|
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
However, no significant difference was found between the ERCC2 rs13181 polymorphism and the risk of pancreatic cancer in the codominant, dominant, and recessive models.
|
27051038 |
2016 |
|
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The increasing evidence of XPD-Lys751Gln impact on the outcome of gemcitabine-cisplatin-based polychemotherapy leads to plan prospective studies to validate the role of this polymorphism as a new tool for optimization of the currently available treatments in pancreatic cancer.
|
23390054 |
2013 |
|
rs13181
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
|
16458430 |
2007 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study examined the main and interactive effect of 9 single-nucleotide polymorphisms (SNPs) (Arg194Trp, Arg280His, Arg399Gln, c.1254C>T, c.1517G>C, c.1471G>A, C310T, 539del542, and T1915C) of XRCC1 in contribution to pancreatic cancer (PC).
|
26418909 |
2016 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05).
|
24435745 |
2014 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
Yet only one polymorphism, XRCC1 Arg194Trp, appears to be involved in smoking-related cancers and in early onset pancreatic cancer.
|
17397816 |
2007 |
|
rs1799782
|
|
Pancreatic carcinoma
|
|
0.060 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We performed a meta-analysis of all relevant case-control studies that examined the association between MTHFR C677T polymorphism and pancreatic cancer risk.
|
23098468 |
2012 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The risk for PC was higher in individuals with MTHFR C677T or TT polymorphisms and a smoking habit (OR = 2.52, 95% CI = 1.05-6.09, P = 0.04).
|
21441790 |
2011 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We conducted a case-control study to assess the effect of alcohol on pancreatic cancer in conjunction with polymorphisms in one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), and thymidylate synthase (TS) variable number of tandem repeat.
|
18843018 |
2008 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Joint effect between MTHFR C677T polymorphism and smoking or drinking increased risk of pancreatic cancer in a super-multiplicative manner.
|
16234002 |
2005 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) were not associated with pancreatic cancer risk.
|
22901202 |
2012 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) are not associated with pancreatic cancer risk.
|
23167392 |
2012 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
We found that the C667T (but not the A1298C) polymorphism had a significant main effect on the risk of pancreatic cancer.
|
15941958 |
2005 |
|
rs397507444
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
First, we performed a case-control study of germline MTHFR polymorphisms (C677T, A1298C) in 303 patients with pancreatic cancer and 305 matched control subjects.
|
16234003 |
2005 |
|
rs762846821
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs762846821
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
K-ras<sup>LSL-G12D/+</sup>:: p53<sup>LSL-R172H/+</sup>:: Pdx-1-Cre (KPC) mice are an established model of pancreatic cancer that specifically express mutants of both K-ras and p53 in the pancreas by using Pdx-1-Cre.
|
28971839 |
2018 |
|
rs762846821
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
These results suggest that tsTAg synergistically promotes Kras(G12D) -associated PDAC formation, and our study identifies a new mouse model of PDAC that may allow a better understanding of the mechanism of carcinogenesis in pancreatic carcinoma, which shows a catastrophic clinical course.
|
25042889 |
2014 |
|
rs762846821
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The concomitant expression of oncogenic Kras(G12D) and mutant p53 (Trp53(R172H)) in the murine pancreas results in metastatic PDA that recapitulates the cognate features of human pancreatic cancer providing an excellent animal model to identify genes required for tumor progression.
|
22158044 |
2012 |
|
rs762846821
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs17107315
|
|
Pancreatic carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Patients with the N34S mutation presented with earlier symptom onset and more dilatation of the main pancreatic duct, followed by more frequent surgical and/or endoscopic intervention and pancreatic cancer development than those without SPINK1 mutations.
|
17238043 |
2007 |