|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patient characteristics, clinical signs and symptoms, rheumatoid factor (RF) status, and HLA-DRB1 genotypes were available for 154 Caucasian women with RA.
|
16960929 |
2006 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By analyzing homozygote intensities, an ROH that is anchored by the single nucleotide polymorphism rs2027852 and flanked by HLA-DRB6 and HLA-DRB1 was found associated with increased risk for RA.
|
22536334 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The effect of human lymphocyte antigen-DRB1 shared epitope alleles on autoantibody positivity was limited to RA patients who were exposed to Aa These studies identify the periodontal pathogen Aa as a candidate bacterial trigger of autoimmunity in RA.
|
27974664 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G > A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A > C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA.
|
22927710 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, vaccinations did not increase the risk of RA in smokers or carriers of HLA-DRB1 shared epitope alleles, two groups with established risk factors for RA.
|
20603497 |
2010 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
First, we could demonstrate and further replicate an interaction between a protective haplotype in HTR2A and HLA-DRB1 SE alleles regarding risk of developing autoantibody-positive RA.
|
20179740 |
2010 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specificities differs from males to females: DR1 was increased among male patients, whereas DR4 as well as DR10 were preferentially associated with female RA.
|
10626740 |
1999 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The SNP analysis detected HLA*DRB1, the major RA susceptibility locus (P=.00004), with a linkage interval of 31 cM, compared with a 50-cM linkage interval detected by the microsatellite scan.
|
15154113 |
2004 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DRB1 rs660895 showed both wild (AA) and heterozygote (AG) genotype but the heterozygote allele was found to be associated with reduced risk of RA compared to controls [OR = 0.531, p = .024].
|
29168332 |
2018 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In individuals carrying two copies of the HLA-DRB1 SE, 55% of ACPA-positive RA was attributable to smoking.
|
21149499 |
2011 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0405 and DRB1*0802, which are both rare alleles in Caucasians, are positively and negatively correlated, respectively, with the pathogenesis of RA in Japan.
|
8697652 |
1996 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1*13 allele (the subtype allele of DR6, reported to be protective against the development of RA) was found in 14/119 (12%) of female but in none of the male patients (p=0.036).
|
11247876 |
2001 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A prediction score based on the hypermethylated FLS candidates had an area under the curve of 0.73 for association with RA case status, which compared favorably to the association of RA with the HLA-DRB1 shared epitope risk allele and with a validated RA genetic risk score.
|
27723282 |
2017 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results in this population indicate that shared epitopes in the third hypervariable region of DRB1 alleles also play a role in susceptibility to RA.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1895259 |
1991 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods.
|
7763111 |
1995 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In contrast, RA onset above 60 years is associated with HLA-DRB1*01.
|
12077707 |
2002 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patients with rheumatoid arthritis have a unique T-cell repertoire that not only reflects the influence of disease-associated HLA-DRB1 alleles but also is greatly skewed by the clonal expansion of few CD4+ and CD8+ T-cell specificities.
|
8619093 |
1995 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DRB1 alleles sharing SE are those conferring susceptibility to RA.
|
23958703 |
2013 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To examine whether polymyalgia rheumatica (PMR) and late onset rheumatoid arthritis have identical or similar HLA-DRB1 genetic associations.
|
11196513 |
2001 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Live birth deliveries were significantly protective for women with 0 but not for those with 1 or 2 copies of the RA risk-associated HLA-DRB1 shared epitope sequence for erosion score (RR 0.26 95% CI 0.09-0.89) and joint count (RR 0.28 95% CI 0.09-0.87).
|
31324468 |
2020 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several studies have shown that HLA-DRB1 alleles are associated with RA, whereas others have indicated that genes not linked to the HLA complex are also involved.
|
8323379 |
1993 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more than 10 regions outside the MHC.
|
19772830 |
2009 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, haplotype c1 (DQB1*0201-DRB1*0301-D6S1014*143-D6S273*139-D6STNFa*99-MIB*350-C1-2-5*196) was significantly associated with RA predisposition.
|
12455817 |
2002 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently we have discovered that shared epitope (SE)-positive HLA-DRB1 alleles are exclusively associated with a subgroup of RA patients that test positive for auto-antibodies against cyclic citrullinated peptides.
|
16728269 |
2006 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In Japanese patients with RA, HLA-DRB1 SE alleles are associated with production of anti-CCP antibodies and HLA-DRB1 alleles appear to be differently associated with early RA depending on anti-CCP positivity as in Caucasian patients with RA.
|
17543145 |
2007 |