|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) on RA identified known and novel susceptibility genes like HLA-DRB1, PTPN22, STAT4, TRAF1/C5, OLIG3/TNFAIP3, CD40, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, IL2RB, and KIF5A-PIP4K2C.
|
20398001 |
2010 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 alleles were determined in the 92 patients, in 29 DR4 positive rheumatoid arthritis (RA) patients, and in 148 controls from the same geographical area by polymerase chain reaction amplification and oligonucleotide hybridisation.
|
10225816 |
1999 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The current study was undertaken to assess the relationship between anti-CarP antibodies and HLA-DRB1 alleles in RA.
|
30277011 |
2019 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data emphasize the importance of defining haplotypes when trying to understand the HLA associations with disease, and they clearly demonstrate that such associations with RA are complex and cannot be completely explained by the DRB1 locus.
|
12181776 |
2002 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that two doses of predisposing DQ alleles strongly predisposed to RA, even in individuals with a single dose of SE while DRB1 alleles carrying the motif DERAA confered a dominant protection in DQ5-positive individuals.
|
10027783 |
1999 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, several other DRB1 alleles protect against RA.
|
28711139 |
2017 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two RA-associated haplotypes on the background of DRB1*0404 were identified in a 126-kb region surrounding and centromeric to the TNF locus.
|
15248209 |
2004 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotypes carrying the minor alleles and HLA-DRB1 shared epitope (SE) alleles (P = 9.4 x 10(-21)) were also associated with increased RA susceptibility.
|
16385500 |
2006 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether smoking and HLA-DRB1 shared-epitope (SE) alleles interact differently in the development of the two major subgroups of rheumatoid arthritis (RA), anti-citrullinated proteins antibody (ACPA)-positive and ACPA-negative disease, in a multiethnic population of Asian descent.
|
22537824 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations.
|
28271077 |
2017 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides an association with HLA-DRB1* shared epitope alleles other gene polymorphisms located inside and outside the HLA seem to influence the risk of cardiovascular disease in RA.
|
27490206 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1-DERAA alleles showed a protective effect against RA (OR 0.42; P < 0.001).
|
21952999 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, the combination of DRB1*03 and DRB1*13 was significantly associated with increased risk of developing ACPA-negative RA (RR 2.07 [95% CI 1.17-3.67]).
|
19333936 |
2009 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Certain HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) are associated with rheumatoid arthritis (RA).
|
24336335 |
2015 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).
|
26681695 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The largest genetic risk to develop rheumatoid arthritis (RA) arises from a group of alleles of the HLA DRB1 locus ('shared epitope', SE).
|
23121884 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens.
|
18954286 |
2009 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of HLA-DRB1 SE alleles and genotype with the development of bony erosions in RA by meta-analysis.
|
14872482 |
2004 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 haplotypes are independently and variably associated with seropositivity, autoantibody concentrations, and outcomes in RA.
|
30824656 |
2019 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Different HLA-DRB1 alleles are linked to RA susceptibility across different ethnicities.
|
27338350 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association with of HLA-DRB1*04 allele in our patients with RA was accounted for mainly by the seropositive group of patients (P < 0.05).
|
16226480 |
2006 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 allele distribution and its relation to rheumatoid arthritis in eastern Black Sea Turkish population.
|
21246357 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis.
|
26268815 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-linked genes, and in particular the HLA-DRB1 SE alleles, predispose much more strongly to ACPA-positive than to ACPA-negative RA.
|
21339219 |
2011 |