|
rs10455872
|
|
Aortic Valve Stenosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS.
|
30482443 |
2019 |
|
rs10455872
|
|
Aortic Valve Stenosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Both LPA variants were associated with AS, with a per risk allele odds ratio of 1.34 (95% CI, 1.23-1.47; P = 1.7 × 10-10) for rs1</span>0455872 and 1.31 (95% CI, 1.09-1.58; P = 3.6 × 10-3) for rs3798220 after adjusting for age, age2, and sex.
|
29128868 |
2018 |
|
rs10455872
|
|
Aortic Valve Stenosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs10455872 variant, which is associated with higher lipoprotein(a) levels, is also associated with increased risk of AVS, suggesting that this association may be causal.
|
24704946 |
2014 |
|
rs1042031
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A missense mutation in the APOB gene was significantly associated with AS (rs1042031, E4181K, p = 0.00001).
|
21855833 |
2011 |
|
rs11591147
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
PCSK9 R46L carriers have lower levels of lipoprotein(a) and LDL cholesterol as well as reduced risk of aortic valve stenosis and myocardial infarction.
|
27218270 |
2016 |
|
rs1205
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis.
|
26473826 |
2015 |
|
rs1333049
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped the CAD-associated variants at the LPA (rs10455872) and 9p21 loci (rs1333049) in the GeneCAST (Genetics of Calcific Aortic STenosis) Consortium and conducted a meta-analysis for their association with AVS.
|
30482443 |
2019 |
|
rs1349963459
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we have found the association of the renalase Glu37Asp polymorphism with left ventricle hypertrophy in large group of females with aortic stenosis.
|
29065134 |
2017 |
|
rs1544410
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, rs1544410 polymorphism within the VDR gene, E2 and E4 alleles within the apoE gene, rs6254 polymorphism within the PTH gene, and rs1800871 polymorphism within the IL10 gene may be associated with aortic stenosis with low level of evidence.
|
24903972 |
2014 |
|
rs174547
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs1800871
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, rs1544410 polymorphism within the VDR gene, E2 and E4 alleles within the apoE gene, rs6254 polymorphism within the PTH gene, and rs1800871 polymorphism within the IL10 gene may be associated with aortic stenosis with low level of evidence.
|
24903972 |
2014 |
|
rs2228145
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interleukin-6 receptor Asp358Ala gene polymorphism is associated with plasma C-reactive protein levels and severity of aortic valve stenosis.
|
24717336 |
2014 |
|
rs2296545
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we have found the association of the renalase Glu37Asp polymorphism with left ventricle hypertrophy in large group of females with aortic stenosis.
|
29065134 |
2017 |
|
rs2528795
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The G allele of SNP rs2528795 in the ELN gene was associated with aortic stenosis in WS participants (p < 0.0049) while the A allele of the same SNP was associated with aortic dilation in Dup7.
|
29614955 |
2018 |
|
rs3798220
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Both LPA variants were associated with AS, with a per risk allele odds ratio of 1.34 (95% CI, 1.23-1.47; P = 1.7 × 10-10) for rs10455872 and 1.31 (95% CI, 1.09-1.58; P = 3.6 × 10-3) for rs3798220 after adjusting for age, age2, and sex.
|
29128868 |
2018 |
|
rs4762
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
In subjects with aortic stenosis, left ventricular RWT was higher in those with ACE DD (P < 0.05) or AGT T174M (P < 0.06) compared with those with the ACE II or ID genotype or AGT TT174 genotype.
|
8800593 |
1996 |
|
rs563655306
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the function and mechanism of two missense mutations, G184S and S192G, responsible for tetralogy of Fallot and aortic stenosis, respectively.
|
22735262 |
2012 |
|
rs6254
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, rs1544410 polymorphism within the VDR gene, E2 and E4 alleles within the apoE gene, rs6254 polymorphism within the PTH gene, and rs1800871 polymorphism within the IL10 gene may be associated with aortic stenosis with low level of evidence.
|
24903972 |
2014 |
|
rs9939609
|
|
Aortic Valve Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study revealed an association of FTO rs9939609 with AVS.
|
26431034 |
2015 |