|
rs1800470
|
|
Diabetic Retinopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that the +869T/C(L10P) polymorphism in TGFβ1 gene would be a potential protect factor for DR.
|
24710116 |
2014 |
|
rs1800470
|
|
Periodontal Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association of transforming growth factor (TGF)-β1 29C/T gene polymorphisms with level of tissue breakdown and periodontal disease progression is not clear.
|
23688102 |
2014 |
|
rs1800470
|
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the NSCLC subgroup, we found that rs1800470 polymorphism could increase NSCLC risk (OR=1.36; 95%CI, 1.06-1.74; P=0.02).
|
25409890 |
2014 |
|
rs1800470
|
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The distribution of Leu10Pro (c.869T>C) genotype and allele frequencies in the control and GD groups were not significantly different.
|
24742542 |
2014 |
|
rs1800470
|
|
Silent myocardial ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, our data suggest that the IL-10-1082 A>G (rs1800896), TGF-β1-509 T>C (rs1800469), and TGF-β1 T29C (rs1800470) SNPs play an important role in the risk of developing SMI.
|
24060592 |
2014 |
|
rs1800470
|
|
Kidney Failure, Acute
|
|
0.010 |
GeneticVariation
|
BEFREE |
To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-β, and rs2430561 (+874 T/A) from IFN-γ may be a risk factor for ICU patients to the development of AKI and/or death.
|
25147823 |
2014 |
|
rs1800470
|
|
Nephrogenic Systemic Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined whether an intronic single-nucleotide polymorphism (SNP) in caveolin-1 (CAV1 rs4730751) and 2 coding SNPs in transforming growth factor-beta 1 (TGFB1 rs1800471, codon 25; and rs1800470, codon 10) were associated with the NSF phenotype.
|
23051628 |
2013 |
|
rs1800470
|
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The T29C polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with genetic susceptibility to acute coronary syndrome in Mexican patients.
|
22465044 |
2012 |
|
rs1800470
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
PCR-based assays were used to determine the genotypes of TGFB1 SNPs including TGFB1-509 C/T (rs1800469, in the promoter region), +868 T/C (rs1800470, in exon 1) and +913 G/C (rs1800471, in exon 1) in 414 subjects with established RA.
|
22513132 |
2012 |
|
rs1800470
|
|
Keloid
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC haplotype, composed of both c.29C>T and -509T>C variants, was observed more frequently among cases (Corrected p = 0.037, OR = 2.07, 95 % CI = 0.87-4.93), showing a 4.5-fold increased risk for keloid.
|
22805880 |
2012 |
|
rs1800470
|
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Applying a dominant model of inheritance, three TGF-β1 SNPs were significantly associated with CHD complications: The T alleles of rs1800469 (OR = 1.125, 95% CI 1.016-1.247, p = 0.031) and rs1800470 (OR = 1.146, 95% CI 1.026-1.279, p = 0.021); and the C allele of rs1800471 (OR = 1.207, 95% CI 1.037-1.406, p = 0.021).
|
22662243 |
2012 |
|
rs1800470
|
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggests there might be an association between the TGFβ1 29C>T polymorphism and CVD risk in long-term breast cancer survivors.
|
22100658 |
2012 |
|
rs1800470
|
|
Sarcopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
T allele of the 29C>T polymorphism in the transforming growth factor-β1 gene might be a risk factor of sarcopenia in a Japanese population.
|
22066986 |
2012 |
|
rs1800470
|
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results suggest that TGF-β1 T29C gene polymorphism could be involved in the risk of developing ACS in Mexican individuals.
|
22465044 |
2012 |
|
rs1800470
|
|
Aplastic Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Concerning TGFB1, although its polymorphisms are not related to AA susceptibility, P10L T allele (recessive model, OR = 0.18, p = .038) and CT haplotype (dominant model, OR = 5.68, p = .038) were associated with response to IST.
|
20953611 |
2011 |
|
rs1800470
|
|
Filarial Elephantiases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis.
|
21843572 |
2011 |
|
rs1800470
|
|
Secondary malignant neoplasm of lymph node
|
|
0.010 |
GeneticVariation
|
BEFREE |
TGF-β1 29T>C genetic polymorphism is an independent factor associated with lymph node metastasis in adenocarcinoma of the lung.
|
20506050 |
2010 |
|
rs1800470
|
|
Pulmonary Emphysema
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the genotypes examined, membership in cluster 1 (emphysema-predominant) was associated with TGFB1 SNP rs1800470.
|
20233420 |
2010 |
|
rs1800470
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
TGFbeta1 T29C polymorphism and cancer risk: a meta-analysis based on 40 case-control studies.
|
19963138 |
2010 |
|
rs1800470
|
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
In view of the essential role of transforming growth factorβ1 (TGFB1) on both inhibiting the development of early benign breast tumors as well as promoting tumor invasion, the association of TGFB1 L10P polymorphism and breast cancer risk has been widely reported, but results of previous studies were somewhat contradictory and underpowered.
|
20349130 |
2010 |
|
rs1800470
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
TGFbeta1 T29C polymorphism and cancer risk: a meta-analysis based on 40 case-control studies.
|
19963138 |
2010 |
|
rs1800470
|
|
Adenocarcinoma of lung (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
TGF-β1 29T>C genetic polymorphism is an independent factor associated with lymph node metastasis in adenocarcinoma of the lung.
|
20506050 |
2010 |
|
rs1800470
|
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The three loci (NOS1 C5266T, TGF-beta1 L10P and TGF-beta1 R25P) have little contribution to the development of childhood asthma in Chinese Han Nationality.
|
19657898 |
2009 |
|
rs1800470
|
|
Severe myopia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The previously reported association of the coding SNP rs1800470 with high myopia was successfully replicated.
|
19365037 |
2009 |
|
rs1800470
|
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that T29C TGFbeta1 gene polymorphism was associated to clinical characteristics suitable to recognize hypertensives with a higher severity of hypertension.
|
18821144 |
2008 |