Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3 		0.310 GeneticVariation disease BEFREE A dual luciferase reporter assay was performed to determine whether the SNP rs10754558 might be responsible for the altered NLRP3 gene expression in AV by disrupting the interaction between micro-RNA (miR)-4273 and NLRP3 mRNA. 29888470 2019
Entrez Id: 54984
Gene Symbol: PINX1
PINX1 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 79783
Gene Symbol: SUGCT
SUGCT 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 79096
Gene Symbol: C11orf49
C11orf49 		0.100 GeneticVariation disease GWASCAT Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne. 24399259 2014
Entrez Id: 80326
Gene Symbol: WNT10A
WNT10A 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 643723
Gene Symbol: LYPLAL1-DT
LYPLAL1-DT 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 646023
Gene Symbol: ADORA2A-AS1
ADORA2A-AS1 		0.100 GeneticVariation disease GWASCAT Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. 24927181 2014
Entrez Id: 646023
Gene Symbol: ADORA2A-AS1
ADORA2A-AS1 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 1936
Gene Symbol: EEF1D
EEF1D 		0.100 GeneticVariation disease GWASCAT Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs. 29855537 2018
Entrez Id: 55732
Gene Symbol: C1orf112
C1orf112 		0.100 GeneticVariation disease GWASCAT Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne. 24399259 2014
Entrez Id: 10509
Gene Symbol: SEMA4B
SEMA4B 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 399909
Gene Symbol: PCNX3
PCNX3 		0.100 GeneticVariation disease GWASCAT Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. 30542056 2018
Entrez Id: 7324
Gene Symbol: UBE2E1
UBE2E1 		0.100 GeneticVariation disease GWASCAT Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. 24927181 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE This case-control study investigated the association of the TNF -308 G>A and -238 G>A SNPs with acne vulgaris in a high-risk Pakistani population. 26373312 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE Tumor necrosis factor-α -308 G/A and interleukin 10 -1082 A/G gene polymorphisms in patients with acne vulgaris. 22835835 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE Carriage of the GAG haplotype of TNF is linked with borderline susceptibility to acne vulgaris. 24334867 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE Genetic variants of the TNFα gene may affect the risk of acne vulgaris. 20386917 2011
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE This meta-analysis suggests that the -308 G/A polymorphism in the TNF gene contributes to acne vulgaris risk, especially in Caucasian populations. 24498378 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. 20861605 2010
Entrez Id: 3552
Gene Symbol: IL1A
IL1A 		0.050 GeneticVariation disease BEFREE This study aimed to investigate the association between IL-1A (-889) gene polymorphism and acne vulgaris in a sample of patients. 29498183 2019
Entrez Id: 7097
Gene Symbol: TLR2
TLR2 		0.040 GeneticVariation disease BEFREE The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne. 20861605 2010
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.030 GeneticVariation disease BEFREE There were no significant associations between the IL-6 572 variant genotypes and either patient sex or AV severity. 30652337 2019
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.030 GeneticVariation disease BEFREE Neither PPARγ Pro12Ala nor C161T polymorphism was associated with the risk of AV but the Pro allele was a risk factor for AV among all men and women patients ≥20years. 29120856 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.030 GeneticVariation disease BEFREE The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris. 24984871 2014
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.030 GeneticVariation disease BEFREE The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of acne vulgaris. 25432444 2015