-2.50).
|
26048435 |
2015 |
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rs1800470
|
|
Carcinoma of lung
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|
0.020 |
GeneticVariation
|
BEFREE |
To test this hypothesis, we investigated the association of the TGF-beta1 -509C > T and 869T > C (L10P) polymorphisms and their haplotypes with the risk of lung cancer in a Korean population.
|
16499994 |
2006 |
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rs1800470
|
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Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that rs1800470 polymorphism was a risk factor of lung cancer.
|
25409890 |
2014 |
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rs1800470
|
|
Cardiomyopathy, Dilated
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|
0.010 |
GeneticVariation
|
BEFREE |
The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD.
|
11557193 |
2001 |
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rs1800470
|
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Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggests there might be an association between the TGFβ1 29C>T polymorphism and CVD risk in long-term breast cancer survivors.
|
22100658 |
2012 |
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rs1800470
|
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Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association between the TGF-beta1 polymorphisms and myocardial infarction was observed; however, the -509 C/T and codon 10 Leu/Pro polymorphisms were associated with the risk of stroke.
|
17023672 |
2006 |
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rs1800470
|
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Childhood asthma
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|
0.010 |
GeneticVariation
|
BEFREE |
The three loci (NOS1 C5266T, TGF-beta1 L10P and TGF-beta1 R25P) have little contribution to the development of childhood asthma in Chinese Han Nationality.
|
19657898 |
2009 |
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rs1800470
|
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Childhood Osteosarcoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms.
|
29228633 |
2017 |
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rs1800470
|
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Childhood Osteosarcoma
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|
0.020 |
GeneticVariation
|
BEFREE |
The morbidity and metastasis of osteosarcoma are relevant to TGF-β1 gene 29 T > C single nucleotide polymorphism.
|
25663491 |
2015 |
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rs1800470
|
|
Chronic kidney disease stage 5
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results conclude that TGF-β1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-β1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir.
|
25871499 |
2015 |
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rs1800470
|
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Of these variants, four were significantly associated with COPD susceptibility in random effects meta-analysis, the GSTM1 null variant (OR 1.45, CI 1.09-1.92), rs1800470 in TGFB1 (0.73, CI 0.64-0.83), rs1800629 in TNF (OR 1.19, CI 1.01-1.40) and rs1799896 in SOD3 (OR 1.97, CI 1.24-3.13).
|
19933216 |
2010 |
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rs1800470
|
|
Chronic Obstructive Airway Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Two SNPs in TGFB1 (C to T substitution at nucleotide -509 and substitution of leucine 10 with proline (Leu10Pro)), Leu50Val in SFTPA1 and Ala160Thr in SFTPD showed evidence suggestive of association with FEV(1)/IVC in subjects with GOLD stage >or=2 COPD.
|
19797132 |
2010 |
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rs1800470
|
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Chronic Obstructive Airway Disease
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|
0.030 |
GeneticVariation
|
BEFREE |
The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968, and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives.
|
27323020 |
2016 |
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rs1800470
|
|
Chronic Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study shows that TGF-β1 29 C/T polymorphism, but not -509 C/T and 788 C/T polymorphisms, may contribute to the development of CP in a sample of Iranian population.
|
23352795 |
2013 |
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rs1800470
|
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Chronic Periodontitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study shows that there is a strong association between TGF-β1 29C/T gene polymorphisms and quantitative parameters of interdental papilla in patients with CP.
|
23688102 |
2014 |
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rs1800470
|
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this respect, we investigated the impact of functional genetic polymorphisms of TGF-beta1 (codon 10 Leu/Pro, codon 25 Arg/Pro), TNF-alpha (-308 G/A, -238 G/A) and angiotensinogen (-6 G/A) on the development of cirrhosis in HHC.
|
15941661 |
2005 |
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rs1800470
|
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated with CHB infection in a South-Eastern Iranian population.
|
28700046 |
2017 |
|
rs1800470
|
|
Congenital Dysplasia Of The Hip
|
|
0.020 |
GeneticVariation
|
BEFREE |
Data suggest association between TGFB1 29 T → C transition (rs1800470) and IL6 -572G → C transversion (rs1800796) with DDH, and also a possibility of TGF-beta1 and IL-6 interaction in DDH pathogenesis.
|
25603974 |
2015 |
|
rs1800470
|
|
Congenital Dysplasia Of The Hip
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found SNP rs1800470 in TGFB1 (OR = 1.255, P = 0.0004) and rs1800796 (OR = 0.84, P = 0.0228) in IL-6 to be significantly associated with DDH in this cohort.
|
28860542 |
2017 |