|
rs111966833
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The SPINK1 mutations N34S and P55S occurred in five PC patients with a prevalence (4.1%) not significantly different from that observed (2.0%) in HC.
|
17072959 |
2006 |
|
rs1129055
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated the association of two CD86 polymorphisms, +1057G/A (rs1129055) and +2379G/C (rs17281995), with pancreatic cancer in the Chinese population.
|
22821131 |
2012 |
|
rs1130409
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs1131691014
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated.
|
21468597 |
2011 |
|
rs1131691014
|
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the increased risks of digestive tract cancers, especially for Asians, and for gastric cancer, colorectal cancer and gallbladder and pancreatic cancer.
|
21376265 |
2011 |
|
rs1131691021
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs1143684
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.
|
20966810 |
2011 |
|
rs1143684
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.
|
20966810 |
2011 |
|
rs11549465
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In subgroup analysis for cancer types, the two polymorphisms were only associated with increased risk of pancreatic cancer (P582S: SS vs. PP: OR = 2.51, 95% CI: 1.31, 4.81; SS vs.
|
24293391 |
2014 |
|
rs11549467
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
When stratified by study design, significantly elevated susceptibility to cancer was found among hospital-based studies.These findings suggested that the 1790G/A (rs11549467) genetic polymorphism may contribute to the susceptibility of cancers except gynecologic cancer, especially in homozygote comparison and recessive genetic model among Caucasian population, and this SNP was significantly associated with the lung cancer, pancreatic cancer and oral squamous cell carcinoma (OSCC).
|
24824937 |
2014 |
|
rs11554495
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer.
|
17039343 |
2006 |
|
rs11571836
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using an approach based on candidate genes whose roles in pancreatic cancer have been well known, we identified two new susceptibility loci. rs11571836 located in the BRCA2 3'-untranslated region was significantly associated with lower expression of BRCA2 transcript and increased pancreatic cancer risk [odds ratio = 1.30, 95% confidence interval = 1.14-1.47, P = 7.64 × 10(-5)] in a recessive manner. rs12939944 located in the MAP2K4 intron was associated with decreased risk (odds ratio = 0.82, 95% confidence interval = 0.74-0.91, P = 0.0001) in a dominant manner.
|
23299404 |
2013 |
|
rs11615
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs11644043
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three promising variants, rs11644043, rs11085754, and rs2073389 in the discovery stage comprising 310 cases and 457 controls were further genotyped in the validation stage containing 429 cases and 585 controls. rs11644043 in BRD7 and rs11085754 in SMARCA4 showed consistent significant association with increased risk of PC in both stages, with odds ratios (ORs) and 95% confidence interval (CI) of 2.04 (1.17-3.56) and 1.64 (1.16-2.33) in stage one, and 1.97 (1.24-3.14) and 1.45 (1.04-2.02) in stage two, respectively in a recessive model.
|
24585446 |
2015 |
|
rs11644322
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
WWOX rs11644322 represents a major predictive factor in gemcitabine-treated pancreatic cancer.
|
26857392 |
2016 |
|
rs11655237
|
|
Pancreatic carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
Long noncoding RNA LINC00673 has been widely explored for its role in the development and prognosis of many tumors, and 2 genome-wide association studies identified that LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer.
|
30286619 |
2019 |
|
rs11655237
|
|
Pancreatic carcinoma
|
|
0.720 |
GeneticVariation
|
BEFREE |
<b>Background:</b> Two genome-wide association studies (GWASs) identified LINC00673 rs11655237 was associated with susceptibility to pancreatic cancer.
|
31118802 |
2019 |
|
rs1176026649
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer.
|
17415588 |
2007 |
|
rs11943456
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
rs1194611372
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
On the base of cDNA microarray data, we investigated regulating mechanism of Gli1 to some members of S100A genes family in pancreatic cancer cell lines firstly.
|
25072505 |
2014 |
|
rs12029406
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results showed that the rs3790843 (GA vs GG: OR=0.86, CI=0.76-0.98, <i>P</i>=0.992; GA+AA vs GG: OR=0.83, CI=0.73-0.94, <i>P</i>=0.950; A vs G: OR=0.85, CI=0.78-0.93, <i>P</i>=0.802), rs3790844 (CC vs TT: OR=0.65, CI=0.54-0.78, <i>P</i>=0.617; CC vs TT+CT: OR=0.73, CI=0.62-0.85, <i>P</i>=0.742; C vs T: OR=0.78, CI=0.73-0.84, <i>P</i>=0.555) and rs12029406 (TT vs CC: OR=0.73, CI=0.61-0.89, <i>P</i>=0.483; TT vs CC+CT: OR=0.78, CI=0.66-0.92, <i>P</i>=0.648; T vs C: OR=0.87, CI=0.79-0.95, <i>P</i>=0.837) polymorphisms were associated statistically with the risk of pancreatic cancer.
|
29785120 |
2018 |
|
rs1209809979
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
rs121434592
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
AKT1 (E17K) mutation in pancreatic cancer.
|
18783292 |
2008 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
Joint effect between MTHFR C677T polymorphism and smoking or drinking increased risk of pancreatic cancer in a super-multiplicative manner.
|
16234002 |
2005 |
|
rs1217691063
|
|
Pancreatic carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
The risk for PC was higher in individuals with MTHFR C677T or TT polymorphisms and a smoking habit (OR = 2.52, 95% CI = 1.05-6.09, P = 0.04).
|
21441790 |
2011 |