|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The angiotensinogen gene M235T polymorphism is related to an increased risk of hypertension.
|
18698203 |
2008 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T polymorphism is more common in hypertension and preeclampsia in some populations.
|
18562701 |
2008 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T polymorphism in the AGT gene has been related to an increased risk of hypertension.
|
18575631 |
2008 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension.
|
17579251 |
2007 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results in multiethnic youth uncover an ethnicity and gender-specific effect of the AGT M235T polymorphism and a SES or ethnicity-specific effect of the AGTR1 L191L polymorphism on the progression of hypertension risk.
|
16790149 |
2006 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
People who carried both ACE ID (or DD) and AGT M235T MT (or MM) had more risk to have hypertension.
|
16685579 |
2006 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conflicting results are to be found in the literature on the relationship between the M235T polymorphism of the angiotensinogen (AGT) gene and hypertension.
|
16755155 |
2006 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Earlier studies suggested that a single nucleotide polymorphism (SNP) that converts methionine to threonine at amino acid 235 is associated with hypertension in the Caucasian population.
|
15854165 |
2006 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension.
|
16392768 |
2005 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The occurrence of the frequent ABCC6 gene mutation c.3421C>T (R1141X) and the hypertension-associated genetic variants T174M and M235T in the angiotensinogen (AGT) gene were determined.
|
16133423 |
2005 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The M235T variant of the AGT is significantly associated with essential hypertension whereas the genotype TT or allele T is a possible genetic marker or risk factor for hypertension in Malaysian subjects.
|
15811183 |
2005 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE I/D polymorphism does not contribute to the presence and severity of essential hypertension, while the AGT M235T TT genotype confers a significantly decreased risk for the development of hypertension in the population studied here.
|
15642127 |
2005 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.
|
15386947 |
2004 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of likelihood ratio test, only the set of haplotypes that constituted the A-6G and the M235T polymorphisms was associated with hypertension (chi2 = 20.91, P = 0.0008), which was mainly due to the increased frequency of the recombinant haplotypes (-6A identical with 235M and -6G identical with 235T), and a pathophysiological role in the predisposition to hypertension was hence indicated.
|
14970360 |
2004 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We carried out association studies and multivariate analyses including other candidate causal factors of HP such as the M235T variant of the angiotensinogen (AGT) gene, prepregnancy body mass index (BMI), and family history of hypertension in Japanese subjects.
|
15042429 |
2004 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ThrThr genotype of the angiotensinogen (AGT) Met235Thr polymorphism has been associated with elevated AGT levels, hypertension, increased heart disease risk, and improved blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitors.
|
14643574 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
|
12805070 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There were no differences in the prevalence of hypertension and the ages at the ESRD in relation to the AGT M235T and ATR A1166C polymorphisms.
|
12950120 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G-217A variant of the AGT gene was significantly associated with hypertension (P = 0.0047), but the A-6G and M235T polymorphisms were not (P = 0.17 and P = 0.33, respectively).
|
14597849 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study was the analysis of M235T mutation in the gene encoding angiotensinogen in Romanian women with different forms of hypertension during pregnancy.
|
12417054 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.
|
14610337 |
2003 |
|
rs699
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We here assessed the association between AGT M235T polymorphism and hypertension within the same population (1,245 subjects aged 40 years and over).
|
12661912 |
2003 |