|
rs11549467
|
|
Malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC).
|
24824937 |
2014 |
|
rs11549467
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC).
|
24824937 |
2014 |
|
rs11549467
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
The current findings suggest that HIF1A P582S polymorphism correlates with urinary cancers risk in Caucasian population, while A588T polymorphism may increase the risk of urinary cancers in Asian population and prostate cancer.
|
23723982 |
2013 |
|
rs11549467
|
|
Malignant Neoplasms
|
|
0.040 |
GeneticVariation
|
BEFREE |
Compared with rs11549467 GG genotype, the variant genotypes GA+AA had a significantly increased PCa risk (adjusted odds ratio (OR)=1.70; 95% confidence interval (CI)=1.06-2.72), particularly among older patients (OR=2.01; 95%CI=1.05-3.86), smokers (OR=2.06; 95%CI=1.07-3.99), never drinkers (OR=2.16; 95%CI=1.20-3.86) and patients without a family history of cancer (OR=1.71; 95%CI=1.02-2.89).
|
23042446 |
2012 |
|
rs11549467
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
However, the combined variant genotypes of rs2057482 and rs11549467 were associated with increased PCa risk (OR=2.10; 95%CI=1.23-3.57 among subjects carrying three or more risk alleles).
|
23042446 |
2012 |
|
rs11549467
|
|
Malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
The roles of the polymorphic HIF-1α variants, C1772T (P582S) and G1790A (A588T), which are known to enhance transcriptional activity, were evaluated in lung cancers.
|
21435097 |
2011 |
|
rs11549467
|
|
Malignant neoplasm of lung
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this study, we have investigated the relationship between seven HIF-1alphapolymorphisms [C > T substitution in intron 8 (rs10873142), T418I (rs41508050) in exon 10, P564P (rs41492849), L580L (rs34005929), P582S (rs11549465), A588T (rs11549467) in exon 12 and dinucleotide GT repeats in intron 13 (rs10645014)] among lung cancer patients in the Turkish population.
|
19546348 |
2009 |
|
rs11549467
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
|
rs11549467
|
|
Malignant neoplasm of prostate
|
|
0.040 |
GeneticVariation
|
BEFREE |
No significant differences were found between the frequencies of A588T mutation in prostate cancer patients and controls.
|
16998808 |
2007 |
|
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
While under normoxic conditions the expression of glycolysis-related genes showed no correlation with origin or BRAF mutation status, GLUT1 expression was significantly elevated in metastatic and BRAF-V600E mutated melanoma cell lines under hypoxic conditions.
|
31791701 |
2020 |
|
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The present study evaluated the effect of hypoxia on three BRAF-V600E mutant melanoma cell lines, M14, A375 and 518A2, treated with vemurafenib.
|
26936534 |
2016 |
|
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
ETV1 expression is a rare event in human melanoma and seems to be rather based on hyperactivation of MAPK signals, by BRAF (V600E) mutation, than on ETV1 gene amplification.
|
25073704 |
2014 |
|
rs763538721
|
|
melanoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our data show for the first time that BRAF(V600E) mutation increases HIF-1alpha expression and melanoma cell survival under hypoxic conditions and suggest that effects of the oncogenic V600E BRAF mutation may be partially mediated through the HIF-1alpha pathway.
|
17409425 |
2007 |
|
rs11549465
|
|
Diabetic Nephropathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recent work has shown that the <i>HIF-1A</i> Pro582Ser polymorphism is more resistant to hyperglycemia-mediated repression, thus protecting against the development of diabetic nephropathy.
|
31214621 |
2019 |
|
rs11549465
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.
|
30539853 |
2018 |
|
rs11549465
|
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.
|
30539853 |
2018 |
|
rs11549465
|
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that HIF1A+1772C/T (rs11549465) polymorphism may have effects on RCC recurrence/progression and survival.
|
28476527 |
2017 |
|
rs11549465
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
These results suggest that HIF1A+1772C/T (rs11549465) polymorphism may have effects on RCC recurrence/progression and survival.
|
28476527 |
2017 |
|
rs11549465
|
|
Diabetic Nephropathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
HIF-1α Pro582Ser single nucleotide polymorphisms may be correlated with type 2 DN, which needs further exploration.
|
26600509 |
2015 |
|
rs11549465
|
|
Diabetic Nephropathy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The current study demonstrates for the first time that HIF1A Pro582Ser polymorphism has an effect on DN, possibly by conferring a relative resistance to the repressive effect of glucose on HIF-1α.
|
22991450 |
2013 |
|
rs11549465
|
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
|
rs11549465
|
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In previous studies, the C1772T (P582S) or the G1790A (A588T) polymorphisms of the HIF-1alpha gene have been identified in renal cell carcinoma, head and neck and esophageal squamous cell carcinomas as well as colorectal and prostate cancers.
|
18949419 |
2008 |
|
rs11549467
|
|
Renal Cell Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis was performed to assess the relationship between HIF-1α C1772T (rs11549465)/G1790A (rs11549467) gene polymorphism and RCC risk.
|
30539853 |
2018 |
|
rs11549467
|
|
Primary malignant neoplasm of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |
|
rs11549467
|
|
Carcinoma of lung
|
|
0.030 |
GeneticVariation
|
BEFREE |
We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay.
|
27981753 |
2017 |