Source: CURATED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 324
Gene Symbol: APC
APC 		P25054 APC regulator of WNT signaling pathway 95 0.373 0.962 1.00 0.900 None 0.982 7 12 1990 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53 		P04637 tumor protein p53 Transcription factor 232 0.236 0.962 0.53 0.700 None 0.989 8 67 1991 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		P35222 catenin beta 1 130 0.303 0.885 1.00 0.700 None 0.985 4 6 1997 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		P08253 matrix metallopeptidase 2 Enzyme 98 0.333 0.923 0.84 0.700 None 1.000 2 1 1996 2016
Entrez Id: 7298
Gene Symbol: TYMS
TYMS 		P04818 thymidylate synthetase Enzyme 67 0.425 0.846 0.72 0.600 None 1.000 11 0 1998 2015
Entrez Id: 1806
Gene Symbol: DPYD
DPYD 		Q12882 dihydropyrimidine dehydrogenase Enzyme 45 0.493 0.846 3.4E-22 0.600 None 0.952 5 0 1999 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 115 0.319 0.846 1.00 0.500 None 0.978 4 10 2002 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		P01116 KRAS proto-oncogene, GTPase Enzyme modulator 164 0.320 0.923 7.9E-04 0.500 None 0.983 3 12 1990 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4 		Q13485 SMAD family member 4 Transcription factor 47 0.401 0.808 1.00 0.500 None 1.000 3 8 1996 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		P00533 epidermal growth factor receptor Kinase 124 0.295 0.885 0.37 0.500 None 0.976 2 1 2003 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		P12830 cadherin 1 73 0.401 0.808 0.15 0.500 None 0.950 2 2 1999 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2 		Q9NQB0 transcription factor 7 like 2 29 0.485 0.846 1.00 0.490 None 1.000 2 2 2002 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA 		P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 98 0.292 0.923 1.00 0.490 None 1.000 0 32 2004 2019
Entrez Id: 26585
Gene Symbol: GREM1
GREM1 		O60565 gremlin 1, DAN family BMP antagonist 13 0.508 0.808 0.47 0.430 None 1.000 2 3 2008 2020
Entrez Id: 894
Gene Symbol: CCND2
CCND2 		P30279 cyclin D2 Enzyme modulator 42 0.477 0.808 0.99 0.420 None 1.000 1 3 2011 2019
Entrez Id: 688
Gene Symbol: KLF5
KLF5 		Q13887 Kruppel like factor 5 Nucleic acid binding 13 0.534 0.769 0.82 0.410 None 1.000 1 1 2008 2019
Entrez Id: 4092
Gene Symbol: SMAD7
SMAD7 		O15105 SMAD family member 7 Transcription factor 9 0.470 0.769 0.55 0.410 None 1.000 1 7 2007 2019
Entrez Id: 652
Gene Symbol: BMP4
BMP4 		P12644 bone morphogenetic protein 4 Signaling 28 0.422 0.808 0.96 0.410 None 1.000 1 1 2008 2019
Entrez Id: 91653
Gene Symbol: BOC
BOC 		Q9BWV1 BOC cell adhesion associated, oncogene regulated 5 0.666 0.423 1.7E-07 0.410 None 1.000 1 1 2018 2019
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		P01111 NRAS proto-oncogene, GTPase Enzyme modulator 67 0.390 0.808 0.49 0.410 None 1.000 0 6 2006 2016
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		P42898 methylenetetrahydrofolate reductase 192 0.337 0.885 3.2E-10 0.400 None 1.000 8 0 2002 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		P35354 prostaglandin-endoperoxide synthase 2 Enzyme 239 0.314 0.962 1.00 0.400 None 1.000 6 0 1999 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1 		P40692 mutL homolog 1 Nucleic acid binding 31 0.399 0.808 3.4E-05 0.400 None 1.000 3 0 1997 2019
Entrez Id: 10714
Gene Symbol: POLD3
POLD3 		Q15054 DNA polymerase delta 3, accessory subunit 2 0.631 0.462 1.00 0.400 None 1.000 2 3 2012 2019
Entrez Id: 5426
Gene Symbol: POLE
POLE 		Q07864 DNA polymerase epsilon, catalytic subunit 17 0.526 0.731 8.0E-27 0.400 None 1.000 2 3 2013 2016