Source: CURATED ×
Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 351
Gene Symbol: APP
APP 		P05067 amyloid beta precursor protein Enzyme modulator 76 0.422 0.846 4.7E-02 0.500 None 0.984 35 1 1991 2020
Entrez Id: 348
Gene Symbol: APOE
APOE 		P02649 apolipoprotein E 115 0.338 0.962 1.9E-03 0.500 None 0.935 9 1 1993 2020
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1 		P49768 presenilin 1 Enzyme 45 0.469 0.846 0.97 0.400 None 0.958 13 0 1995 2020
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2 		P49810 presenilin 2 Enzyme 16 0.550 0.654 5.4E-04 0.400 None 0.972 3 0 1997 2020
Entrez Id: 4137
Gene Symbol: MAPT
MAPT 		P10636 microtubule associated protein tau 66 0.446 0.923 6.0E-03 0.350 None 1.000 7 0 1999 2016
Entrez Id: 23385
Gene Symbol: NCSTN
NCSTN 		Q92542 nicastrin 10 0.666 0.462 1.00 0.340 None 0.800 1 0 2002 2007
Entrez Id: 54209
Gene Symbol: TREM2
TREM2 		Q9NZC2 triggering receptor expressed on myeloid cells 2 19 0.519 0.769 3.3E-09 0.330 None 1.000 2 0 2013 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1 		P56817 beta-secretase 1 Enzyme 8 0.559 0.769 0.88 0.330 None 1.000 1 0 1999 2018
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7 		Q8IZY2 ATP binding cassette subfamily A member 7 Transporter 10 0.644 0.577 2.1E-55 0.320 None 1.000 2 0 2011 2019
Entrez Id: 5621
Gene Symbol: PRNP
PRNP 		F7VJQ1 P04156 prion protein 43 0.445 0.923 6.3E-04 0.320 None 1.000 1 0 2000 2007
Entrez Id: 1471
Gene Symbol: CST3
CST3 		P01034 cystatin C 55 0.436 0.808 3.9E-03 0.310 None 1.000 2 0 1993 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		P01375 tumor necrosis factor Signaling 340 0.231 0.962 0.80 0.310 None 1.000 1 0 2007 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE 		P12821 angiotensin I converting enzyme Enzyme 101 0.328 0.923 1.0E-37 0.300 None 1.000 5 0 1999 2019
Entrez Id: 10452
Gene Symbol: TOMM40
TOMM40 		O96008 translocase of outer mitochondrial membrane 40 Transporter 12 0.590 0.538 0.99 0.300 None 1.000 4 0 2017 2018
Entrez Id: 23607
Gene Symbol: CD2AP
CD2AP 		Q9Y5K6 CD2 associated protein 11 0.558 0.731 0.23 0.300 None 1.000 3 0 2011 2018
Entrez Id: 2
Gene Symbol: A2M
A2M 		P01023 alpha-2-macroglobulin Enzyme modulator 26 0.529 0.769 4.5E-11 0.300 None 1.000 3 0 1998 2004
Entrez Id: 5819
Gene Symbol: NECTIN2
NECTIN2 		Q92692 nectin cell adhesion molecule 2 40 0.575 0.769 0.97 0.300 None 1.000 3 0 2018 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 110 0.358 0.885 2.9E-02 0.300 None 1.000 3 0 2005 2018
Entrez Id: 1191
Gene Symbol: CLU
CLU 		P10909 clusterin 66 0.426 0.885 7.8E-05 0.300 None 1.000 3 0 2009 2011
Entrez Id: 341
Gene Symbol: APOC1
APOC1 		P02654 apolipoprotein C1 13 0.581 0.577 0.22 0.300 None 1.000 2 0 2018 2018
Entrez Id: 4129
Gene Symbol: MAOB
MAOB 		P27338 monoamine oxidase B 35 0.533 0.808 1.00 0.300 None 1.000 2 0 1994 2011
Entrez Id: 406938
Gene Symbol: MIR146A
MIR146A 		microRNA 146a 21 0.398 0.885 0.300 None 1.000 2 0 2011 2015
Entrez Id: 1378
Gene Symbol: CR1
CR1 		P17927 complement C3b/C4b receptor 1 (Knops blood group) 12 0.533 0.808 1.6E-35 0.300 None 1.000 2 0 2009 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		P29474 nitric oxide synthase 3 138 0.378 0.885 6.7E-07 0.300 None 1.000 2 0 1999 2006
Entrez Id: 3630
Gene Symbol: INS
INS 		P01308 insulin 157 0.445 0.923 0.30 0.300 None 1.000 2 0 1998 2005