|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2).
|
26681695 |
2016 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 genes and extraarticular rheumatoid arthritis.
|
16542468 |
2006 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The largest genetic risk to develop rheumatoid arthritis (RA) arises from a group of alleles of the HLA DRB1 locus ('shared epitope', SE).
|
23121884 |
2012 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, DRB1*1405 was suggested to possess a protective role for the development of RA in DRB1*0405-positive individuals.
|
10765919 |
2000 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens.
|
18954286 |
2009 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of HLA-DRB1 SE alleles and genotype with the development of bony erosions in RA by meta-analysis.
|
14872482 |
2004 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Naturally processed peptides from immunoaffinity-purified HLA-DRB1*0401, -DRB1*0404 (rheumatoid arthritis (RA)-associated), and -DRB1*0402 (non-RA-associated) molecules were analyzed by capillary liquid chromatography and mass spectrometry.
|
7499850 |
1995 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 haplotypes are independently and variably associated with seropositivity, autoantibody concentrations, and outcomes in RA.
|
30824656 |
2019 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis.
|
22937072 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Different HLA-DRB1 alleles are linked to RA susceptibility across different ethnicities.
|
27338350 |
2016 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues.
|
25524867 |
2014 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
In cohort 2, HLA-DMA*0103 was associated with severe RA in patients negative for HLA-DRB1*04 (OD = 5.4; p = 0.014).
|
15547082 |
2004 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The association with of HLA-DRB1*04 allele in our patients with RA was accounted for mainly by the seropositive group of patients (P < 0.05).
|
16226480 |
2006 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that the associations between HLA-DRB1 and DQA1 loci and cardiovascular disease exists but that they are considerably weaker than those previously reported for other diseases with an established autoimmune aetiology such as type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis.
|
20141563 |
2010 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1 allele distribution and its relation to rheumatoid arthritis in eastern Black Sea Turkish population.
|
21246357 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DRB1 alleles with clinical responses to the anti-interleukin-17A monoclonal antibody secukinumab in active rheumatoid arthritis.
|
26268815 |
2016 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1 allelic groups were genotyped in 1,073 ACPA-positive RA patients from the Swedish Epidemiological Investigation of Rheumatoid Arthritis study.
|
22307773 |
2012 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Memory CXCR4(+)CD4(+) T cells may serve as a powerful biomarker for unraveling the linkage between HLA-DRB1 genotype and disease activity in RA.
|
27385284 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-linked genes, and in particular the HLA-DRB1 SE alleles, predispose much more strongly to ACPA-positive than to ACPA-negative RA.
|
21339219 |
2011 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patient characteristics, clinical signs and symptoms, rheumatoid factor (RF) status, and HLA-DRB1 genotypes were available for 154 Caucasian women with RA.
|
16960929 |
2006 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By analyzing homozygote intensities, an ROH that is anchored by the single nucleotide polymorphism rs2027852 and flanked by HLA-DRB6 and HLA-DRB1 was found associated with increased risk for RA.
|
22536334 |
2012 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The effect of human lymphocyte antigen-DRB1 shared epitope alleles on autoantibody positivity was limited to RA patients who were exposed to Aa These studies identify the periodontal pathogen Aa as a candidate bacterial trigger of autoimmunity in RA.
|
27974664 |
2016 |
|
HLA-DRB1
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this regard, besides a strong association between the HLA-DRB1∗04 shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G > A, rs1800629) of the TNFA locus, the rs1801131 polymorphism (A > C; position + 1298) of the MTHFR locus, or a deletion of 32 base pairs on the CCR5 gene, seem to be associated with the risk of CV disease in patients with RA.
|
22927710 |
2012 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis.
|
19151010 |
2010 |
|
HLA-DRB1
|
0.500 |
Biomarker
|
disease |
BEFREE |
Consistent with the findings in European and East Asian populations, the association of RA with HLA-DRB1 amino acid position 11 conferred the strongest effect (P = 4.8 × 10<sup>-16</sup> ), and a weighted genetic risk score of previously associated RA loci was found to be associated with RA (P = 3.41 × 10<sup>-5</sup> ) and with seropositive RA (P = 1.48 × 10<sup>-6</sup> ) in this population.
|
28118524 |
2017 |